Results 31 to 40 of about 57,259 (320)

Synthesis of an insulin-loaded mucoadhesive nanoparticle designed for intranasal administration: focus on new diffusion media

Frontiers in Pharmacology, 2023
Intranasal administration is a drug delivery approach to provide a non-invasive pharmacological response in the central nervous system with relatively small peripheral side effects. To improve the residence time of intranasal drug delivery systems in the
Tahereh Jamshidnejad-Tosaramandani, Tahereh Jamshidnejad-Tosaramandani, Tahereh Jamshidnejad-Tosaramandani, Soheila Kashanian, Soheila Kashanian, Isaac Karimi, Helgi B. Schiöth   +6 more
doaj   +1 more source

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]

, 2017
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria, Di Marzio, Luisa, Hanieh, PATRIZIA NADIA, Marianecci, Carlotta, Paolino, Donatella, Rinaldi, Federica   +5 more
core   +1 more source

A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries [PDF]

, 2020
Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche
A Buffo, A Kamezaki, A Torroglosa, AC Newton, AC Rice, AX Wu-Zhang, BT Susarla, C Kilkenny, C Romero-Grimaldi, CP Blobel, DC Lee, DR Marks, E Flores-Giubi, EK Adrian Jr., ES Anton, F Doetsch, F Garcia-Bernal, FH Gage, GJ Francis, HG Kuhn, HT Ghashghaei, I Comte, J Fallon, J Liu, J Wang, JB Cavanagh, JC McGrath, JM Verdi, K Blennow, K Jin, L Avila, LG Rabaneda, LG Rabaneda, M Carrasco, M Dang, M Dang, M Fatt, M Murillo-Carretero, N Geribaldi-Doldan, N Geribaldi-Doldan, ND Zhao, O Gonzalez-Perez, PK Dash, RG Thorne, S Chirumamilla, S Dominguez-Garcia, SW Sunnarborg, V Tropepe, Y Kim   +48 more
core   +2 more sources

Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting

Gels, 2023
Dolutegravir’s therapeutic effectiveness in the management of neuroAIDS is mainly limited by its failure to cross the blood–brain barrier. However, lipid-based nanovesicles such as nanoemulsions have demonstrated their potential for the brain targeting ...
Anroop B. Nair, Sunita Chaudhary, Shery Jacob, Dhwani Patel, Pottathil Shinu, Hiral Shah, Ankit Chaudhary, Bandar Aldhubiab, Rashed M. Almuqbil, Ahmed S. Alnaim, Fatemah Alqattan, Jigar Shah   +11 more
doaj   +1 more source

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges. [PDF]

, 2019
Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could
Barclay WR, Elena Stylianou, Helen McShane, Matthew J. Paul, Rajko Reljic, Resende Co T, Rodriguez A, Uranga S, Wong EA   +8 more
core   +1 more source

Retrospective Study of Midazolam Protocol for Prehospital Behavioral Emergencies [PDF]

, 2020
Introduction: Agitated patients in the prehospital setting pose challenges for both patient care and emergency medical services (EMS) provider safety. Midazolam is frequently used to control agitation in the emergency department setting; however, limited
Huebinger, Ryan M., Markul, Eddie, Pearlman, Kenneth S., Richards, Christopher T., Stein-Spencer, Leslee, Tataris, Katie L., Weber, Joseph M., Zaidi, Hashim Q.   +7 more
core   +1 more source

A promising drug delivery: Intranasal drug delivery system

International Journal of Pharmaceutical Sciences Review and Research, 2021
Pneumonic medication conveyance has acquired gigantic logical interest as of late and has advanced inside the setting of treatment for lung infections. Lung is an appealing climate for bio particles, which are exceptionally presented to enzymatic debasement in the gastrointestinal parcel just as hepatic corruption.
M. Srinivas, Y. Kalyani, J. V. C. Sharma
openaire   +2 more sources

Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves. [PDF]

, 2018
Transgene introgression is a major concern associated with transgenic plant-based vaccines. Agroinfiltration can be used to selectively transform nonreproductive organs and avoid introgression.
Gallo, Richard L, Huang, Chun-Ming, Liu, Pei-Feng, Simmons, Christopher W, Ulrich, Robert G, VanderGheynst, Jean S, Wang, Yanhan   +6 more
core   +3 more sources

Regression of murine lung tumors by the let-7 microRNA. [PDF]

, 2010
MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer.
Bader, AG, Brown, D, Homer, R, Kelnar, K, Medina, PP, Omotola, M, Ruffino, L, Slack, FJ, Trang, P, Weidhaas, JB, Wiggins, JF   +10 more
core   +5 more sources

Intranasal Delivery of Collagen-Loaded Neprilysin Clears Beta-Amyloid Plaques in a Transgenic Alzheimer Mouse Model

Frontiers in Aging Neuroscience, 2021
Alzheimer’s disease (AD) is pathologically characterized by extracellular beta-amyloid (Aβ) plaques and intraneuronal tau tangles in the brain. A therapeutic strategy aims to prevent or clear these Aβ plaques and the Aβ-degrading enzyme neprilysin is a ...
Christian Humpel
doaj   +1 more source