Results 91 to 100 of about 2,019,805 (313)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Street-Name Patterns in Denver

open access: yesNames, 1954
-IN THE LATEAUTUMNOF 1858 some of the Pikes Peak gold prospectors decided to winter at the foot of the Rocky Mountains. Although they were merely squatters on Indian territory they staked out a tract of land at the junction of Cherry Creek and the South Platte River, and on November 6 proceeded to map in gridiron form, the first streets of what later ...
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Role of the lateral prefrontal cortex in speech monitoring

open access: yesFrontiers in Human Neuroscience, 2013
The role of lateral prefrontal cortex in speech monitoring has not been delineated. Recent work suggests that medial frontal cortex (MFC) is involved in overt speech monitoring initiated before auditory feedback.
Stephanie K. Riès   +6 more
doaj   +1 more source

Naming a Structured World: A Cultural Route to Duality of Patterning

open access: yesPLoS ONE, 2012
The lexicons of human languages organize their units at two distinct levels. At a first combinatorial level, meaningless forms (typically referred to as phonemes) are combined into meaningful units (typically referred to as morphemes). Thanks to this, many morphemes can be obtained by relatively simple combinations of a small number of phonemes.
TRIA, FRANCESCA   +2 more
openaire   +5 more sources

Carefree Pattern

open access: yes, 1975
McCall's Carefree Pattern #4387 by Halston to make stretch knit cape with asymmetrical drape and flared skirt with waistband, including illustrations of the finished pieces and information about sizing and construction on the ...
Halston, 1932-1990   +1 more
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Carefree Pattern

open access: yes, 1973
McCall's Carefree Pattern #3818 by Halston to make a jacket with short notched lapels, shirt with convertible collar and center front button closure, and flared pants, including illustrations of the finished pieces and information about sizing and ...
Halston, 1932-1990   +1 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

A Cognitive Onomastics Study of Traditional Chinese Herb Names

open access: yesSAGE Open
Herb names not only facilitate identification but also convey crucial information regarding the potential uses and benefits of traditional Chinese herbs.
Xiangyong Jiang, Haini Deng
doaj   +1 more source

Home - About - Disclaimer - Privacy