Results 131 to 140 of about 69,654 (255)

Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases

, 2008
Malgorzata Smola1,2, Thierry Vandamme1, Adam Sokolowski21Université Louis Pasteur, Faculté de Pharmacie, Département de Chimie Bioorganique, Illkirch Graffenstaden, France; 2Wroclaw University of Technology, Faculty of ...
Thierry Vandamme, Adam Sokolowski, Malgorzata Smola   +2 more
core  

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies

, 2018
Marcelle Silva-Abreu,1,2 Ana Cristina Calpena,1,2 Pol Andrés-Benito,3,4 Ester Aso,3,4 Ignacio A Romero,5 David Roig-Carles,5 Radka Gromnicova,5 Marta Espina,1,2 Isidre Ferrer,3,4 María Luisa García,1,2 David Male5 1Department of ...
Espina M, Ferrer I, Silva-Abreu M, Gromnicova R, Roig-Carles D, Aso E, García ML, Romero IA, Calpena AC, Andrés-Benito P, Male D   +10 more
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Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Effect of Surface Charge of Amphiphlic Chitosan Nanocarriers on Drug Release Behavior

, 2012
Effect of Surface Charge of Amphiphlic Chitosan Nanocarriers on Drug Release ...
周火飞, 刘袖洞, 马小军, 于炜婷   +3 more
core  

Hyperthermic nanocarriers for biomedical applications

, 2019
Hyperthermic nanocarriers have been used for different biomedical ...
Stefano Tambalo, Silvia Mannucci, Concepción Jiménez López, GEROSA, MARCO, Federico Boschi, Laura Calderan., Davide Prosperi, Massimiliano Perduca, Maria Rosaria Marinozzi, Alice Busato, Manuela Malatesta, Federica Vurro   +11 more
core   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

, 2016
Ibrahim M Abdulbaqi, Yusrida Darwis, Nurzalina Abdul Karim Khan, Reem Abou Assi, Arshad A Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia Abstract: Ethosomal systems are novel lipid vesicular carriers containing a ...
Assi RA, Khan AA, Darwis Y, Khan NAK, Abdulbaqi IM   +4 more
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