Results 171 to 180 of about 4,614 (205)

Polyplex nanomicelle delivery of self-amplifying RNA vaccine

Journal of Controlled Release, 2021
Self-amplifying RNA (SaRNA) is a burgeoning platform that exploits the replication machinery of alphaviruses such as Venezuelan equine encephalitis (VEE) virus or Sindbis virus (SIN). SaRNA has been used for development of human vaccines, but has not been evaluated for porcine vaccine development.
Yi-Hao, Chang, Mei-Wei, Lin, Ming-Chen, Chien, Guan-Ming, Ke, I-En, Wu, Ren-Li, Lin, Chin-Yu, Lin, Yu-Chen, Hu   +7 more
openaire   +2 more sources

Functionalization of polymeric nanomicelles and mixed nanomicelles for targeted retinal delivery in the management of retinoblastoma

International Journal of Pharmaceutics
The current research discusses polymer conjugation, formulation development, and evaluation of sorafenib-loaded polymeric nanomicelles of conjugated soluplus (solu-tin) and polymeric mixed nanomicelles of conjugated soluplus (solu-tin) with conjugated poloxamer 188 (polo-tin) for site-specific posterior segment delivery to the retina in managing ...
Mudassir Ansari, Chandan Gupta, Yogesh A. Kulkarni, Kavita Singh   +3 more
openaire   +2 more sources

Anti-glioblastoma effects of nanomicelle-curcumin plus erlotinib

Food & Function, 2021
Glioblastoma (GBM), one of the most significant brain neoplasms, is characterized by high metastasis and recurrence.
Ali Bagherian, Bostan Roudi, Nahid Masoudian, Hamed Mirzaei   +3 more
openaire   +2 more sources

Casein nanomicelle as an emerging biomaterial—A comprehensive review

Colloids and Surfaces B: Biointerfaces, 2019
Casein nanomicelles, a major fraction of milk protein, are emerging as a novel drug delivery system owing to their various structural and functional properties. Casein is further divided into α-, β- and κ-casein, and to date various models have been proposed to describe casein structure, but still no definite structure presenting a detailed assembly of
Farah, Rehan, Nafees, Ahemad, Manish, Gupta   +2 more
openaire   +2 more sources

Prodrugs and nanomicelles to overcome ocular barriers for drug penetration

Expert Opinion on Drug Metabolism & Toxicology, 2020
Ocular barriers hinder drug delivery and reduce drug bioavailability. This article focuses on enhancing drug absorption across the corneal and conjunctival epithelium. Both, transporter targeted prodrug formulations and nanomicellar strategy is proven to enhance the drug permeation of therapeutic agents across various ocular barriers.
Vrinda Gote, Michael Ansong, Dhananjay Pal   +2 more
openaire   +2 more sources

Revolutionizing technologies of nanomicelles for combinatorial anticancer drug delivery

Archives of Pharmacal Research, 2020
Insufficient efficacy of current single drug therapy of cancers have led to the advancement of combination drug-loaded formulations. Specifically, polymeric micelles have been focused on as efficient injectable vehicles for the delivery of several anticancer drugs simultaneously to cancer cells.
Min Jeong, Jo, Ik Sup, Jin, Chun-Woong, Park, Bang Yeon, Hwang, Youn Bok, Chung, Jin-Seok, Kim, Dae Hwan, Shin   +6 more
openaire   +2 more sources

Study on lipid nanomicelles targeting placenta for the treatment of preeclampsia

Journal of Drug Targeting, 2022
In view of the serious clinical harm of preeclampsia and the lack of effective treatment methods, a PEG-modified lipid hybrid micelle was designed with a folic acid molecule on the surface, containing siRNA, targeted delivery to the placenta, interfering with the expression of sFlt-1 and treating preeclampsia.
Yang, Liu, Qimeng, Zhang, Xingli, Gao, Tong, Wang   +3 more
openaire   +2 more sources

Advances in nanomicelles for sustained drug delivery

Journal of Industrial and Engineering Chemistry, 2017
Abstract The efficient direct access of therapeutic molecules to the target tissues is still a major obstacle in developing useful therapeutic interventions. Over the past decades, polymeric micelles are interesting nanocarries for drug delivery systems due to small size (10–100 nm), low toxicity, capacity to solubilize lipophilic drugs in core and ...
Najmeh Amirmahani, Nosrat O. Mahmoodi, Mohsen Mohammadi Galangash, Atefeh Ghavidast   +3 more
openaire   +1 more source

Stimulus-Responsive Targeted Nanomicelles for Effective Cancer Therapy

Nanomedicine, 2009
Emerging nanotechnology has already developed various innovative nanomedicines. Nanomicelles, self-assemblies of block copolymers, are promising nanomedicines for targeted drug delivery and imaging. Stimulus-responsive targeted nanomicelles are designed to release drugs based on stimuli such as pH, temperature, redox potential, magnetism and ultrasound.
Madaswamy S Muthu, Amit Mishra
exaly   +3 more sources

The combination of nanomicelles with terpenes for enhancement of skin drug delivery

International Journal of Pharmaceutics, 2018
The nanomicelles have recently drawn a great deal of attention for drug delivery into the skin. However, these carriers have only deposited in hair follicles and furrows, and drug in the micelles may not therapeutically reach into viable skin layers.
Emine, Kahraman, Neşet, Neşetoğlu, Sevgi, Güngör, Duri Şehvar, Ünal, Yıldız, Özsoy   +4 more
openaire   +2 more sources