Results 81 to 90 of about 7,734 (200)

New approach methodologies for evaluating developmental and reproductive toxicity potential: Review on state of the art, applicability for cosmetic related ingredients and coverage of developmental stages

NAM Journal
The development of in vitro developmental and reproductive toxicity (DART) models is challenging. We made a brief review of in silico models and an in-depth review of 17 established in vitro New Approach Methodologies (NAMs) used to assess the DART ...
M. Burbank, N.J. Hewitt, F. Gautier, A. Noel-Voisin, N. Golbamaki, R. Grall, M. Léonard, L. Carron, A. Riu, S. Emery, A. Detroyer, T. Bringel, L. Guillet-Revol, N. de Crozé, G. Ouédraogo   +14 more
doaj   +1 more source

Wave propagation in a nonlinear acoustic metamaterial beam considering third harmonic generation

New Journal of Physics, 2018
Nonlinear acoustic metamaterials (NAMs) provide new ways to control elastic waves. In this work, flexural wave propagation in an infinite NAM beam consisting of periodic Duffing resonators is reported by considering the third harmonic generation ...
Xin Fang, Jihong Wen, Dianlong Yu, Guoliang Huang, Jianfei Yin   +4 more
doaj   +1 more source

Liposomes as delivery vectors for nucleic acid mimics into Escherichia coli: effect of composition and functionalization

Frontiers in Bioengineering and Biotechnology
The growing threat of antimicrobial resistance (AMR) requires the development of novel therapeutic solutions and Nucleic Acid Mimics (NAMs) arepresent a promising alternative.
João P. Santos, Eva Pinho, Rita S. Santos, Joana A. Loureiro, Joana A. Loureiro, Maria C. Pereira, Rui M. Ferreira, Céu Figueiredo, Céu Figueiredo, Emílio Gomes, Emílio Gomes, Joana Castro, Daniela Araújo, Nuno M. Guimarães, Nuno F. Azevedo   +14 more
doaj   +1 more source

Empirical PK/PD Model for Differentiating Intrinsic Dosing Rules by Therapeutic Indication With Relevance for HIV‐1 Latency Reversal

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1414-1426, November 2026.
Romidepsin (RMD), an FDA‐approved histone deacetylase inhibitor for treating cancer, demonstrates potent latency‐reversing activity in vitro but has yielded suboptimal outcomes in kick‐and‐kill HIV‐cure trials when administered as a 5 mg/m2 infusion.
Lauren A. R. Tompkins, Amanda Poliseno, Airlie Ward, Edward P. Browne, Cassandra Gilbert, Craig Sykes, Angela D. M. Kashuba, Mackenzie L. Cottrell   +7 more
wiley   +1 more source

Lung microphysiological system for predicting antiviral drug efficacy for COVID-19

The Microbe
Development of physiologically relevant in vitro models that recapitulate key aspects of SARS-CoV-2 infections has proven challenging due to limitations associated with current New Approach Methodologies (NAMS).
F. Mba Medie, H. Kim, C.R. Fisher, N.J. Haroutunian, J.T. Borenstein   +4 more
doaj   +1 more source

Target‐Engagement Prediction From Molecular Structure, In Vitro and Animal Data: A Tutorial for Early Assessment of Clinical Drug Exposure and Therapeutic/Adverse Potential Using the ANDROMEDA and PLATO Software on the InSilicoTrials Platform

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 11, November 2026.
ABSTRACT The target‐engagement predictor, implemented within the InSilicoTrials cloud‐based, AI‐powered platform for model‐informed drug discovery and development, enables early exploration of time‐dependent pharmacological responses. Predictions can be generated using inputs ranging from molecular structure to in vitro, animal, and clinical data ...
Niccolò Totis, Fianne Sips, Simona Catozzi, Marc‐Antonio Bisotti, Pauline Bambury, Sofia Stathopoulos, Vincenzo Carbone, Luca Emili, Mario Torchia, Valentina Belgiovine, Fulvio Ciriaco, Orazio Nicolotti, Urban Fagerholm, Candice N. Baker, J. Matthew Mahoney, Daniel Röshammar, on behalf of the CARDIOVERSE Project   +16 more
wiley   +1 more source

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Frontiers in Toxicology
In the European regulatory context, rodent in vivo studies are the predominant source of neurotoxicity information. Although they form a cornerstone of neurotoxicological assessments, they are costly and the topic of ethical debate.
Tamara Tal, Tamara Tal, Oddvar Myhre, Ellen Fritsche, Ellen Fritsche, Ellen Fritsche, Joëlle Rüegg, Kai Craenen, Kiara Aiello-Holden, Caroline Agrillo, Patrick J. Babin, Beate I. Escher, Hubert Dirven, Kati Hellsten, Kristine Dolva, Ellen Hessel, Harm J. Heusinkveld, Yavor Hadzhiev, Selma Hurem, Karolina Jagiello, Beata Judzinska, Nils Klüver, Anja Knoll-Gellida, Britta A. Kühne, Marcel Leist, Malene Lislien, Jan L. Lyche, Ferenc Müller, John K. Colbourne, Winfried Neuhaus, Winfried Neuhaus, Giorgia Pallocca, Bettina Seeger, Ilka Scharkin, Stefan Scholz, Ola Spjuth, Monica Torres-Ruiz, Kristina Bartmann, Kristina Bartmann   +38 more
doaj   +1 more source

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, Volume 183, Issue 21, Page 6481-6500, November 2026.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

In Situ Observation of Pressure‐Enhanced Hydrous–Anhydrous Solid Solution in Lower‐Mantle SiO2–AlOOH Phases

Geophysical Research Letters, Volume 53, Issue 19, 16 October 2026.
Abstract Water plays a critical role in Earth's mantle dynamics and evolution, yet lower‐mantle storage mechanisms remain debated. δ‐AlOOH and SiO2 phases have been independently proposed as high‐pressure water hosts. Here, we conducted in situ synchrotron X‐ray diffraction experiments with a multi‐anvil apparatus and sintered diamond anvils to ...
M. Nishi, K. Takahashi, H. Dekura, K. Kawano, H. Koike, K. Nakamura, T. Kondo, H. Kuwahara, S. Kakizawa, N. Tsujino, Y. Higo   +10 more
wiley   +1 more source

Evolutionäre, funktionelle und mechanistische Charakterisierung mikrobieller Terpensynthase‐ähnlicher Gene aus Springschwänzen

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Eine Genomanalyse zeigte das Vorkommen zahlreicher Terpensynthasen des bakteriellen Typs in Springschwänzen. Vier Enzyme aus Sinella curviseta wurden funktionell charakterisiert, was zur Isolierung mehrerer Verbindungen führte, darunter Sinellenether, der erste identifizierte Diterpenether einer Terpensynthase mit einem neuartigen Grundgerüst.
Min Wang, Clement Schneider, Zarley Rebholz, Stefan Schulz, Kathy Darragh, Jeroen S. Dickschat   +5 more
wiley   +1 more source