Results 71 to 80 of about 1,016 (126)

Pentazocine, cyclazocine, and nalorphine as discriminative stimuli

Psychopharmacology, 1977
Pentazocine, cyclazocine, and nalorphine are narcotic antagonists that also have analgesic activity of their own. The present investigation compared the stimulus properties of these three drugs in rats. Each drug was used as a discriminative stimulus for a separate group of rats.
exaly   +3 more sources

NALORPHINE

Lancet, The, 1963
exaly   +2 more sources

The interaction of morphine and nalorphine on respiration

Clinical Pharmacology & Therapeutics, 1968
A study was carried out in volunteers to determine the relative potency as respiratory depressants of nalorphine and morphine and their interaction when administered together. The relative potency of nalorphine when compared to morphine was found to be 0.74 (13.5 mg. nalorphine ≎ 10 mg. morphine).
J W, Bellville, G, Fleischli
openaire   +2 more sources

Morphine and Nalorphine impair Neuromuscular Transmission

Nature New Biology, 1971
THE narcotic analgesic morphine and the analgesic-antagonist nalorphine both depress the twitch and tetanus of the coaxially stimulated guinea-pig ileum1. There is general agreement that morphine impairs the release of acetylcholine at this peripheral muscarinic site1–4. Less is agreed about the effects of morphine at nicotinic sites1,5–7.
C, Pinsky, R C, Frederickson
openaire   +2 more sources

NALORPHINE (N-ALLYLNORMORPHINE)

A.M.A. Archives of Internal Medicine, 1954
HISTORY THE HISTORY of N-substituted allyl compounds of the morphine series is both fascinating and instructive. Pohl, 1 almost 40 years ago, became interested in the work of a colleague named Piazza. The latter worker had found allyl compounds to be, in general, irritating to tissues and (under some circumstances) productive of stimulant effects on ...
openaire   +2 more sources

Pharmacological effects of nalorphine and nalorphine-7,8-oxide (nalorphine-epoxide): interaction of the intrinsic activity, affinity and pharmacological responses.

Archives internationales de pharmacodynamie et de therapie, 1986
We examined the relationship between the pharmacological effects and the interactions of the receptors of nalorphine and its epoxide. The abilities of nalorphine-epoxide to displace [3H]-dihydromorphine (mu-site) and [3H]-ethylketocyclazocine (kappa-site) were practically equal to those of the parent compound, nalorphine, using binding assay to the rat
F, Konno, C, Kobayashi, R, Morimoto, I, Takayanagi, N, Cho, M, Hirobe   +5 more
openaire   +1 more source

NALORPHINE HYDROCHLORIDE, N.N.R. ("NALLINE HYDROCHLORIDE")

Annals of Internal Medicine, 1954
Excerpt Although morphine has been one of the most important drugs in the physician's armamentarium for many years, its serious disadvantages have always been recognized.
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Antagonism of some toxic effects of dextropropoxyphene by nalorphine

Toxicology and Applied Pharmacology, 1962
Abstract It has been shown that nalorphine changes the LD 50 of the intraperitoneally administered dextropropoxyphene from 68 mg/kg to 105 mg/kg. Furthermore, nalorphine antagonizes the convulsant effect of dextropropoxyphene. Also, the dextropropoxyphene-induced convulsions were of cerebral origin as evidenced by the abolition of these convulsions ...
J E, CHAPMAN, E J, WALASZEK
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Sigma effects of nalorphine in the chronic spinal dog

Drug and Alcohol Dependence, 1976
The effects of graded doses of nalorphine and morphine were studied in nondependent chronic spinal dogs. Morphine and low doses of nalorphine produced behavioral changes characterized by indifference, whereas the largest dose of nalorphine produced canine delirium indistinguishable from that produced by SKF-10, 047 or cyclazocine.
P E, Gilbert, W R, Martin
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A study of the interaction of nalorphine with fentanyl and innovar®

Toxicology and Applied Pharmacology, 1964
Abstract The lower segment of the biphasic mortality dose response curve of fentanyl citrate appears to be due to respiratory depression and is readily antagonized by nalorphine. The analgesic activity of fentanyl citrate and of Innovar ® is also antagonized by nalorphine, as is the case with morphine.
J E, GARDOCKI, J, YELNOSKY, W F, KUEHN, J C, GUNSTER   +3 more
openaire   +2 more sources