Results 1 to 10 of about 31,838 (257)

Intranasal delivery systems for traumatic brain injury: Advancements and perspectives [PDF]

Journal of Tissue Engineering
Traumatic brain injury (TBI) is a major cause of mortality and morbidity, commonly leading to long-term impairments in cognition, sensorimotor function, and personality. While neuroprotective drugs have demonstrated some efficacy in vitro cultures and in
Shin Hyuk Yoo, Soon Chul Heo, Jun Sang Bae, Jun Hee Lee, Jonathan C. Knowles, Hae-Won Kim   +5 more
doaj   +2 more sources

Intranasal delivery of bryostatin-1 using surface charge-engineered lipid nanoparticles to modulate mucosal defense for allergic rhinitis treatment [PDF]

Scientific Reports
Allergic rhinitis (AR), driven by immune imbalance and excessive IgE production, manifests with symptoms that significantly impair the patient’s quality of life. Current therapies mainly provide symptomatic relief without correcting the underlying immune
Jiayue Li, Naoki Morita, Risako Miura, Yu Kimura, Reiko Shinkura, Teruyuki Kondo   +5 more
doaj   +2 more sources

Intranasal delivery of rotigotine to the brain for treating Parkinson’s disease [PDF]

Fundamental Research
: The development of sustainable and non-invasive method for delivering drugs to the brain is crucial for the effective treatment of Parkinson’s disease (PD).
Dandan Kou, Keyang Xu, Jiahui Yin, Ning Wang, Ruru Zhang, Jianfeng Zeng, Mingyuan Gao   +6 more
doaj   +2 more sources

CSF and blood oxytocin concentration changes following intranasal delivery in macaque. [PDF]

PLoS ONE, 2014
Oxytocin (OT) in the central nervous system (CNS) influences social cognition and behavior, making it a candidate for treating clinical disorders such as schizophrenia and autism.
Olga Dal Monte, Pamela L Noble, Janita Turchi, Alex Cummins, Bruno B Averbeck   +4 more
doaj   +3 more sources

Optimization of formulation for enhanced intranasal delivery of insulin with translationally controlled tumor protein-derived protein transduction domain

Drug Delivery, 2019
Intranasal delivery of insulin is an alternative approach to treat diabetes, as it enables higher patient compliance than conventional therapy with subcutaneously injected insulin. However, the use of intranasal delivery of insulin is limited for insulin’
Hae-Duck Bae, Ji-Sun Lee, Haejun Pyun, Moonhee Kim, Kyunglim Lee   +4 more
doaj   +2 more sources

Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants [PDF]

Signal Transduction and Targeted Therapy
The mucosal immune response plays a crucial role in the prevention of respiratory viruses. Given the risk of recurrent SARS-CoV-2 infections in the population, the rapid development of next-generation intranasal COVID-19 vaccines with high safety and ...
Hong Lei, Weiqi Hong, Jingyun Yang, Cai He, Yanan Zhou, Yu Zhang, Aqu Alu, Jie Shi, Jian Liu, Furong qin, Danyi Ao, Xiya Huang, Zimin Chen, Hao Yang, Yun Yang, Wenhai Yu, Cong Tang, Junbin Wang, Bai Li, Qing Huang, Hongbo Hu, Wei Cheng, Haohao Dong, Jian Lei, Lu Chen, Xikun Zhou, Jiong Li, Li Yang, Zhenling Wang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Guangwen Lu, Qiangming Sun, Youchun Wang, Shuaiyao Lu, Xiawei Wei   +38 more
doaj   +2 more sources

Rapid and Widespread Distribution of Intranasal Small Extracellular Vesicles Derived from Mesenchymal Stem Cells throughout the Brain Potentially via the Perivascular Pathway

Pharmaceutics, 2023
Intranasal administration is a promising strategy to enhance the delivery of the sEVsomes-based drug delivery system to the central nervous system (CNS).
Weiwei Shen, Tongyao You, Wenqing Xu, Yanan Xie, Yingzhe Wang, Mei Cui   +5 more
doaj   +1 more source

Differential Biodistribution of Adenoviral-Vectored Vaccine Following Intranasal and Endotracheal Deliveries Leads to Different Immune Outcomes

Frontiers in Immunology, 2022
Infectious diseases of the respiratory tract are one of the top causes of global morbidity and mortality with lower respiratory tract infections being the fourth leading cause of death.
Vidthiya Jeyanathan, Vidthiya Jeyanathan, Sam Afkhami, Sam Afkhami, Michael R. D’Agostino, Michael R. D’Agostino, Anna Zganiacz, Anna Zganiacz, Xueya Feng, Xueya Feng, Matthew S. Miller, Matthew S. Miller, Mangalakumari Jeyanathan, Mangalakumari Jeyanathan, Michael R. Thompson, Zhou Xing, Zhou Xing   +16 more
doaj   +1 more source

Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System

Pharmaceutics, 2022
The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB.
Oxana Semyachkina-Glushkovskaya, Alexander Shirokov, Inna Blokhina, Valeria Telnova, Elena Vodovozova, Anna Alekseeva, Ivan Boldyrev, Ivan Fedosov, Alexander Dubrovsky, Alexandr Khorovodov, Andrey Terskov, Arina Evsukova, Daria Elovenko, Viktoria Adushkina, Maria Tzoy, Ilana Agranovich, Jürgen Kurths, Edik Rafailov   +17 more
doaj   +1 more source

The hidden obstacles to intranasal insulin delivery: A narrative review

Journal of Diabetology, 2023
A large number of people are suffering with one or the other type of diabetes around the globe. Insulin has proven to be beneficial for the treatment of both types of diabetes.
Ujjawal Rawat, Ambika Choudhary, Piyush Mittal, Anurag Verma   +3 more
doaj   +1 more source