Results 51 to 60 of about 7,458 (236)

Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice. [PDF]

, 2019
Approximately 15-40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are widely successful, yet have limited efficacy against CNS ...
Chen, Irvin SY, Guan, Xin, Kamata, Masakazu, Kranz, Emiko, Lee, YooJin, Liu, Chaoyong, Liu, Yang, Lu, Yunfeng, Martinez-Maza, Otoniel, Qin, Meng, Sun, Guibo, Sun, Xiaobo, Vinters, Harry V, Wang, Lan, Wen, Jing, Widney, Daniel, Wu, Di, Xu, Duo   +17 more
core  

Vesicular (liposomal and nanoparticulated) delivery of curcumin: a comparative study on carbon tetrachloride–mediated oxidative hepatocellular damage in rat model [PDF]

, 2016
The liver plays a vital role in biotransforming and extricating xenobiotics and is thus prone to their toxicities. Short-term administration of carbon tetrachloride (CCl4) causes hepatic inflammation by enhancing cellular reactive oxygen species (ROS ...
Ali, Nahid, Chakraborty, Somsuta, Das, Nirmalendu, Ghosh, Debasree, Ghosh, Swarupa, ThakurChoudhury, Somsubhra   +5 more
core   +1 more source

Effective Penetration of the Oxidized Keratin‐Rebonding Materials Into Hair Shafts Based on Charge Conversion

Advanced Healthcare Materials, EarlyView.
We have developed a smart hair‐repair ingredient based on β‐carboxylic acid amide that undergoes negative‐to‐positive charge conversion under mildly acidic conditions. The initial negative charge facilitates deep penetration into the hair fiber, while the subsequent positive charge enables re‐bonding with sulfonate groups in damaged hair keratin.
Sunyoung Kang, Serena Serin Park, Sugyeong Jeong, Seoyeon Kyung, Minjae Kim, Seok Kyun Yun, Hyun‐Na Kim, Seunghyun Kang, Yan Lee   +8 more
wiley   +1 more source

Terminology of polymers and polymerization processes in dispersed systems (IUPAC Recommendations 2011) [PDF]

, 2011
A large group of industrially important polymerization processes is carried out in dispersed systems. These processes differ with respect to their physical nature, mechanism of particle formation, particle morphology, size, charge, types of interparticle
Ingrid Meisel, IUPAC, José V. Alemán, Kazuyuki Horie, Michael Hess, Przemyslaw Kubisa, Richard G. Jones, Robert F. T. Stepto, Robert G. Gilbert, Sing, Smoluchowski, Stanislaw Slomkowski, Stanisław Penczek, Werner Mormann   +13 more
core   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

Effect of scaffold architecture and BMP-2/BMP-7 delivery on in vitro bone regeneration [PDF]

, 2010
The aim of this study was to develop 3-D tissue engineered constructs that mimic the in vivo conditions through a self-contained growth factor delivery system. A set of nanoparticles providing the release of BMP-2 initially followed by the release of BMP-
Hasirci, N., Hasirci, Vasif, Reis, R. L., Sousa, R. A., Yilgor, Pinar   +4 more
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Design, Formulation and in vivo Evaluation of Novel Honokiol-Loaded PEGylated PLGA Nanocapsules for Treatment of Breast Cancer

International Journal of Nanomedicine, 2020
Yusuf A Haggag,1 Rowida R Ibrahim,2 Amin A Hafiz3 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Tanta, Egypt; 2Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Tanta University, Tanta, Egypt ...
Haggag YA, Ibrahim RR, Hafiz AA
doaj  

Biodegradable Drug-Delivery Peptide Nanocapsules [PDF]

ACS Omega, 2019
Branched amphiphilic peptide capsules (BAPCs) are an efficient transport system that can deliver nucleic acids, small proteins, and solutes. The ability of BAPCs to break down is essential to their adoption as a delivery vehicle for human and agricultural applications.
Emily M. Wessel, John M. Tomich, Richard B. Todd   +2 more
openaire   +3 more sources

Stabilization of Inverse Miniemulsions by Silyl-Protected Homopolymers

, 2016
Inverse (water-in-oil) miniemulsions are an important method to encapsulate hydrophilic payloads such as oligonucleotides or peptides. However, the stabilization of inverse miniemulsions usually requires block copolymers that are difficult to synthesize ...
Crespy, D., Landfester, K., Wald, S., Wurm, F.   +3 more
core   +2 more sources