Results 121 to 130 of about 69,654 (255)

Organic Nanozyme‐Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression

Advanced Science, EarlyView.
A temperature‐sensitive hydrogel loaded with cyanine nanozymes and Escherichia coli is locally injected into postoperative tumor resection beds. Upon light irradiation, synergistic PTT and PDT work with cascaded reactive oxygen species to deplete extracellular GSH, eliminate residual tumor cells, and induce robust antitumor immune responses for ...
Cong Jiang, Zifan Yang, Rong Guo, Meng Suo, Guowei Wang, Dong Chen, Lilin Su, Fuhuan Wang, Shipeng Ning, Kelong Fan, Xuan Wang   +10 more
wiley   +1 more source

The Application of Thermosensitive Nanocarriers in Controlled Drug Delivery

, 2011
Thermosensitive nanocarriers as the “smart” drug delivery systems have shown tremendous promise in the field of controlled drug delivery due to their special property.
Jun Li, Yazhou Wang, Yiqiong Zhang, Bochu Wang, Pengyu Shao   +4 more
core   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

New nanocarriers for the delivery of old antibiotics: spectroscopic study of the affinity of the drugs

, 2015
The slogan of the World Health Day in 2011 was "Antimicrobial resistance: no action today no cure tomorrow".1 Developing new antibiotics is mandatory but takes years.
Jitendra Wankar, Giuseppina Salzano, Ruxandra Gref, Ilse Manet, Elisabetta Pancani   +4 more
core  

Transportan in nanocarriers improves skin localization and antitumor activity of paclitaxel [PDF]

, 2016
Dominique Pepe,1 Vanessa FM Carvalho,2 Melissa McCall,1 Débora P de Lemos,2 Luciana B Lopes1,2 1Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, NY, USA; 2Department of Pharmacology, Institute of ...
McCall M, Lopes LB, Pepe D, Carvalho VFM, de Lemos DP   +4 more
core  

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs

Advanced Science, EarlyView.
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang, Hui Wang, Hao Zhang, Zhenkuan Cao, Zehui Liu, Siying Li, Hongda Wang, Yuping Shan   +7 more
wiley   +1 more source

Polysaccharides as a Hydrophilic Building Block of Amphiphilic Block Copolymers for the Conception of Nanocarriers

Pharmaceutics
Polysaccharides are gaining increasing attention for their relevance in the production of sustainable materials. In the domain of biomaterials, polysaccharides play an important role as hydrophilic components in the design of amphiphilic block copolymers
Aijing Lu, Suming Li
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source