Results 1 to 10 of about 59,442 (261)

Pharmacokinetic Modeling of the “Nose-to-Brain” Pathway as Demonstrated by Intranasal Administration of Cannabidiol-Loaded Nanoparticles [PDF]

Pharmaceuticals
Background/Objectives: Cannabidiol is a non-psychoactive substance that possesses properties suitable for the treatment of several disorders related to the central nervous system.
Ilya Eydelman, Shimon Ben-Shabat, Amnon C. Sintov   +2 more
doaj   +2 more sources

Cardiac Safety of Intranasal Chlorpheniramine: An Exposure-Based Risk Assessment [PDF]

Pharmaceuticals
Background: H1-antihistamines are widely used for allergic and upper respiratory conditions; however, several agents included in this class have been associated with cardiac electrophysiological adverse effects, including QT interval prolongation and ...
César Alas-Pineda, Dennis J. Pavón-Varela, Kristhel Gaitán-Zambrano, Gustavo Ferrer   +3 more
doaj   +2 more sources

Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications

Pharmaceutics, 2023
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Jesus Vicente de Julian-Ortiz, Amparo Nacher, Raquel Taléns-Visconti   +2 more
exaly   +3 more sources

Nose-to-brain delivery of donepezil within a small dose improves bioavailability and efficacy for Alzheimer’s disease treatment [PDF]

Asian Journal of Pharmaceutical Sciences
Oral administration of donepezil (Don) is the first-line medication for Alzheimer’s disease (AD); however, the dysphagia of elderly patients and severe gastrointestinal side effects substantially restrict administration compliance.
Gang Wang, Xuezhe Duan, Defang Ouyang, Jianping Zhou, Huaqing Zhang, Yang Ding   +5 more
doaj   +2 more sources

Bioavailability of dexmedetomidine after intranasal administration

European Journal of Clinical Pharmacology, 2011
The aim of this proof-of-concept study was to characterize the pharmacokinetics and pharmacodynamics of intranasal dexmedetomidine compared with its intravenous administration in a small number of healthy volunteers.Single doses of 84 μg of dexmedetomidine were given once intravenously and once intranasally to seven healthy men.
Mika Scheinin, Klaus Tapio Olkkola, Tuula Manner   +2 more
exaly   +6 more sources

Intranasal creatine administration increases brain creatine level and improves Barnes maze performance in rats

Brain Research Bulletin, 2023
While skeletal muscle creatine levels can be enhanced by exogenous creatine supplementation, the elevation of brain creatine levels with oral creatine administration remains a challenge due to a lack of effective transportation of creatine through the ...
Kaiqing Chen, Xiaoping Hu
doaj   +1 more source

Utility of a Novel Micro-Spraying Device for Intranasal Administration of Drug Solutions to Mice

Pharmaceutics, 2023
Intranasal administration has attracted attention as a means of delivering drugs because it bypasses the blood–brain barrier. However, conventional intranasal administration of drug solutions to mice using the micropipette method (MP method) is ...
Naoto Suzuki, Hiroaki Tanigawa, Taiki Nagatomo, Hiroko Miyagishi, Takanori Kanazawa, Toyofumi Suzuki, Yasuhiro Kosuge   +6 more
doaj   +1 more source

Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers

Pain Research and Management, 2021
Background. For more than 60 years, the synthetic opioid fentanyl has been widely used in anaesthesia and analgesia. While the intravenous formulation is primarily used for general anaesthesia and intensive care settings, the drug’s high lipophilic ...
S. Nardi-Hiebl, J. W. Ndieyira, Y. Al Enzi, W. Al Akkad, T. Koch, G. Geldner, C. Reyher, L. H. J. Eberhart   +7 more
doaj   +1 more source

Intranasal administration of collagenase develops cerebral microbleeds and vascular dementia in mice: In vivo pilot study

Brain Hemorrhages, 2023
Objective: To establish a new animal model of lobar cerebral microbleeds (CMBs), we examined whether intranasal administration of collagenase induced CMBs in young mice which did not have hypertensive pathologic features. Methods: We used thirty-two male
Kenyu Hayashi, Prativa Sherchan, John H. Zhang, Yu Hasegawa   +3 more
doaj   +1 more source

Intranasal Vaccination With Recombinant Antigen-FLIPr Fusion Protein Alone Induces Long-Lasting Systemic Antibody Responses and Broad T Cell Responses

Frontiers in Immunology, 2021
A simple formulation is urgently needed for mucosal vaccine development. We employed formyl peptide receptor-like 1 inhibitory protein (FLIPr), an FcγR antagonist secreted by Staphylococcus aureus, as a vector to target ovalbumin (OVA) to dendritic cells
Ming-Shu Hsieh, Chia-Wei Hsu, Ling-Ling Tu, Kit Man Chai, Li-Lu Yu, Chiao-Chieh Wu, Mei-Yu Chen, Chen-Yi Chiang, Shih-Jen Liu, Shih-Jen Liu, Shih-Jen Liu, Ching-Len Liao, Hsin-Wei Chen, Hsin-Wei Chen, Hsin-Wei Chen   +14 more
doaj   +1 more source