Results 1 to 10 of about 32,558 (212)

Intranasal delivery of imaging agents to the brain [PDF]

Theranostics
The potential of intranasal administered imaging agents to altogether bypass the blood-brain barrier offers a promising non-invasive approach for delivery directly to the brain. This review provides a comprehensive analysis of the advancements and challenges of delivering neuroimaging agents to the brain by way of the intranasal route, focusing on the ...
Almahmoud, Abdallah, Parekh, Harendra S., Paterson, Brett M., Tupally, Karnaker Reddy, Vegh, Viktor   +4 more
openaire   +5 more sources

Strategies for intranasal delivery of vaccines [PDF]

Drug Delivery and Translational Research, 2012
The vast majority of human pathogens colonize and invade at the mucosal surfaces. Preventing infection at these sites via mucosally active vaccines is a promising and rational approach for vaccine development. However, it is only recently that the stimulation of local immunity at the mucosal surfaces has become a primary objective in addition to ...
Zaman, Mehfuz, Chandrudu, Saranya, Toth, Istvan   +2 more
openaire   +5 more sources

Intranasal Delivery of Morphine

The Journal of Pharmacology and Experimental Therapeutics, 2002
Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a highly increased absorption with a 5 ...
L, Illum, P, Watts, A N, Fisher, M, Hinchcliffe, H, Norbury, I, Jabbal-Gill, R, Nankervis, S S, Davis   +7 more
openaire   +2 more sources

A Promising Drug Delivery: Intranasal Drug Delivery System

International Journal of Pharmaceutical Sciences Review and Research, 2021
Pneumonic medication conveyance has acquired gigantic logical interest as of late and has advanced inside the setting of treatment for lung infections. Lung is an appealing climate for bio particles, which are exceptionally presented to enzymatic debasement in the gastrointestinal parcel just as hepatic corruption.
M. Srinivas, Y. Kalyani, J. V. C. Sharma
openaire   +1 more source

Intranasal delivery of cells to the brain

European Journal of Cell Biology, 2009
The safety and efficacy of cell-based therapies for neurodegenerative diseases depends on the mode of cell administration. We hypothesized that intranasally administered cells could bypass the blood-brain barrier by migrating from the nasal mucosa through the cribriform plate along the olfactory neural pathway into the brain and cerebrospinal fluid ...
Lusine, Danielyan, Richard, Schäfer, Andreas, von Ameln-Mayerhofer, Marine, Buadze, Julia, Geisler, Tim, Klopfer, Ute, Burkhardt, Barbara, Proksch, Stephan, Verleysdonk, Miriam, Ayturan, Gayane H, Buniatian, Christoph H, Gleiter, William H, Frey   +12 more
openaire   +2 more sources

Intranasal delivery of Thyroid hormones in MCT8 deficiency [PDF]

PLOS ONE, 2020
All relevant data are within the paper.
Grijota-Martínez, Carmen, Bárez-López, Soledad, Ausó, Eva, Refetoff, Samuel, Frey II, William H., Guadaño-Ferraz, Ana   +5 more
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Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery [PDF]

Frontiers in Chemistry, 2020
في السنوات الأخيرة، أثبتت المواد الهجينة النانوية المتقدمة التي تمت معالجتها كمستحضرات صيدلانية أنها مفيدة للغاية. التريبتان، مثل السوماتريبتان داخل الأنف المتاح تجاريًا (SMT)، هي أدوية تستخدم في علاج أعراض الصداع النصفي المؤلمة. ومع ذلك، فإن فعالية SMT محدودة بسبب أليفتها العالية للماء وضعف التصاق الغشاء المخاطي.
Lígia Nunes de Morais Ribeiro, Gustavo Henrique Rodrigues da Silva, Verônica Muniz Couto, Simone R. Castro, Márcia Cristina Breitkreitz, Carolina Martínez, Daniela E. Igartúa, María Jimena Prieto, Eneida de Paula   +8 more
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Intranasal Delivery of Antiviral siRNA [PDF]

, 2011
Intranasal administration of synthetic siRNA is an effective modality of RNAi delivery for the prevention and therapy of respiratory diseases, including pulmonary infections. Vehicles used for nasal siRNA delivery include established as well as novel reagents, many of which have been recently optimized.
openaire   +2 more sources

Intranasal drug delivery by spray and drops

Journal of Pharmacy and Pharmacology, 1985
Abstract A solution of 99m Tc-labelled human serum albumin was administered into the nose as a spray and as one or three drops. The patterns of deposition and the rates of clearance in normal subjects were monitored by gamma scintigraphy. The spray was deposited mainly in the atrium, and cleared slowly into the pharynx.
J G, Hardy, S W, Lee, C G, Wilson
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Chitosan Nanoparticles for Intranasal Drug Delivery

Pharmaceutics
This manuscript explores the use of nanostructured chitosan for intranasal drug delivery, targeting improved therapeutic outcomes in neurodegenerative diseases, psychiatric care, pain management, vaccination, and diabetes treatment. Chitosan nanoparticles are shown to enhance brain delivery, improve bioavailability, and minimize systemic side effects ...
Hossein Omidian, Erma J. Gill, Sumana Dey Chowdhury, Luigi X. Cubeddu   +3 more
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