Results 131 to 140 of about 1,463,971 (275)

Spatiotemporal regulation of ventilator lung injury resolution by TGF-β1+ regulatory B cells via macrophage vesicle-nanotherapeutics

Frontiers in Immunology
BackgroundRegulatory B cells (Breg) critically orchestrate inflammatory resolution and tissue repair. This study investigates the therapeutic potential of transforming growth factor (TGF)-β1-producing Bregs in ventilator-induced lung injury (VILI ...
Ren Jing, Ren Jing, Xiaoting Liao, Xiaoting Liao, Xiaoting Liao, Xiaoting Liao, Jianlan Mo, Sheng He, Xianlong Xie, Zhaokun Hu, Zhaokun Hu, Zhaokun Hu, Zhaokun Hu, Linghui Pan, Linghui Pan, Linghui Pan, Linghui Pan   +16 more
doaj   +1 more source

MOFs and COFs in Electronics: Bridging the Gap between Intrinsic Properties and Measured Performance

Advanced Functional Materials, EarlyView.
Metal‐organic frameworks (MOFs) and covalent organic frameworks (COFs) hold promise for advanced electronics. However, discrepancies in reported electrical conductivities highlight the importance of measurement methodologies. This review explores intrinsic charge transport mechanisms and extrinsic factors influencing performance, and critically ...
Jonas F. Pöhls, R. Thomas Weitz
wiley   +1 more source

Comparative evaluation of ultrasound-assisted extraction and micelle-mediated extraction of bioactive compound from Acmella oleracea

Scientific Reports
This study compares two green extraction techniques: ultrasound-assisted extraction (UAE) and micelle-mediated extraction (MME) for isolating (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenamide (IBDTA) from Acmella oleracea.
Kunat Suktham, Suvimol Surassmo, Raweewan Thiramanas, Asdarina Yahya, Chaisak Chansriniyom, Duangporn Polpanich, Udom Asawapirom   +6 more
doaj   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Microbiome and actinobacterial community of mangrove ecosystem

Environmental Research Communications
Mangrove ecosystems harbor diverse microbial communities vital for ecosystem health. This study employed metagenomic and culture-based methods to compare bacterial communities across mangrove sediment, water, and terrestrial soil. Sediment samples showed
Trinset Weeraphan, Vichaya Gunbua, Supakit Srisawas, Somboon Tanasupawat, Wongsakorn Phongsopitanun, Paranee Sripreechasak   +5 more
doaj   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines

International Journal of Nanomedicine
Shanlei Zhou,1 Yu Zhang,1 Eudald Casals,2 Muling Zeng,3 Manuel Morales-Ruiz,4,5 Qingshi Liu,6 Bo Zhang,7 Gregori Casals4,8 1Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People’s Republic of China;
Zhou S, Zhang Y, Casals E, Zeng M, Morales-Ruiz M, Liu Q, Zhang B, Casals G   +7 more
doaj  

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

Ternary nanoparticles composed of cationic solid lipid nanoparticles, protamine, and DNA for gene delivery

International Journal of Nanomedicine, 2013
Sai-Nan He,1 Yun-Long Li,1,2 Jing-Jing Yan,2 Wei Zhang,2 Yong-Zhong Du,2 He-Yong Yu,1 Fu-Qiang Hu,2 Hong Yuan21Women’s Hospital, 2College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ...
He SN, Li YL, Yan JJ, Zhang W, Du YZ, Yu HY, Hu FQ ,Yuan H   +6 more
doaj  

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source