Results 11 to 20 of about 3,288 (209)

Intracellular Absolute Quantification of Oligonucleotide Therapeutics by NanoSIMS [PDF]

Analytical Chemistry, 2022
Antisense oligonucleotide (ASO)-based therapeutics hold great potential for the treatment of a variety of diseases. Therefore, a better understanding of cellular delivery, uptake, and trafficking mechanisms of ASOs is highly important for early-stage drug discovery.
Cécile Becquart, Rouven Stulz, Aurélien Thomen, Maryam Dost, Neda Najafinobar, Anders Dahlén, Shalini Andersson, Andrew G. Ewing, Michael E. Kurczy   +8 more
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NanoSIMS analysis of arsenic and selenium in cereal grain [PDF]

New Phytologist, 2009
*Cereals are an important source of selenium (Se) to humans and many people have inadequate intakes of this essential trace element. Conversely, arsenic (As) is toxic and may accumulate in rice grain at levels that pose a health risk. Knowledge of the localization of selenium and arsenic within the cereal grain will aid understanding of their ...
Moore, K, Schröder, M, Lombi, E, Zhao, F, Zhao, F, McGrath, S, Hawkesford, M, Shewry, P, Grovenor, C   +8 more
openaire   +7 more sources

NanoSIMS determination of the water content of staurolite [PDF]

Rapid Communications in Mass Spectrometry, 2022
Staurolite is an important mineral that can reveal much about metamorphic processes. For instance, it dominates the Fe-Mg exchange reactions in amphibolite-facies rocks between about 550 and 700 °C, and can be also found at suprasolidus conditions. Staurolite contains a variable amount of OH in its structure, whose determination is a key petrological ...
Azevedo-Vannson, Samantha, Remusat, Laurent, Bureau, Hélène, Béneut, Keevin, Cesare, Bernardo, Khodja, Hicham, Jiménez-Mejías, María, Roskosz, Mathieu   +7 more
core   +7 more sources

NanoSIMS and EPMA dating of lunar zirconolite [PDF]

Progress in Earth and Planetary Science, 2021
Zirconolite is a common Zr-rich accessary mineral in mafic rocks. It is also an ideal U–Pb/Pb–Pb chronometer because it commonly contains high U content (mostly 0.1–10 wt%) and negligible initial Pb.
Nian Wang, Qian Mao, Ting Zhang, Jialong Hao, Yangting Lin   +4 more
doaj   +2 more sources

Look@NanoSIMS – a tool for the analysis of nanoSIMS data in environmental microbiology [PDF]

Environmental Microbiology, 2012
Summary We describe an open‐source freeware programme for high throughput analysis of nanoSIMS (nanometre‐scale secondary ion mass spectrometry) data. The programme implements basic data processing and analytical functions, including display and drift‐corrected accumulation of scanned planes, interactive and semi ...
Polerecky, L., Adam, B., Milucka, J., Musat, N., Vagner, T., Kuypers, M.   +5 more
openaire   +4 more sources

High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis[S] [PDF]

Journal of Lipid Research, 2014
Nanoscale secondary ion MS (NanoSIMS) imaging makes it possible to visualize stable isotope-labeled lipids in cells and tissues at 50 nm lateral resolution. Here we report the use of NanoSIMS imaging to visualize lipids in mouse cells and tissues.
Haibo Jiang, Chris N. Goulbourne, Angelica Tatar, Kirsten Turlo, Daniel Wu, Anne P. Beigneux, Chris R.M. Grovenor, Loren G. Fong, Stephen G. Young   +8 more
doaj   +3 more sources

Automated identification of soil functional components based on NanoSIMS data [PDF]

Ecological Informatics
NanoSIMS technique allows to investigate the micro-spatial organization in complex structures in multiple scientific fields such as material science, cosmochemistry, and biogeochemistry. In soil biogeochemistry applications, NanoSIMS-based approaches aim
Yahan Hu, Johann Maximilian Zollner, Carmen Höschen, Martin Werner, Steffen A. Schweizer   +4 more
doaj   +2 more sources

New highlights of phytolith structure and occluded carbon location: 3-D X-ray microscopy and NanoSIMS results [PDF]

Biogeosciences, 2015
Phytoliths contain occluded organic compounds called phytC. Recently, phytC content, nature, origin, paleoenvironmental meaning and impact in the global C cycle have been the subject of increasing debate.
A. Alexandre, I. Basile-Doelsch, T. Delhaye, D. Borshneck, J. C. Mazur, P. Reyerson, G. M. Santos   +6 more
doaj   +4 more sources

Multimodal Imaging of Chemically Fixed Cells in Preparation for NanoSIMS [PDF]

Analytical Chemistry, 2016
In this work, we have employed time-of-flight secondary ion mass spectrometry (ToF-SIMS) to image chemically fixed adrenal cells prepared for transmission electron microscopy (TEM) and subsequent high-spatial-resolution NanoSIMS imaging. The sample fixation methodology preserves cell morphology, allows analysis in the ultrahigh vacuum environment, and ...
Jelena, Lovrić, Per, Malmberg, Bengt R, Johansson, John S, Fletcher, Andrew G, Ewing   +4 more
openaire   +3 more sources

NanoSIMS applied to the study of foraminifera [PDF]

, 2016
NanoSIMS (Nanoscale Secondary-Ion Mass Spectrometry) is a powerful analytical technique that allows quantitative, subcellular imaging of incorporation and transfer of isotopically labeled compounds and metabolites in biological tissue (Hoppe et al., 2013)
Lekieffre, Charlotte, Geslin, E., Escrig, Stéphane, Jauffrais, Thierry, Spero, Howard, Russell, A., Fehrenbacher, Jennifer, Meibom, Anders   +7 more
openaire   +3 more sources