Results 11 to 20 of about 6,129 (236)
Intracellular Absolute Quantification of Oligonucleotide Therapeutics by NanoSIMS. [PDF]
Analytical Chemistry, 2022 Antisense oligonucleotide (ASO)-based therapeutics hold great potential for the treatment of a variety of diseases. Therefore, a better understanding of cellular delivery, uptake, and trafficking mechanisms of ASOs is highly important for early-stage ...
Cécile Becquart +8 more
semanticscholar +4 more sources
NanoSIMS imaging of lipid absorption by intestinal enterocytes
Journal of Lipid Research, 2022 Absorption of lipids by intestinal enterocytes is crucial for growth and development and is highly relevant to human metabolic diseases. Hence, the molecules and mechanisms for lipid absorption have been studied intensively.
Kai Chen +7 more
doaj +4 more sources
NanoSIMS analysis of arsenic and selenium in cereal grain [PDF]
New Phytologist, 2009 *Cereals are an important source of selenium (Se) to humans and many people have inadequate intakes of this essential trace element. Conversely, arsenic (As) is toxic and may accumulate in rice grain at levels that pose a health risk. Knowledge of the localization of selenium and arsenic within the cereal grain will aid understanding of their ...
Moore, K +8 more
openaire +6 more sources
NanoSIMS and EPMA dating of lunar zirconolite [PDF]
Progress in Earth and Planetary Science, 2021 Zirconolite is a common Zr-rich accessary mineral in mafic rocks. It is also an ideal U–Pb/Pb–Pb chronometer because it commonly contains high U content (mostly 0.1–10 wt%) and negligible initial Pb.
Nian Wang +4 more
doaj +2 more sources
NanoSIMS for biological applications: Current practices and analyses. [PDF]
Biointerphases, 2018 Secondary ion mass spectrometry (SIMS) has become an increasingly utilized tool in biologically relevant studies. Of these, high lateral resolution methodologies using the NanoSIMS 50/50L have been especially powerful within many biological fields over ...
Jamie R. Nuñez +3 more
semanticscholar +3 more sources
Frontiers in Bioengineering and Biotechnology, 2023 In the bioremediation process, coexistence of lead (Pb) and cadmium causes complex toxicity, resulting in the difficulty of bioremediation. This study investigated the physiological responses and bioaccumulation mechanisms of the typical filamentous ...
Shang Pan +11 more
doaj +2 more sources
Frontiers in Chemistry, 2023 Water, in trace amounts, can greatly alter chemical and physical properties of mantle minerals and exert primary control on Earth’s dynamics. Quantifying how water is retained and distributed in Earth’s deep interior is essential to our understanding of ...
Ya-Nan Yang +13 more
doaj +2 more sources
NanoSIMS sulfur isotopic analysis at 100 nm scale by imaging technique
Frontiers in Chemistry, 2023 NanoSIMS has been widely used for in-situ sulfur isotopic analysis (32S and 34S) of micron-sized grains or complex zoning in sulfide in terrestrial and extraterrestrial samples.
Jia-Long Hao +6 more
doaj +2 more sources
International Journal of Molecular Sciences, 2021 The absolute concentration and the compartmentalization of analytes in cells and organelles are crucial parameters in the development of drugs and drug delivery systems, as well as in the fundamental understanding of many cellular processes.
Stefania Rabasco +5 more
semanticscholar +2 more sources
New highlights of phytolith structure and occluded carbon location: 3-D X-ray microscopy and NanoSIMS results [PDF]
Biogeosciences, 2015 Phytoliths contain occluded organic compounds called phytC. Recently, phytC content, nature, origin, paleoenvironmental meaning and impact in the global C cycle have been the subject of increasing debate.
A. Alexandre +6 more
doaj +3 more sources