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Nasal Administration of Vaccines
2014Nasal administration of vaccines is an interesting route of delivery as it targets one of the mucosal surfaces naturally being in contact with many airborne pathogens. For this reason, the nasal mucosa has a dense network of immunocompetent cells which can be utilised for vaccination.
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Mucoadhesive chitosan microspheres of carvedilol for nasal administration
Journal of Drug Targeting, 2010The aim of the present study was to develop and characterize chitosan mucoadhesive microspheres of carvedilol (CRV) for nasal delivery to improve bioavailability for treatment of hypertension and angina pectoris. The microspheres were prepared by emulsification-cross-linking method and evaluated for size, shape, entrapment efficiency (EE), in vitro ...
Sanjay, Patil +4 more
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Nasal Administration: A Tool for Tomorrow's Systemic Administration of Drugs
Drug Development and Industrial Pharmacy, 1993AbstractBy its anatomy and physiology, due to the great amount of air treated there, the nasal route represents a very interesting possibility for the administration of products degraded in the gastro-intestinal tract or inhibited by the first hepatic pass.
Dominique Duchěne, Gilles Ponchel
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Nasal Administration of Granisetron to Rats
Journal of Korean Pharmaceutical Sciences, 2006Granisetron is a selective 5-HT3 receptor antagonist that is used therapeutically for the prevention of vomiting and nausea associated with emetogenic cancer chemotherapy. Although this drug is commercially available for intravenous and oral dosage, there is a need for intranasal delivery formulations in specific patient populations in which the use of
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Therapeutic Delivery, 2020
This special report gives an insight in the rationale of utilizing the nasal cavity for drug administration and the formulation as well as characterization of nasal preparations. As the nose is an easy-to-access, noninvasive and versatile location for absorption, this route of delivery will play an increasingly important role in future drug product ...
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This special report gives an insight in the rationale of utilizing the nasal cavity for drug administration and the formulation as well as characterization of nasal preparations. As the nose is an easy-to-access, noninvasive and versatile location for absorption, this route of delivery will play an increasingly important role in future drug product ...
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Nasal administration of naloxone for detection of opiate dependence
Journal of Psychiatric Research, 1992In clinical trials, nasally applied naloxone was used to identify opiate dependence in humans for the first time. Withdrawal distress was recorded, and pupillary response, pulse rate and blood pressure measured. A significant increase in withdrawal distress and pupillary dilation was observed after nasal administration of 1mg (1mg/400 microliters ...
N, Loimer, P, Hofmann, H R, Chaudhry
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Nasal mucosa inflammation induced by oxygen administration in humans
Acta Anaesthesiologica Scandinavica, 1997Background: The effect of oxygen toxicity in human airways is still poorly documented. We prospectively evaluated the inflammatory reaction induced by nasal oxygen exposure in an experimental setting.Methods: Healthy subjects without nasal symptoms were exposed to high FIO2 during 5 h. Oxygen was delivered from a tank at a flow of 41/min to one nostril
G, Capellier +7 more
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[Stomach rupture after nasal oxygen administration].
Annales francaises d'anesthesie et de reanimation, 2004We report a case of a spontaneous rupture of a normal stomach after therapeutic oxygen administration. In this case, early treatment precluded the need for a laparotomy. This rare complication highlights the importance of the right positioning of a nasal catheter and leads us to question its role compared to other means of oxygen delivery (nasal ...
M, Adam +4 more
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Desmopressin Dry Powder for Nasal Administration
2007Purpose: To produce a dry powder formulation for the antidiuretic cyclic peptide desmopressin acetate (DDAVP) as an alternative to conventional liquid nasal formulations.
COLOMBO, Gaia +6 more
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