Results 1 to 10 of about 1,950,111 (204)

Intranasal administration of dantrolene increased brain concentration and duration.

PLoS ONE, 2020
Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang, Yun Shi, Shuchun Yu, Yan Wang, Qingcheng Meng, Ge Liang, Maryellen F Eckenhoff, Huafeng Wei   +7 more
doaj   +2 more sources

Electrocardiogram Assessment in Chough (Pyrrhocorax pyrrhocorax) Following Intranasal Administration of Anesthetics [PDF]

Iranian Journal of Veterinary Surgery, 2017
Objective- The objective of the present study was to define electrocardiographic data following intranasal administration of diazepam, midazolam and xylazine with or without Ketamine in Chough.Design- To determine the heart effects of anesthetics in ...
Majid Taati, Abbas Raisi
doaj   +1 more source

Clinical and pharmacokinetics overview of intranasal administration of fentanyl

Heliyon, 2023
Due to the presence of large surfaces and high blood supply, drug delivery through the nasal route of administration is the appropriate route to administrate drugs with rapid onsets of action. Bypassing first-pass metabolism can increase drug bioavailability.
Samaneh Nakhaee, Farhad Saeedi, Omid Mehrpour   +2 more
openaire   +3 more sources

The pharmacokinetics of intranasal droperidol in volunteers characterised via population modelling

SAGE Open Medicine, 2018
Background: Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol.
Isabelle Cooper, Cornelia B Landersdorfer, Ashley Gordon St John, Andis Graudins   +3 more
doaj   +1 more source

Development and evaluation of vinpocetine inclusion complex for brain targeting

Asian Journal of Pharmaceutical Sciences, 2015
The objective of this paper is to prepare vinpocetine (VIN) inclusion complex and evaluate its brain targeting effect after intranasal administration. In the present study, VIN inclusion complex was prepared in order to increase its solubility. Stability
Jiaojiao Ding, Jinfeng Li, Shirui Mao
doaj   +1 more source

Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients

Pharmaceutics, 2022
The histamine-1 receptor antagonist azelastine was recently found to impact SARS-CoV-2 viral kinetics in a Phase 2 clinical trial (CARVIN). Thus, we investigated the relationship between intranasal azelastine administrations and viral load, as well as ...
Christiane Dings, Peter Meiser, Frank Holzer, Michael Flegel, Dominik Selzer, Eszter Nagy, Ralph Mösges, Jens Peter Klussmann, Thorsten Lehr   +8 more
doaj   +1 more source

Nose-to-brain delivery of donepezil within a small dose improves bioavailability and efficacy for Alzheimer’s disease treatment

Asian Journal of Pharmaceutical Sciences
Oral administration of donepezil (Don) is the first-line medication for Alzheimer’s disease (AD); however, the dysphagia of elderly patients and severe gastrointestinal side effects substantially restrict administration compliance.
Gang Wang, Xuezhe Duan, Defang Ouyang, Jianping Zhou, Huaqing Zhang, Yang Ding   +5 more
doaj   +1 more source

Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature

International Journal of Medical Students, 2016
A lack of effective treatment for patients with treatment-resistant depression (TRD) has led to the evaluation of ketamine, an N-methyl- D-aspartate receptor antagonist.
Patrick Arthur Twohig, Vaughn Huckfeldt
doaj   +1 more source

Study of embryotoxic effects of intranasally administred desloratadine on laboratory animals. [PDF]

Medičnì Perspektivi, 2017
The study was conducted to detect possible changes in embryogenesis and negative effects of third generation antihistamine – desloratadine – after intranasal administration of 1.3 mg/m3 and 13.0 mg/m3 of the substance to laboratory animals during their ...
Т. А. Alekhina, V. А. Turkina, О. І. Grushka   +2 more
doaj   +2 more sources

Pharmacokinetic Modeling of the “Nose-to-Brain” Pathway as Demonstrated by Intranasal Administration of Cannabidiol-Loaded Nanoparticles

Pharmaceuticals
Background/Objectives: Cannabidiol is a non-psychoactive substance that possesses properties suitable for the treatment of several disorders related to the central nervous system.
Ilya Eydelman, Shimon Ben-Shabat, Amnon C. Sintov   +2 more
doaj   +1 more source