Results 21 to 30 of about 63,908 (210)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

The structure of the lithosphere, tectonics and evolution of the Scythian Plate and adjacent structures in the section of the Bs05-22 profile (according to 2-d density modeling)

Геологія і корисні копалини Світового океану, 2020
A density model was built along the Bs05-22 profile, which made it possible to identify individual blocks with different crustal parameters. The consolidated crust of the East European Platform (EEP) has a “key” structure.
M. Kozlenko, Yu. Kozlenko
doaj   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Monotonicity of solutions for parabolic equations involving nonlocal Monge-Ampère operator

Advances in Nonlinear Analysis
In this article, we consider the parabolic equations with nonlocal Monge-Ampère operators ∂u∂t(x,t)−Dsθu(x,t)=f(u(x,t)),(x,t)∈R+n×R.\frac{\partial u}{\partial t}\left(x,t)-{D}_{s}^{\theta }u\left(x,t)=f\left(u\left(x,t)),\hspace{1.0em}\left(x,t)\in ...
Du Guangwei, Wang Xinjing
doaj   +1 more source

Elinvar Materials: Recent Progress and Challenges

Advanced Engineering Materials, EarlyView.
Elinvar materials, exhibiting temperature‐invariant elastic modulus, are critical for precision instruments and emerging technologies. This article reviews recent progress in the field, with a focus on the anomalous thermoelastic behavior observed in key material systems.
Wenjie Li, Yang Ren
wiley   +1 more source

Threats to salmon and endangered fish species in Tysa river basin within trans Carpathian region (review)

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Гжицького. Серія: Сільськогосподарські науки, 2019
Establish ways of creating, thoroughly investigate the threats and their level of salmon and endangered fish species Tysa River Basin within Zakarpattia region.
V. P. Terpay
doaj   +1 more source

3D‐Printed Giant Magnetoresistive (GMR) Sensors Based on Self Compliant Springs

Advanced Engineering Materials, EarlyView.
This work explores 3D‐printed GMR sensors utilizing self‐compliant spring structures and conductive PLA composites. By optimizing arm width, we achieved high piezoresistive (0.34%/mm) and magnetoresistive (0.77%/mT) sensitivities. Demonstrated through Bluetooth‐integrated pressure and magnetic position sensing, these full printed low‐cost, customizable
Josu Fernández Maestu, Nelson Pereira, Javier Vicente, Carmen Rial Tubio, Senentxu Lanceros‐Méndez   +4 more
wiley   +1 more source

Radial symmetry, monotonicity and Liouville theorem for Marchaud fractional parabolic equations with the nonlocal Bellman operator

Advanced Nonlinear Studies
In this article, we focus on studying space-time fractional parabolic equations with the nonlocal Bellman operator and the Marchaud fractional derivative. To address the difficulty caused by the space-time non-locality of operator ∂tα−Fs ${\partial }_{t}^
Liu Mengru, Zhang Lihong, Wang Guotao
doaj   +1 more source