Results 241 to 250 of about 132,409 (312)

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

open access: yesMedComm, Volume 6, Issue 10, October 2025.
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Inamu Rashid Khan   +6 more
wiley   +1 more source

Short bowel syndrome–associated intestinal failure patient experience: A mixed‐method study leveraging an online patient community

open access: yesNutrition in Clinical Practice, Volume 40, Issue 5, Page 1115-1124, October 2025.
Abstract Background Patients with short bowel syndrome–associated intestinal failure (SBS‐IF) require complex, personalized, and multidisciplinary care; however, there are disparities in access. This study measured the impact of unmet needs and treatment burden among patients and their caregivers.
Brian Po‐Han Chen   +6 more
wiley   +1 more source

Performance of Large Language Models in Nursing Examinations: Comparative Analysis of ChatGPT‐3.5, ChatGPT‐4 and iFLYTEK Spark in China

open access: yesNursing Open, Volume 12, Issue 10, October 2025.
ABSTRACT Background While large language models (LLMs) have been widely utilised in nursing education, their performance in Chinese nursing examinations remains unexplored, particularly in the context of ChatGPT‐3.5, ChatGPT‐4 and iFLYTEK Spark. Purpose This study assessed the performance of ChatGPT‐3.5, ChatGPT‐4 and iFLYTEK Spark on the 2022 China ...
Peifang Li   +3 more
wiley   +1 more source

Identifying Pediatric Drug Safety Knowledge Gaps: An Integrated Approach Leveraging Real‐World Data, a Biomedical Knowledge Base, and Postmarketing Surveillance Data

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 10, Page 667-676, October 2025.
ABSTRACT Background Drug safety has historically been understudied in pediatric populations, rendering them “therapeutic orphans.” Pediatric drug indications and dosages are often inferred by extrapolating safety, efficacy, and dosing data from adult studies, leading to widespread off‐label use.
Saurabh Rahurkar   +8 more
wiley   +1 more source

A DOUBLE-BLIND STUDY of TACARYL??* as a narcotic potentiator when used for preliminary medication???

open access: bronze, 1962
William H. L. Dornette   +3 more
openalex   +1 more source

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