Results 11 to 20 of about 288,760 (354)
Post-oral sensing of fat increases food intake and attenuates body weight defense
Cell Reports, 2021 Summary: In mammals, changes in weight elicit responses that favor a return to one’s previous weight and promote weight stability. It has been hypothesized that palatable sweet and high-fat foods disturb the defense of body weight, leading to weight gain.
Molly R. Gallop +2 more
doaj +1 more source
Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure
Nature Communications, 2023 β-cell dedifferentiation is a key feature of type 2 diabetes. Here, the authors show evidence of re-differentiation of de-differentiated β-cells and identify ALDH1A3 as a key player in this process, proposing inhibition of ALDH1A3 as a treatment method ...
Jinsook Son +6 more
doaj +1 more source
Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
Experimental and Molecular Medicine, 2023 The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure.
Jinsook Son, Domenico Accili
doaj +1 more source
Assessing the effects of stress on feeding behaviors in laboratory mice
eLife, 2022 Stress often affects eating behaviors, increasing caloric intake in some individuals and decreasing it in others. The determinants of feeding responses to stress are unknown, in part because this issue is rarely studied in rodents. We focused our efforts
Marie Francois +4 more
doaj +1 more source
Journal of Perinatal Education, 2010 A first-time mother, who is also a nurse, tells the story of her drug-free birth at a free-standing birth center.
openaire +2 more sources
Woven Tapestries: Dialogues and Dilemmas in Editing a Diary
European Journal of Life Writing, 2021 Naomi Mitchison (1897-1999) was an established novelist and political campaigner throughout her life. During the Second World War, she kept an extensive daily diary from her home on the Mull of Kintyre in Scotland which she sent in instalments to the ...
Dorothy Sheridan
doaj +1 more source
The polarizable and reprogrammable identity of Kupffer cells in Nonalcoholic Steatohepatitis
Medical Review, 2022 Kupffer cells (KCs) are the resident macrophages of the liver with similar origins to myeloid-derived macrophages. Once differentiated, KCs exhibit distinct cellular machinery capable of longevity and self-renewal, making them a crucial player in ...
Zahr Tarik, Sun Kevin, Qiang Li
doaj +1 more source
Adaptive optics at the WHT [PDF]
, 2001 The WHT is unusually well-placed for exploitation of adaptive-optics (AO) technology. The site seeing is excellent (median 0.7 arcsec), dome seeing is negligible, and preliminary studies indicate that most of the atmospheric seeing originates in a well ...
Benn, C. R.
core +3 more sources
No Is Not Enough: Resisting Trump’s Shock Politics and Winning the World We Need [PDF]
, 2018 Review of Naomi Klein, No Is Not Enough: Resisting Trump’s Shock Politics and Winning the World We Need (Chicago: Haymarket Books, 2017)
van der Linden, Harry
core +2 more sources
Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
Nature Communications, 2016 Diabetes is associated with the de-differentiation of β-cells into a more progenitor-like cell type. Here, the authors identify Aldh3 as a marker of de-differentiating β-cell in animal models of diabetes, and show Aldh3+cells have impaired insulin ...
Ja Young Kim-Muller +6 more
doaj +1 more source