Results 61 to 70 of about 1,628,800 (244)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Nail trick

, 2011
This activity proposes to balance 15 nails on the head of one nail. Nails can be balanced across the first nail if their weight is evenly distributed and if they can be stopped from slipping off.
Science Museum
core   +1 more source

Nail psoriasis: a review of the literature [PDF]

Anais Brasileiros de Dermatologia, 2014
Nails are considered epidermal appendages, and as such, are commonly affected in patients with psoriasis, 80% of whom are likely to develop nail psoriasis as a result of their condition.
Karen Regina Rosso Schons, Cristiane Faccin Knob, Nádia Murussi, André Avelino Costa Beber, Walter Neumaier, Odirlei André Monticielo   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Leprosy with dystrophy in twenty nails: Detection of acid-fast bacilli in nail biopsy

Journal of Infection and Public Health
Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae (M. leprae) and/or M. lepromatosis that has a wide spectrum of clinical presentations and multi-organ involvement, primarily on the skin and peripheral nerves.
Hendra Gunawan, Risa Miliawati Nurul Hidayah, Kartika Ruchiatan, Yogi Faldian, Hermin Aminah Usman, Dwi Bandang Saskia   +5 more
doaj   +1 more source

A tumor hidden beneath the nail plate: Report of a rare case of onychomatricoma with three-dimensional histopathological analysis and immunohistochemical study

Indian Journal of Dermatology, 2015
Onychomatricoma is a tumor of the nail matrix which often presents with alterations in the nail plate while the tumor itself is concealed beneath the nail plate.
Shital Amin Poojary, Vikas Halwai
doaj   +1 more source

Targeting nail psoriasis: IL-17A inhibitors demonstrate site-specific superiority over IL-23 inhibitor in a 24-week dermoscopy-guided real-world cohort

Frontiers in Immunology
ObjectiveTo compare the real-world clinical efficacy and safety of interleukin (IL)-17A inhibitors (secukinumab [SEC] and ixekizumab [IXE]) versus the IL-23 inhibitor guselkumab (GUS) in patients with nail psoriasis, with a focus on site-specific ...
Xiamei Yan, Xiamei Yan, Minglan Shi, Bin Wang, Lihua Zeng, Huiwei Wang, Jialiang Shi, Yaqian Cui, Suchun Hou   +8 more
doaj   +1 more source

Characterization of cultured nail matrix cells

, 1994
Background: Cultures of epidermal cells are commonly used to study skin biology and differentiation. Recently a method to culture nail matrix cells has been established.
Torrisi, Maria Rosaria, Faggioni, Alberto, Cameli, Norma, Picardo, Mauro, Marchese, Cinzia, Zompetta, Claudia, Tosti, Antonella   +6 more
core   +1 more source

Nail consistency

, 2005
The changes in brittle, friable nails are often confined to the surface of the nail plate; this occurs in superficial white onychomycosis and may be seen after the application of nail polish or base coat which causes ‘granulations’ in the nail keratin ...

core   +2 more sources