Results 91 to 100 of about 12,558 (240)

Nanogel formation of polymer solutions flowing through porous media [PDF]

, 2012
A gelation process was seen to occur when Boger fluids made from aqueous solutions of polyacrylamide (PAA) and NaCl flowed through porous media with certain characteristics.
Alves, Manuel A., Campo-Deaño, Laura, Galindo-Rosales, Francisco J, Oliveira, Monica, Pinho, Fernando T.   +4 more
core   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Coenzyme-A-Responsive Nanogel-Coated Electrochemical Sensor for Osteoarthritis-Detection-Based Genetic Models

Gels
An electrochemical sensor sensitive to coenzyme A (CoA) was designed using a CoA-responsive polyallylamine–manganese oxide–polymer dot nanogel coated on the electrode surface to detect various genetic models of osteoarthritis (OA).
Akhmad Irhas Robby, Songling Jiang, Eun-Jung Jin, Sung Young Park   +3 more
doaj   +1 more source

Chitosan-myristate nanogel as an artificial chaperone protects neuroserpin from misfolding

Advanced Biomedical Research, 2016
Background: Molecular chaperon-like activity for protein refolding was studied using nanogel chitosan-myristic acid (CMA) and the protein neuroserpin (NS), a member of the serine proteinase inhibitor superfamily (serpin).
Habib Nazem, Afshin Mohsenifar, Sahar Majdi   +2 more
doaj   +1 more source

Bio-inspired pulmonary surfactant-modified nanogels : a promising siRNA delivery system [PDF]

, 2015
Inhalation therapy with small interfering RNA (siRNA) is a promising approach in the treatment of pulmonary disorders. However, clinical translation is severely limited by the lack of suitable delivery platforms.
Braeckmans, Kevin, De Backer, Lynn, De Smedt, Stefaan, Demeester, Jo, Raemdonck, Koen, Stuart, Marc CA   +5 more
core   +3 more sources

Self‐Assembled Myricetin‐Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Carrier‐free myricetin‐arginine conjugate nanozymes (MANZs) have been fabricated through a Mannich reaction and spontaneous self‐assembly. MANZs selectively accumulate in inflamed joints by targeting M1 macrophages via CAT2‐mediated uptake. The nanozymes can effectively modulate macrophage polarization, suppress osteoclast differentiation, and mitigate
Jiachang Hong, Penghao Ji, Jinxi An, Junchao Huang, Ziheng Bu, Xudong Zhang, Wei Liu, Tingyu Wu, Sen Wang, Wei Zhu, Yuhui Li, Jixian Wan, Sudan Xu, Minfeng Huo, Peng Wu   +14 more
wiley   +1 more source

Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels [PDF]

, 2012
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups ...
Anderson, Daniel Griffith, Chyan, Yieu, Doloff, Joshua C, Heller, Daniel A., Jiang, Shan, Kohane, Daniel S., Langer, Robert S, Levi, Yair, Manzano, Miguel, Pelet, Jeisa, Pratt, George W., Querbes, William, Sahay, Gaurav, Schroeder, Avraham Dror, Schroeder, Josh E., Wallas, Jasmine, Zurenko, Christopher   +16 more
core   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Preparation and Physicochemical Characterization of Hyaluronic Acid-Lysine Nanogels Containing Serratiopeptidase to Control Biofilm Formation

Scientific Reports
Remarkable resistance of bacterial biofilms to high doses of antimicrobials and antibiotics is one of their main challenges. Encapsulation of proteolytic enzymes is one of the suggested strategies to tackle this problem. In this regard, the antibacterial
Hanieh Mahdiani, Faegheh Yazdani, Mahsa Khoramipour, Vahideh Valizadeh, Haleh Bakhshandeh, Rassoul Dinarvand   +5 more
doaj   +1 more source

Formulation and evaluation of ketoprofen loaded chitosan nanogel for pain management: Ex-vivo and In-vivo study

Ars Pharmaceutica
Purpose: The purpose of this study was to develop and evaluate nanoemulsion-based gel (nanogel) for transdermal delivery of ketoprofen. Among the various excipients tested, oleic acid, tween 80 and ethanol were selected as oil, surfactant, and co ...
Inayat Bashir Pathan, Rashmi Dwivedi, Wahid Ambekar   +2 more
doaj   +1 more source