Results 91 to 100 of about 9,117 (234)
Phytotherapy Research, EarlyView.Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li +14 more
wiley +1 more source
In Vivo GFP Knockdown by Cationic Nanogel-siRNA Polyplexes
Bioengineering, 2015 RNA interference (RNAi) is a powerful tool to treat diseases and elucidate target gene function. Prior to clinical implementation, however, challenges including the safe, efficient and targeted delivery of siRNA must be addressed.
Arun R. Shrivats +4 more
doaj +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Rheumatoid arthritis (RA) is an autoimmune condition marked by joint inflammation, cartilage destruction, and bone damage. Conventional treatments, including NSAIDs and DMARDs, have shown effectiveness in slowing down disease progression, but prolonged exposure to such medications results in adverse effects and lack of tolerance among patients.
Yogesh Khairnar +5 more
wiley +1 more source
Chitosan-myristate nanogel as an artificial chaperone protects neuroserpin from misfolding
Advanced Biomedical Research, 2016 Background: Molecular chaperon-like activity for protein refolding was studied using nanogel chitosan-myristic acid (CMA) and the protein neuroserpin (NS), a member of the serine proteinase inhibitor superfamily (serpin).
Habib Nazem +2 more
doaj +1 more source
Nanogels for intracellular delivery of biotherapeutics
Journal of Controlled Release, 2017 Many biomolecules, such as proteins and genes, are presently used as therapeutics. However, their delivery to target sites inside cells is challenging because of their large molecular size, difficulties to pass cellular membranes and their susceptibility for enzymatic and chemical degradation.
Li, Dandan +4 more
openaire +3 more sources
Small, EarlyView.Protein‐based multilayer microreactors combine single‐enzyme nanogels (SENs) and layer‐by‐layer (LbL) assembly to control catalase localization. Positioning the enzyme within the core or at different locations of the multilayer architecture reveals how spatial organization influences antioxidant and anti‐inflammatory activity.
Maria A. Motta +5 more
wiley +1 more source
Wrinkling Pickering Emulsions via Endospore Germination
Small, EarlyView.This study presents a method for creating Pickering emulsions with long shelf life using bacterial endospores as stabilizers. Upon exposure to favorable conditions, spores germinate, swelland trigger wrinkling on droplet surfaces. The resulting patterns depend on initial interfacial coverage, enabling the change of droplet morphology on demand.
Yiyao Hu +7 more
wiley +1 more source
Development of a hybrid dextrin hydrogel encapsulating dextrin nanogel as protein delivery system [PDF]
, 2012 Dextrin, a glucose polymer with low molecular weight, was used to develop a fully resorbable hydrogel, without using chemical initiators. Dextrin was first oxidized (oDex) with sodium periodate and then cross-linked with adipic acid dihidrazide, a ...
Molinos, Maria +7 more
core +1 more source
Metal-ion-coordinated silk fibroin nanogels for enhanced oral chemotherapy of colorectal cancer
Journal of NanobiotechnologyThe efficacy of oral chemotherapy for colorectal cancer (CRC) is hampered by poor drug stability and absorption in the upper gastrointestinal tract, as well as inadequate targeting efficiency at tumor sites.
Baoyi Li +11 more
doaj +1 more source
Artificial Cells, Nanomedicine, and Biotechnology, 2019 The evolution of drug resistance of Candida species to conventional antifungal agents has been a major medical challenge worldwide; attempt to use the potential antifungal agents with appropriate therapy efficacy and minimum effects is considerably ...
Fatemeh Nikoomanesh +4 more
doaj +1 more source