Results 161 to 170 of about 12,080 (272)

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai   +9 more
wiley   +1 more source

Cinnamaldehyde From Cinnamon as a Food‐Derived Bioactive: Phytochemistry, Anticancer Mechanisms, Bioavailability, Nanoformulation and Safety

open access: yesFood Frontiers, Volume 7, Issue 5, September 2026.
Cinnamaldehyde derived from Cinnamomum species exerts multitarget anticancer effects by promoting oxidative stress, mitochondrial dysfunction, apoptosis, cell‐cycle arrest, autophagy, and epigenetic changes, and by suppressing mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase/protein kinase B/mechanistic target of rapamycin (PI3K/Akt ...
Gervason Moriasi   +6 more
wiley   +1 more source

Optimization of Physicochemical Properties of Chitosan–Gum Arabic Nanoparticles Containing Ziziphora clinopodioides Lam. Extract Using Response Surface Methodology

open access: yesFood Science &Nutrition, Volume 14, Issue 9, September 2026.
This study outlines the preparation of Chs‐GA‐NPs loaded with ZcEx. Dried leaves of the plant were powdered and extracted using an aqueous‐ethanolic method. Chitosan, GA, and Tween‐80 solutions were mixed to form a nanoemulsion, followed by the addition of the plant extract and TPP solution under stirring, which triggered ionic gelation and produced ...
Anita Ehterami   +4 more
wiley   +1 more source

Biomimetic mineralization‐inspired formulation‐adjuvant integrated circRNA nanovaccine against COVID‐19

open access: yesInterdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin   +10 more
wiley   +1 more source

Brazilian Red Propolis Nanoparticles: In Vitro Anticancer Effects in Female‐Associated Malignancies and In Vivo Toxicity in an Alternative Model

open access: yesJournal of Biomedical Materials Research Part A, Volume 114, Issue 9, September 2026.
ABSTRACT This study explores the development and characterization of polymeric nanoparticles encapsulating Brazilian red propolis extract (BRPE) for application in ovarian (OVCAR‐3) and breast (MDA‐MB‐231) cancers. The nanoparticles (NCBRPE), produced by nanoprecipitation, were evaluated for size, polydispersity index (PdI), zeta potential, and ...
Isabela A. Justino   +9 more
wiley   +1 more source

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