Results 1 to 10 of about 1,151 (165)

Pharmacokinetic Comparison between Methotrexate-Loaded Nanoparticles and Nanoemulsions as Hard- and Soft-Type Nanoformulations: A Population Pharmacokinetic Modeling Approach

Pharmaceutics, 2021
The purpose of this study was to identify and explore the differences in pharmacokinetics between different nanoformulations. This was done by comparing the pharmacokinetics of methotrexate-loaded nanoparticles [poly(lactic-co-glycolic acid); size of 163.
Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee   +2 more
doaj   +1 more source

Nanoformulation of Plant-Based Natural Products for Type 2 Diabetes Mellitus: From Formulation Design to Therapeutic Applications

Current Therapeutic Research, 2022
Background: Herbal remedies are used to manage type 2 diabetes mellitus (type 2 DM) as the sole treatment or as a complementary therapy. Limitations of herbal remedies, such as poor stability and limited absorption, impede their development as ...
Akurange Sujeevi Dammadinna Wickramasinghe, Pabasara Kalansuriya, Anoja Priyadarshani Attanayake   +2 more
doaj   +1 more source

Reconstructing Tumor Microenvironment Using Photoresponsive Cyanobacteria to Reversal Chemoresistance for Robust Chemotherapy

Small Structures, 2023
The solid tumor microenvironment (TME) plays a crucial role in tumor biological behavior, development, and chemoresistance. Herein, a promising strategy is reported to remodel the TME and combat chemoresistance by employing the photoresponsive ...
Huamei He, Denghui Zhu, Aiqing Ma, Jian Ren, Ze Chen, Hui Ran, Zhaozhen Li, Ruiqing Qin, Ruijing Liang, Lanlan Liu, Lintao Cai   +10 more
doaj   +1 more source

Synthesis of Copper Oxide-Based Nanoformulations of Etoricoxib and Montelukast and Their Evaluation through Analgesic, Anti-Inflammatory, Anti-Pyretic, and Acute Toxicity Activities

Molecules, 2022
Copper oxide nanoparticles (CuO NPs) were synthesized through the coprecipitation method and used as nanocarriers for etoricoxib (selective COX-2 inhibitor drug) and montelukast (leukotriene product inhibitor drug) in combination therapy.
Sulaiman Sulaiman, Shabir Ahmad, Syeda Sohaila Naz, Sara Qaisar, Sayyar Muhammad, Amal Alotaibi, Riaz Ullah   +6 more
doaj   +1 more source

Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor

Bioactive Materials, 2021
The adoptive transfer of chimeric antigen receptor-T (CAR-T) cells has shown remarkable clinical responses in hematologic malignancies. However, unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.
Hong Pan, Wenjun Li, Ze Chen, Yingmei Luo, Wei He, Mengmeng Wang, Xiaofan Tang, Huamei He, Lanlan Liu, Mingbin Zheng, Xin Jiang, Ting Yin, Ruijing Liang, Yifan Ma, Lintao Cai   +14 more
doaj   +1 more source

Nematicidal Properties of Chitosan Nanoformulation

Journal of Nematology, 2023
Abstract Chitosan is the second most abundant bio-polymer available in the world, second only to cellulose. It is found in crustaceous shells, e.g., those of crabs, shrimps, prawns, and fungi, as well as insect exoskeletons.
Mouniga R., Anita B., Lakshmanan A., Shanthi A., Karthikeyan G.   +4 more
openaire   +3 more sources

Glucocorticoid nanoformulations relieve chronic pelvic pain syndrome and may alleviate depression in mice

Journal of Nanobiotechnology, 2023
Background Chronic pelvic pain syndrome (CPPS) is a typical symptom of chronic prostatitis (CP) in males that may cause abnormal urination, sexual dysfunction, or depression and significantly affect the quality of life of the patient. Currently, there is
Yang Yang, Ruimin Hu, Jun Zheng, Qianmei Wang, Senlin Xu, Zhansong Zhou, Dinglin Zhang, Wenhao Shen   +7 more
doaj   +1 more source

Nanoformulations for molecular MRI [PDF]

WIREs Nanomedicine and Nanobiotechnology, 2012
AbstractNanoscale contrast agents have shown the ability to increase the detection sensitivity of magnetic resonance imaging (MRI) by several orders of magnitude, endowing this traditionally macroscopic modality with the ability to observe unique molecular signatures.
Chuqiao, Tu, Angelique Y, Louie
openaire   +2 more sources

Nanoparticle-Guided Brain Drug Delivery: Expanding the Therapeutic Approach to Neurodegenerative Diseases

Pharmaceutics, 2021
Neurodegenerative diseases (NDs) represent a heterogeneous group of aging-related disorders featured by progressive impairment of motor and/or cognitive functions, often accompanied by psychiatric disorders.
Claudia Riccardi, Filomena Napolitano, Daniela Montesarchio, Simone Sampaolo, Mariarosa Anna Beatrice Melone   +4 more
doaj   +1 more source

Progress on the Application of Bortezomib and Bortezomib-Based Nanoformulations

Biomolecules, 2021
Bortezomib (BTZ) is the first proteasome inhibitor approved by the Food and Drug Administration. It can bind to the amino acid residues of the 26S proteasome, thereby causing the death of tumor cells.
Jianhao Liu, Ruogang Zhao, Xiaowen Jiang, Zhaohuan Li, Bo Zhang   +4 more
doaj   +1 more source