Results 81 to 90 of about 14,638 (259)

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Recent advancement of fisetin-based nanoformulations in the management of psoriasis

Discover Nano
Psoriasis is a chronic inflammatory autoimmune skin disease with enhanced skin cell turnover. Despite the therapies currently available, better and target-oriented therapies are needed.
Umesh B. Telrandhe, Anjum N. Hasnain, Sachin N. Kothawade, Darshan R. Telange   +3 more
doaj   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

In vitro analysis of PARP inhibitor nanoformulations

, 2018
Paige Baldwin,1 Shifalika Tangutoori,1,2 Srinivas Sridhar1,2 1Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA; 2Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA, USA Abstract: PARP-l is a ...
Sridhar S, Tangutoori S, Baldwin P
core  

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective

, 2017
Yasamin Davatgaran-Taghipour,1,2 Salar Masoomzadeh,3 Mohammad Hosein Farzaei,4,5 Roodabeh Bahramsoltani,6 Zahra Karimi-Soureh,7 Roja Rahimi,6,8 Mohammad Abdollahi9,10 1Department of Medical Nanotechnology, School of Advanced Technologies in Medicine ...
Rahimi R, Abdollahi M, Karimi-Soureh Z, Davatgaran-Taghipour Y, Masoomzadeh S, Bahramsoltani R, Farzaei MH   +6 more
core  

Novel erythromycin lipid nanoformulations for aquaculture applications

AIMS: This study introduces novel lipid nanoformulations of erythromycin (ERY) designed for aquaculture pathogens and evaluates their in vitro antimicrobial activity compared to pure ERY.
Sasanya, James Jacob, da Silva, Agnaldo Fernando Baldo, Pilarski, Fabiana [UNESP], Gil, Gabriela Alberto, Campanharo, Sarah Chagas, Assane, Inácio Mateus [UNESP], de Oliveira, Wanderley Pereira, Paschoal, Jonas Augusto Rizzato, de Abreu Reis Ferreira, Daniel [UNESP]   +8 more
core   +1 more source

Nanoformulations of α-Mangostin for Cancer Drug Delivery System

, 2021
Natural compounds are emerging as effective agents for the treatment of malignant diseases. The active constituent of α-mangostin from the pericarp of Garcinia mangostana L.
Muchtaridi Muchtaridi, Lisna Meylina, Ahmed Fouad Abdelwahab Mohammed, I Made Joni, Nasrul Wathoni   +4 more
core   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Challenges and Opportunities in COPD Management in Latin America: A Review of Inhalation Therapies and Advanced Drug Delivery Systems

Pharmaceutics
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, particularly in low- and middle-income countries, where it poses a significant burden.
Juan S. Izquierdo-Condoy, Camila Salazar-Santoliva, Daniel Salazar-Duque, Yorlenis-Del-Carmen Palacio-Dávila, Juan M. Hernández-Londoño, Rafael Orozco-Gonzalez, María-Silvana Rodríguez-Sánchez, Valentina Marín-Bedoya, Valentina Loaiza-Guevara   +8 more
doaj   +1 more source