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Annals of Emergency Medicine, 1983
Naloxone hydrochloride, a synthetic N-allyl derivative of oxymorphone, is an effective agent for the reversal of the cardiovascular and respiratory depression associated with narcotic and possibly some non-narcotic overdoses. It is essentially a pure narcotic antagonist, is relatively safe, and is a useful diagnostic and therapeutic agent.
K A, Handal +2 more
openaire +2 more sources
Naloxone hydrochloride, a synthetic N-allyl derivative of oxymorphone, is an effective agent for the reversal of the cardiovascular and respiratory depression associated with narcotic and possibly some non-narcotic overdoses. It is essentially a pure narcotic antagonist, is relatively safe, and is a useful diagnostic and therapeutic agent.
K A, Handal +2 more
openaire +2 more sources
Cochrane Database of Systematic Reviews, 2003
There is pre-clinical evidence, involving several animal species, suggesting that opioid peptides play a role in the physiopathology of shock (endotoxic, hypovolemic, cardiogenic, spinal, anaphylactic). Many case reports have suggested that naloxone (an opiate antagonist) might be an effective treatment for shock in humans, but others have not ...
B, Boeuf +6 more
openaire +2 more sources
There is pre-clinical evidence, involving several animal species, suggesting that opioid peptides play a role in the physiopathology of shock (endotoxic, hypovolemic, cardiogenic, spinal, anaphylactic). Many case reports have suggested that naloxone (an opiate antagonist) might be an effective treatment for shock in humans, but others have not ...
B, Boeuf +6 more
openaire +2 more sources
Naloxone and Alcoholic Intoxication
Annals of Internal Medicine, 1982Excerpt To the editor: In a recent article, Lyon and Antony (1) reported the dramatic effect of naloxone hydrochloride in two comatose patients with alcoholic intoxication.
Lignian, Hervé +2 more
openaire +3 more sources
Naloxone without the needle − systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal [PDF]
Introduction Deaths from opioid overdose can be prevented through administration of the antagonist naloxone, which has been licensed for injection since the 1970s.
John Strang +2 more
exaly +2 more sources
Absorption of naloxone in patients prescribed buprenorphine‐naloxone
The American Journal on AddictionsAbstractBackground and ObjectivesWhen administered as prescribed, the naloxone component of buprenorphine‐naloxone combination medications is putatively considered inert due to reduced naloxone bioavailability via transmucosal. However, there is a growing body of evidence to the contrary.
Ian Michel +5 more
openaire +2 more sources
Science Signaling
A negative allosteric modulator of the μ-opioid receptor enhances the efficacy of naloxone.
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A negative allosteric modulator of the μ-opioid receptor enhances the efficacy of naloxone.
openaire +2 more sources

