Results 71 to 80 of about 1,628,800 (244)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
, 2016 This activity proposes to balance 15 nails on the head of one nail. Nails can be balanced across the first nail if their weight is evenly distributed and if they can be stopped from slipping off.
Science Museum
core +1 more source
Nail colour changes (chromonychia)
, 2005 There are some important points to note concerning the examination of abnormal nails for colour changes. The nails should be studied with the fingers completely relaxed and not pressed against any surface.
core +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
When all you have is a dermatoscope—start looking at the nails
Dermatology Practical & Conceptual, 2014 Pigmented and non-pigmented nail alterations are a frequent challenge for dermatologists. A profound knowledge of clinical and dermatoscopic features of nail disorders is crucial because a range of differential diagnoses and even potentially life ...
Holger A. Haenssle +7 more
doaj +1 more source
Expression of integrins in human nail matrix
, 1994 The aim of this study was to characterize cell-cell and cell-matrix interaction by evaluating the expression of different integrins in the nail matrix.
Picardo, M +5 more
core +1 more source
Is there a bone-nail specific entry point? automated fit quantification of tibial nail designs during the insertion for six different nail entry points [PDF]
, 2015 Intramedullary nailing is the standard fixation method for displaced diaphyseal fractures of tibia. Selection of the correct nail insertion point is important for axial alignment of bone fragments and to avoid iatrogenic fractures.
Schuetz, Michael +7 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Afectación ungueal de origen ocupacional Nail involvement of occupational origin
Medicina y Seguridad del Trabajo, 2012 Desde el siglo V a.C. Hipócrates ya describía las afectaciones ungueales, las cuales luego se relacionaban con enfermedades sistémicas o adquiridas.
Carmen Karina Guzmán Vera +3 more
doaj
Unveiling Giant Onychomatricoma: A Diagnostic and Therapeutic Challenge
Case Reports in Dermatological MedicineOnychomatricoma is a rare benign tumor of the nail matrix that is often misdiagnosed due to its resemblance to other nail conditions, particularly onychomycosis.
Katherine Nicole Calderón Tiburcio +3 more
doaj +1 more source