Results 101 to 110 of about 9,117 (234)

Biomaterial Platforms for Spatiotemporal Control of mRNA Delivery in Tissue Engineering and Regenerative Medicine: Design Rules, Therapeutic Applications, and Translational Roadmap

Small, EarlyView.
Biomaterial platforms can control where and when mRNA‐encoded proteins are expressed to support tissue repair. This Review proposes a cargo–target–timing framework linking therapeutic function, target tissues and cells, and expression profiles with carrier and scaffold design.
Huachun Pan, Shumin Yang, Katarina Holubova, Huifang Yin, Hongbo Chen, Xintian Zheng, Xiangan Han, Jinqiu Zhang, Xueping Li, Hui Zhang, Xiaojun Cai, Václav Slovák, Lihong Zhang, Quan Mo, Quazi T. H. Shubhra   +14 more
wiley   +1 more source

Self-Assembled Nanogels of Cholesterol-Bearing Hydroxypropyl Cellulose: A Thermoresponsive Building Block for Nanogel Tectonic Materials

, 2016
Hydroxypropyl cellulose (HPC) is a fascinating polysaccharide to use in developing a nanogel to be a thermoresponsive building unit for nanogel tectonic materials.
Tomoki Nishimura (463873), Kazunari Akiyoshi (496091), Shin-ichi Sawada (1615993), Yoshihiro Sasaki (594348), Shigeo Takeda (3132201), Yoshiro Tahara (1747285), Mizuki Sakiyama (3132198), Sada-atsu Mukai (1615990)   +7 more
core   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Glutathione-degradable drug-loaded nanogel effectively and securely suppresses hepatoma in mouse model

, 2015
Xingang Liu,1 Jianmeng Wang,2 Weiguo Xu,3 Jianxun Ding,3 Bo Shi,4 Kexin Huang,4 Xiuli Zhuang,3 Xuesi Chen31Department of Critical Care Medicine, 2Department of Geriatrics, The First Hospital of Jilin University, 3Key Laboratory of Polymer ...
Wang JM, Huang KX, Ding JX, Shi B, Zhuang XL, Chen XS, Liu XG, Xu WG   +7 more
core  

Supramolecular assembled nanogel made of mannan

, 2011
The supramolecular assembly of amphiphilic mannan, synthesized by the Michael addition of hydropho- bic 1-hexadecanethiol to vinyl methacrylated mannan, originates in aqueous medium the formation of a nanogel, stabilized by hydrophobic interactions ...
Rodrigues Mendes Ferreira, Silvia Ferreira, Gama, F. M., Sílvia A. Ferreira, Sampaio, Paula, Coutinho, Paulo J. G., Ferreira, Sílvia A., Pereira, Paula, Paula Pereira, Paulo J.G. Coutinho, Paula Sampaio, Francisco M. Gama, Coutinho, Paulo, Gama, Francisco M.   +12 more
core   +1 more source

Engineering Catalytic Biomaterials for Cellular Fate Modulation

Angewandte Chemie Novit, Volume 2, Issue 4, December 2026.
Catalytic biomaterials actively reprogram cell fate by converting endogenous biochemical cues or external stimuli into localized catalytic outputs. Through regulation of redox balance, organelle homeostasis, metal‐ion metabolism, and inflammatory signaling, they bidirectionally modulate regulated cell death and immune responses for disease treatment ...
Baoying Xu, Chenyao Wu, Dehong Yu, Wei Feng, Yu Chen   +4 more
wiley   +1 more source

Optimisation of Topical and Transdermal Pharmaceutical Formulations: Methods, Challenges and Opportunities

SmartSys, Volume 2, Issue 4, December 2026.
ABSTRACT Topical and transdermal pharmaceutical formulations are a large and diverse class of products, yet their optimisation remains a complex, resource‐intensive challenge. Statistical design‐of‐experiments approaches have long provided the methodological backbone for this process and have shown broad effectiveness across topical and transdermal ...
Yongrui Xiao, Yu Zhang, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Effect of nanohydrogel-containing Ferula gummosa resin on Streptococcus mutans and Candida albicans [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects
Background. Integrating nanoparticles with herbal medicine can enhance drug efficacy and leverage natural antimicrobial properties, addressing concerns related to drug side effects and microbial resistance.
Shima Golmohammadi, Behnaz Daraei, Ali Basir, Marzieh Rashidipour   +3 more
doaj   +1 more source

Shikonin: From Biosynthesis and Pharmacological Mechanisms to Translational Safety and Drug Delivery

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Shikonin, biosynthesised in Boraginaceae roots from phenylalanine‐derived PHB and isoprenoid GPP, modulates redox balance, cellular stress, signalling pathways, and regulated cell death. Preclinical studies support diverse pharmacological activities, while nanocarriers improve dispersion and delivery.
Namini Joshi, Prabhakar Semwal, Balwant Rawat, Ravendra Kumar, Mozaniel Santana de Oliveira, Nishant Rai, Janhvi Mishra Rawat   +6 more
wiley   +1 more source

Nano MIPs (Molecularly Imprinted Polymers) Prepared From a “Frustrated” Gold Nanoparticle‐Based Pre‐Imprinting Matrix: Enhancing Binding Affinity and Selectivity

Chemistry – A European Journal, Volume 32, Issue 41, 3 November 2026.
A comparative study across ligand‐stabilized gold nanoparticles and surfactant micelles reveals that molecular imprinting strongly depends on the nanoplatform used for imprinting. “Frustrated” noncovalent interactions within the monolayer on gold nanoparticle surface can be exploited to improve both the binding affinity and selectivity for ...
Mansi Sharma, Dashaunette D. Wallace, Yan Zhao   +2 more
wiley   +1 more source