Results 101 to 110 of about 3,767,146 (252)

Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Aβ burden in early Alzheimer’s disease models

open access: yesPharmacological Research
Aberrant energy metabolism in the brain is a common pathological feature in the preclinical Alzheimer's Disease (AD). Recent studies have reported the early elevations of glycolysis-involved enzymes in AD brain and cerebrospinal fluid according to a ...
Xiu Yang   +7 more
doaj  

The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning

open access: yesFrontiers in Immunology
IntroductionFear memory formation has been implicated in fear- and stress-related psychiatric disorders, including post-traumatic stress disorder (PTSD) and phobias.
Le-le Zhang   +15 more
doaj   +1 more source

A Two-Layer Mathematical Modelling of Drug Delivery to Biological Tissues [PDF]

open access: yesarXiv, 2016
Local drug delivery has received much recognition in recent years, yet it is still unpredictable how drug efficacy depends on physicochemical properties and delivery kinetics. The purpose of the current study is to provide a useful mathematical model for drug release from a drug delivery device and consecutive drug transport in biological tissue ...
arxiv  

Managing dual disorders: a statement by the Informal Scientific Network, UN Commission on Narcotic Drugs. [PDF]

open access: yesWorld Psychiatry, 2020
Volkow ND   +9 more
europepmc   +1 more source

NAT10 inhibition alleviates astrocyte autophagy by impeding ac4C acetylation of Timp1 mRNA in ischemic stroke

open access: yesActa Pharmaceutica Sinica B
Although a single nucleotide polymorphism for N-acetyltransferase 10 (NAT10) has been identified in patients with early-onset stroke, the role of NAT10 in ischemic injury and the related underlying mechanisms remains elusive.
Li Yang   +15 more
doaj  

Inhibition of gastric emptying and drug absorption by narcotic analgesics. [PDF]

open access: bronze, 1975
W.S. Nimmo   +4 more
openalex   +1 more source

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