Results 71 to 80 of about 3,607 (224)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dance of the Sticks at the Klukwan Potlatch, Klukwan, Alaska, October 12, 1898 [PDF]

open access: yes, 1898
Performing inside the Frog House of the Gaanaaxteidi clan of the Chilkat Tlingit. This image is of the old Frog house, built in the traditional form of architecture. Pillsbury 425 Copy also made by E.A. Hegg (601).
Pillsbury, Arthur C. (Arthur Clarence)
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Christening of the seaplane "Tilikum" during the Golden Potlatch, Seattle, July 1914 [PDF]

open access: yes, 1914
The Tilikums of Elttaes were a fraternal, civic organization composed primarily of influential white Seattle area businessmen, who used Native American imagery to promote tourism and the economic development of the city.
Nowell, Frank H.
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Seaplane on Lake Union during Golden Potlatch, Seattle, July 1914 [PDF]

open access: yes, 1914
The Tilikums of Elttaes were a fraternal, civic organization composed primarily of influential white Seattle area businessmen, who used Native American imagery to promote tourism and the economic development of the city.
Nowell, Frank H.
core  

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Seaplane flying over water with spectators on shore, Golden Potlatch, Seattle, ca. 1913 [PDF]

open access: yes, 1913
The Tilikums of Elttaes were a fraternal, civic organization composed primarily of influential white Seattle area businessmen, who used Native American imagery to promote tourism and the economic development of the city.
Nowell, Frank H.
core  

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