Results 81 to 90 of about 2,019,805 (313)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Naming and Branding of Madurese Traditional Culinary
Mozaik HumanioraMadura has diverse culinary specialties. This aspect of culinary naming and branding is interesting to study in relation to culinary tourism. This study aims to explain aspects of food naming and their patterns in traditional Sumenep culinary delights ...
Rosyida Ekawati +1 more
doaj +1 more source
Naming New Stimuli After Selection by Exclusion
Paidéia (Ribeirão Preto), 2013 Responding by exclusion in matching-to-sample tasks is a robust behavioral pattern in humans. A single selection, however, does not ensure learning of the arbitrary relationship between the sample and the selected comparison stimulus.
Aline Roberta Aceituno da Costa +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 1999 Naming is a key issue in any distributed system. In particular, with the Open Hypermedia Systems Working Group's efforts towards openness and interoperability in Open Hypermedia Systems (OHS) resulting in the need for (globally) valid names for all types
Davis, Hugh C. +2 more
core +1 more source
, 1934 Envelope for a McCall Kaumagraph Transfer pattern to make appliqué tulip flower and flower pot designs for suggested items such as kitchen curtains, table runners and pot holders; includes illustrations of finished pieces and instructions for ...
McCall Pattern Company
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Frontiers in Neuroscience, 2017 Objective: Logopenic variant primary progressive aphasia (lvPPA) is commonly associated with Alzheimer's disease (AD) pathology. But lvPPA patients display different cognitive and anatomical profile from the common clinical AD patients, whose verbal ...
Khaing T. Win +11 more
doaj +1 more source
Naming: Design Pattern and Framework
, 1998 Naming is an important, but frequently overlooked, aspect of software systems. Usually, naming appears combined with other issues, e.g. distributed communication technology. This paper treats naming in isolation. It presents a naming design pattern which
António Rito Silva +2 more
core