Results 51 to 60 of about 14,638 (259)
PharmaceuticsBackground/Objectives: Glioblastoma multiforme (GBM) therapy efficacy remains limited due to the poor blood-brain barrier-penetrating power of drugs as well as dysregulated cellular signaling pathways of tumor cells leading to drug resistance. Novel drug
Anna Rybarczyk +3 more
doaj +1 more source
Advanced Science, EarlyView.We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen +5 more
wiley +1 more source
Physiochemical characterization of nanoformulations.
, 2012 Size of NPs (a) was measured by DLS. (b) TEM analysis of drug loaded NPs depicting the spherical nature of the nanoformulation. Scale bar is 100 nm. (c and d) Sustain release phenomenon exhibited by drug loaded nanoformulations.
Manasi Das (176472) +1 more
core +1 more source
Curcumin nanoformulations with antimicrobial activity
, 2023 Kurkumin, polifenol izoliran iz biljke Curcuma longa, potencijalni je kandidat za terapiju različitih bolesti zahvaljujući svojem antimikrobnom, antikancerogenom i antioksidativnom učinku. Međutim, loša fizikalno-kemijska svojstva poput slabe topljivosti
Osmak, Lucija
core +1 more source
Advanced Science, EarlyView.This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen +14 more
wiley +1 more source
Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs
Frontiers in Neuroscience, 2020 Central nervous system (CNS) disorders especially neurodegenerative disorders are the major challenge for public health and demand the great attention of researchers to protect people against them. In past few decades, different treatment strategies have
Saba Naqvi +2 more
doaj +1 more source
Intricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum
Drug Delivery, 2023 It is evident that site-specific systemic drug delivery can reduce side effects, systemic toxicity, and minimal dosage requirements predominantly by delivering drugs to particular pathological sites, cells, and even subcellular structures.
Koyeli Girigoswami +2 more
doaj +1 more source
Advanced Science, EarlyView.This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori +10 more
wiley +1 more source
, 2023 AIM: Herein, the anti-parasitic activity of azoles (fluconazole and itraconazole) and 5-nitroimdazole (metronidazole) against the brain-eating amoebae: Naegleria fowleri and Balamuthia mandrillaris was elucidated.METHODS AND RESULTS: Azoles and 5 ...
Siddiqui, Ruqaiyyah; id_orcid +5 more
core +1 more source
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source