Results 161 to 170 of about 210,976 (360)

Inpatient Opioid Use in Head and Neck Microvascular Free Flap Reconstruction

open access: yesOtolaryngology–Head and Neck Surgery, Volume 174, Issue 5, Page 1230-1235, May 2026.
Abstract Objectives The primary objective is to determine whether patients undergoing osseous microvascular free flap reconstruction of head and neck defects have higher inpatient pain requirements than those undergoing nonosseous reconstruction. Secondary aims include evaluating the impact of a multimodal analgesia (MMA) protocol and COVID‐19 visitor ...
Patricia Timothee   +8 more
wiley   +1 more source

The Analgesic Effect of Extended Reality (XR) on Acute and Postoperative Pain in Children: A Systematic Review and Meta‐Analysis

open access: yesPediatric Anesthesia, Volume 36, Issue 5, Page 479-490, May 2026.
ABSTRACT Background Acute and postoperative pain in children is often undertreated, with effects on patient comfort and postoperative recovery. Extended reality (XR) interventions offer non‐pharmacological pain management by distracting patients from discomfort.
Louise Meulenkamp‐Yilmaz   +5 more
wiley   +1 more source

The Structure of the Chemotype Determining Locus in Cannabis sativa

open access: yesPlant Direct, Volume 10, Issue 5, May 2026.
ABSTRACT The chemical phenotype (chemotype) of Cannabis sativa is defined by the ratio of cannabidiolic acid (CBDA) to Δ9‐tetrahydrocannabinolic acid (THCA). Although the Mendelian segregation of these traits suggests a single‐locus biallelic system, recent sequencing and phylogenetic evidence indicate they are encoded by two distinct, tightly linked ...
Keith Allen   +2 more
wiley   +1 more source

Comorbid Alzheimer's Disease and Type 2 Diabetes Microbiota Shape Age‐Associated Gut–Brain Axis Profiles

open access: yesAging Cell, Volume 25, Issue 5, May 2026.
Fecal microbiota transplantation from elderly donors with Alzheimer's disease, type 2 diabetes, or both conditions into antibiotic‐treated mice revealed that comorbid microbiota produce the most severe dysbiosis and strongest suppression of hippocampal neurotrophic gene expression.
Alessandro Atzeni   +16 more
wiley   +1 more source

Evaluating the Impact of Putative Metformin Targets on Cancer Outcomes: A Drug‐Target Mendelian Randomization Study

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4091-4099, May 2026.
ABSTRACT Aims Observational studies show metformin use associated with lower cancer risk, although experimental evidence is inconsistent. To provide genetic validation for repositioning of metformin in cancer prevention, we assessed genetically proxied effects of putative metformin targets on cancer outcomes using a drug‐target Mendelian randomization (
Xingyu Shen   +7 more
wiley   +1 more source

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