Results 271 to 280 of about 2,438,339 (329)

A Randomized, Placebo‐Controlled Trial of Hydroxychloroquine in Incomplete Lupus

Arthritis &Rheumatology, EarlyView.
Objective Patients with features of systemic lupus erythematosus (SLE) who do not fulfill classification criteria can be designated as incomplete lupus erythematosus (ILE). This condition includes individuals with a high risk of progression to SLE. Treatment of ILE may reduce symptoms, severity, and incidence of SLE.
Nancy J. Olsen, Duanping Liao, Judith A. James, Joel M. Guthridge, Cristina Arriens, Diane Kamen, Mariko Ishimori, Daniel J. Wallace, Christopher Striebich, Sonali Narain, Benjamin F. Chong, Fan He, Eric W. Schaefer, Vernon M. Chinchilli, David R. Karp   +14 more
wiley   +1 more source

The Effect of Benralizumab and Mepolizumab on Use of Oral Glucocorticoids in Patients With Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Objective The phase 3 MANDARA study demonstrated noninferiority of benralizumab versus mepolizumab for remission in patients with eosinophilic granulomatosis with polyangiitis (EGPA). More benralizumab‐treated patients achieved complete withdrawal of oral glucocorticoids (OGCs).
Parameswaran K. Nair, Bernhard Hellmich, Arnaud Bourdin, David R. W. Jayne, Florence Roufosse, Nader Khalidi, Lena Börjesson Sjö, Ying Fan, Christopher McCrae, Sofia Necander, Eva Rodríguez‐Suárez, Anat Shavit, Claire Walton, Peter A. Merkel, Michael E. Wechsler   +14 more
wiley   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Investigating the efficacy of nasal administration for delivering magnetic nanoparticles into the brain for magnetic particle imaging

Satoshi Seino, Hiroto Ikehata, Mizuki Tanabe, Tomohiro Umeda, Takami Tomiyama, Akiko Tanaka, Tomoyuki Furubayashi, Toshiyasu Sakane, Toshihiko Kiwa, Masaomi Washino, Kota Nomura, Shun Tonooka, Akihiro Izawa, Yuki Okumura, Takashi Nakagawa   +14 more
openalex   +1 more source

Interleukin (IL)‐5, Eosinophils and IL‐5 Pathway Inhibitors in Eosinophilic Granulomatosis with Polyangiitis.

Arthritis &Rheumatology, Accepted Article.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Development of polysaccharide nanoparticles for the nasal administration of drugs for the treatment of neurodegenerative diseases

, 2019
Adryana Clementino
openalex   +1 more source

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Nasal Formulations for Drug Administration and Characterization of Nasal Preparations in Drug Delivery

Therapeutic Delivery, 2020
This special report gives an insight in the rationale of utilizing the nasal cavity for drug administration and the formulation as well as characterization of nasal preparations. As the nose is an easy-to-access, noninvasive and versatile location for absorption, this route of delivery will play an increasingly important role in future drug product ...
R. Scherließ
openaire   +3 more sources

Performance and toxicity of different absorption enhancers used in the preparation of Poloxamer thermosensitive in situ gels for ketamine nasal administration

Drug Development and Industrial Pharmacy, 2020
The purpose of this study was to investigate the nasal absorption rate and nasal mucosal toxicity of thermosensitive ketamine in situ gels containing various absorption enhancers. The optimal composition ratio for the gel matrix was determined to be 17.2%
Yunjie Xia, Longnian Li, Xiaowu Huang, Zengming Wang, Hui Zhang, Jing Gao, Yimeng Du, Wen Chen, Aiping Zheng   +8 more
semanticscholar   +1 more source

Progesterone administration by nasal spray

Fertility and Sterility, 1991
The bioavailability and the clinical usefulness of the P administered by nasal spray were investigated. Ten healthy menopausal women received an IN spray administration (4 doses of an oleic P solution 20 mg/mL, corresponding to nearly 11.2 mg of P) and the circulating P levels were calculated.
CICINELLI, Ettore, RAGNO G, CAGNAZZO I, FANELLI F, VETUSCHI C, SCHONAUER S.   +5 more
openaire   +2 more sources

Mucoadhesive microspheres for nasal administration of cyclodextrins

Journal of Drug Targeting, 2009
The aim of this study was to examine the in vitro capacity of cyclodextrins to interfere on the beta-amyloid fibril formation; then, mucoadhesive microspheres containing cyclodextrins were prepared and characterised as nasal delivery system for brain targeting.
Gavini E, Rassu G, Haukvik T, LANNI, CRISTINA, RACCHI, MARCO, Giunchedi P.   +5 more
openaire   +3 more sources