Results 231 to 240 of about 80,877 (282)

The Effects of Naloxone Access Laws on Opioid Abuse, Mortality, and Crime

Journal law and economy, 2022
The United States is experiencing an epidemic of opioid abuse. In response, states have implemented policies including increased access to naloxone, a drug that can save lives when administered during an overdose.
Jennifer L. Doleac, Anit Mukherjee
semanticscholar   +1 more source

Evaluating equity in community-based naloxone access among racial/ethnic groups in Massachusetts

Drug and Alcohol Dependence, 2022
Background: Racial/ethnic minorities have experienced disproportionate opioid-related overdose death rates in recent years. In this context, we examined inequities in community-based naloxone access across racial/ethnic groups in Massachusetts.
Shayla Nolen, Xiao Zang, Avik Chatterjee, Czarina N. Behrends, Traci C. Green, B. Linas, J. Morgan, Sean M. Murphy, A. Walley, B. Schackman, Brandon D. L. Marshall   +10 more
semanticscholar   +1 more source

Intranasal delivery of Naloxone-loaded solid lipid nanoparticles as a promising simple and non-invasive approach for the management of opioid overdose.

International journal of pharmaceutics, 2021
Naloxone is an opioid receptor antagonist that can eradicate all pre-indications of the toxicity and inverse the opioid overdose. However, oral administration of naloxone offers limitations such as its extensive first-pass metabolism that results in poor
Nazeer Hasan, M. Imran, Prashant Kesharwani, Kushagra Khanna, R. Karwasra, N. Sharma, Sonalika Rawat, Deeksha Sharma, F. Ahmad, G. Jain, A. Bhatnagar, S. Talegaonkar   +11 more
semanticscholar   +1 more source

Naloxone

Annals of Emergency Medicine, 1983
Naloxone hydrochloride, a synthetic N-allyl derivative of oxymorphone, is an effective agent for the reversal of the cardiovascular and respiratory depression associated with narcotic and possibly some non-narcotic overdoses. It is essentially a pure narcotic antagonist, is relatively safe, and is a useful diagnostic and therapeutic agent.
K A, Handal, J L, Schauben, F R, Salamone   +2 more
openaire   +2 more sources

Microinduction of Buprenorphine/Naloxone: A Review of the Literature.

American Journal on Addictions, 2020
BACKGROUND AND OBJECTIVES Buprenorphine's high-binding affinity as a partial µ-opioid agonist displaces preexisting full agonists causing precipitated withdrawal, which requires most individuals starting buprenorphine to endure moderate withdrawal prior ...
Saeed Ahmed, Siddhi Bhivandkar, Brady B. Lonergan, J. Suzuki   +3 more
semanticscholar   +1 more source

Naloxone for shock

Cochrane Database of Systematic Reviews, 2003
There is pre-clinical evidence, involving several animal species, suggesting that opioid peptides play a role in the physiopathology of shock (endotoxic, hypovolemic, cardiogenic, spinal, anaphylactic). Many case reports have suggested that naloxone (an opiate antagonist) might be an effective treatment for shock in humans, but others have not ...
B, Boeuf, V, Poirier, F, Gauvin, A M, Guerguerian, C, Roy, C A, Farrell, J, Lacroix   +6 more
openaire   +2 more sources

Naloxone and Alcoholic Intoxication

Annals of Internal Medicine, 1982
Excerpt To the editor: In a recent article, Lyon and Antony (1) reported the dramatic effect of naloxone hydrochloride in two comatose patients with alcoholic intoxication.
Lignian, Hervé, Fontaine, Jeanine, Askenasi, Robert   +2 more
openaire   +3 more sources

Cost-effectiveness analysis of alternative naloxone distribution strategies: First responder and lay distribution in the United States.

The International journal on drug policy, 2020
BACKGROUND The U.S. is facing an unprecedented number of opioid-related overdose deaths, and an array of other countries have experienced increases in opioid-related fatalities.
T. Townsend, F. Blostein, T. Doan, Samantha Madson-Olson, P. Galecki, D. Hutton   +5 more
semanticscholar   +1 more source

Naloxone without the needle − systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal [PDF]

Drug and Alcohol Dependence, 2016
Introduction Deaths from opioid overdose can be prevented through administration of the antagonist naloxone, which has been licensed for injection since the 1970s.
Ben Forbes, David Taylor, John Strang
exaly   +3 more sources

Absorption of naloxone in patients prescribed buprenorphine‐naloxone

The American Journal on Addictions
AbstractBackground and ObjectivesWhen administered as prescribed, the naloxone component of buprenorphine‐naloxone combination medications is putatively considered inert due to reduced naloxone bioavailability via transmucosal. However, there is a growing body of evidence to the contrary.
Ian Michel, Domenic Ochal, Aniket Paharia, Paul Jannetto, Scott Breitinger, Tyler Oesterle   +5 more
openaire   +2 more sources