Results 1 to 10 of about 14,638 (259)

Pharmacokinetic Comparison between Methotrexate-Loaded Nanoparticles and Nanoemulsions as Hard- and Soft-Type Nanoformulations: A Population Pharmacokinetic Modeling Approach

Pharmaceutics, 2021
The purpose of this study was to identify and explore the differences in pharmacokinetics between different nanoformulations. This was done by comparing the pharmacokinetics of methotrexate-loaded nanoparticles [poly(lactic-co-glycolic acid); size of 163.
Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee   +2 more
doaj   +2 more sources

Glucocorticoid nanoformulations relieve chronic pelvic pain syndrome and may alleviate depression in mice

Journal of Nanobiotechnology, 2023
Background Chronic pelvic pain syndrome (CPPS) is a typical symptom of chronic prostatitis (CP) in males that may cause abnormal urination, sexual dysfunction, or depression and significantly affect the quality of life of the patient. Currently, there is
Yang Yang, Ruimin Hu, Jun Zheng, Qianmei Wang, Senlin Xu, Zhansong Zhou, Dinglin Zhang, Wenhao Shen   +7 more
doaj   +2 more sources

The Multifaceted Mechanistic Actions of Antimicrobial Nanoformulations: Overcoming Resistance and Enhancing Efficacy [PDF]

Pharmaceutics
Antimicrobial resistance represents one of the most formidable global health crises of the 21st century, driven by the diminishing efficacy of conventional antibiotics due to bacterial adaptation and biofilm formation.
Renuka Gudepu, Ramadevi Kyatham, Nirmala Devi Ediga, Geetha Penta, Raju Bathula, Mohammed Mujahid Alam, Mounika Sarvepalli, Jayarambabu Naradala, Vikram Godishala, Swati Dahariya, Aditya Velidandi   +10 more
doaj   +2 more sources

Recent developments in quercetin nanomedicine and applications in osteoarthritis and rheumatoid arthritis therapies [PDF]

Frontiers in Pharmacology
Quercetin has attracted increasing attention in the research of treatments for rheumatoid arthritis and osteoarthritis due to its excellent anti-inflammatory, antioxidant, and joint-protective effects.
Yuan Zhu, Hongxuan Chen, Yuanling Yi, Fuhui Zhou, Wenzhi Zhou, Shenghui Zhong   +5 more
doaj   +2 more sources

Impact of Mint and Clove Extract (Nanoformulations) on Functional Yoghurt Properties [PDF]

Journal of Food and Dairy Sciences, 2023
Study investigates  the effect of nanoformulations of clove and mint extract on functional yoghurt's microbiological, phenolic, and sensory properties.
M. Abo-Srea, Asmaa El-Awady, Ola Shalabi, Huda Yossif   +3 more
doaj   +1 more source

Nanoformulation of Plant-Based Natural Products for Type 2 Diabetes Mellitus: From Formulation Design to Therapeutic Applications

Current Therapeutic Research, 2022
Background: Herbal remedies are used to manage type 2 diabetes mellitus (type 2 DM) as the sole treatment or as a complementary therapy. Limitations of herbal remedies, such as poor stability and limited absorption, impede their development as ...
Akurange Sujeevi Dammadinna Wickramasinghe, Pabasara Kalansuriya, Anoja Priyadarshani Attanayake   +2 more
doaj   +1 more source

Reconstructing Tumor Microenvironment Using Photoresponsive Cyanobacteria to Reversal Chemoresistance for Robust Chemotherapy

Small Structures, 2023
The solid tumor microenvironment (TME) plays a crucial role in tumor biological behavior, development, and chemoresistance. Herein, a promising strategy is reported to remodel the TME and combat chemoresistance by employing the photoresponsive ...
Huamei He, Denghui Zhu, Aiqing Ma, Jian Ren, Ze Chen, Hui Ran, Zhaozhen Li, Ruiqing Qin, Ruijing Liang, Lanlan Liu, Lintao Cai   +10 more
doaj   +1 more source

Synthesis of Copper Oxide-Based Nanoformulations of Etoricoxib and Montelukast and Their Evaluation through Analgesic, Anti-Inflammatory, Anti-Pyretic, and Acute Toxicity Activities

Molecules, 2022
Copper oxide nanoparticles (CuO NPs) were synthesized through the coprecipitation method and used as nanocarriers for etoricoxib (selective COX-2 inhibitor drug) and montelukast (leukotriene product inhibitor drug) in combination therapy.
Sulaiman Sulaiman, Shabir Ahmad, Syeda Sohaila Naz, Sara Qaisar, Sayyar Muhammad, Amal Alotaibi, Riaz Ullah   +6 more
doaj   +1 more source

Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor

Bioactive Materials, 2021
The adoptive transfer of chimeric antigen receptor-T (CAR-T) cells has shown remarkable clinical responses in hematologic malignancies. However, unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.
Hong Pan, Wenjun Li, Ze Chen, Yingmei Luo, Wei He, Mengmeng Wang, Xiaofan Tang, Huamei He, Lanlan Liu, Mingbin Zheng, Xin Jiang, Ting Yin, Ruijing Liang, Yifan Ma, Lintao Cai   +14 more
doaj   +1 more source

Nanoparticle-Guided Brain Drug Delivery: Expanding the Therapeutic Approach to Neurodegenerative Diseases

Pharmaceutics, 2021
Neurodegenerative diseases (NDs) represent a heterogeneous group of aging-related disorders featured by progressive impairment of motor and/or cognitive functions, often accompanied by psychiatric disorders.
Claudia Riccardi, Filomena Napolitano, Daniela Montesarchio, Simone Sampaolo, Mariarosa Anna Beatrice Melone   +4 more
doaj   +1 more source