Results 31 to 40 of about 31,838 (257)

Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting

Gels, 2023
Dolutegravir’s therapeutic effectiveness in the management of neuroAIDS is mainly limited by its failure to cross the blood–brain barrier. However, lipid-based nanovesicles such as nanoemulsions have demonstrated their potential for the brain targeting ...
Anroop B. Nair, Sunita Chaudhary, Shery Jacob, Dhwani Patel, Pottathil Shinu, Hiral Shah, Ankit Chaudhary, Bandar Aldhubiab, Rashed M. Almuqbil, Ahmed S. Alnaim, Fatemah Alqattan, Jigar Shah   +11 more
doaj   +1 more source

Intranasal Delivery of Collagen-Loaded Neprilysin Clears Beta-Amyloid Plaques in a Transgenic Alzheimer Mouse Model

Frontiers in Aging Neuroscience, 2021
Alzheimer’s disease (AD) is pathologically characterized by extracellular beta-amyloid (Aβ) plaques and intraneuronal tau tangles in the brain. A therapeutic strategy aims to prevent or clear these Aβ plaques and the Aβ-degrading enzyme neprilysin is a ...
Christian Humpel
doaj   +1 more source

Intranasal Administration of N-acetyl-L-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

Pharmaceutics, 2022
Intranasal administration is a promising route for direct drug delivery to the brain; its combination with nanocarriers enhances delivery. We have previously shown that intranasal administration combined with PEG-PCL-Tat (a nanocarrier) efficiently ...
Takumi Kurano, Takanori Kanazawa, Shingo Iioka, Hiromu Kondo, Yasuhiro Kosuge, Toyofumi Suzuki   +5 more
doaj   +1 more source

Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model

Frontiers in Pharmacology, 2022
Converting a vaccine into a thermostable dry powder is advantageous as it reduces the resource burden linked with the cold chain and provides flexibility in dosage and administration through different routes.
Mellissa Gomez, Mushtaq Ahmed, Shibali Das, Joseph McCollum, Leah Mellett, Rosemary Swanson, Ananya Gupta, Nicholas B. Carrigy, Hui Wang, David Barona, Shital Bachchhav, Alana Gerhardt, Chris Press, Michelle C. Archer, Hong Liang, Emilie Seydoux, Ryan M. Kramer, Philip J. Kuehl, Reinhard Vehring, Shabaana A. Khader, Christopher B. Fox, Christopher B. Fox   +21 more
doaj   +1 more source

Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases

Frontiers in Immunology
Outbreaks of emerging and re-emerging infectious diseases have consistently threatened human health. Since vaccinations are a powerful tool for preventing infectious illnesses, developing new vaccines is essential.
Zhihan Zhang, Yumeng Yang, Liwen Huang, Lei Yuan, Sijian Huang, Zihang Zeng, Yuan Cao, Yuan Cao, Xianghong Wei, Xiaomei Wang, Mingsong Shi, Maohua Zhong   +11 more
doaj   +1 more source

Formulation strategies for nose-to-brain drug delivery in Alzheimer's disease

Health Sciences Review, 2023
Alzheimer's disease (AD) is a neurodegenerative brain disorder that affects memory, thinking, concentration, and judgment, ultimately hindering a person's ability to perform routine daily activities.
Manisha Vohra, Mohammad Amir, Amit Sharma, Sheetu Wadhwa   +3 more
doaj   +1 more source

Intranasal drug delivery by spray and drops

Journal of Pharmacy and Pharmacology, 1985
Abstract A solution of 99m Tc-labelled human serum albumin was administered into the nose as a spray and as one or three drops. The patterns of deposition and the rates of clearance in normal subjects were monitored by gamma scintigraphy. The spray was deposited mainly in the atrium, and cleared slowly into the pharynx.
J G, Hardy, S W, Lee, C G, Wilson
openaire   +2 more sources

Intranasal drug delivery: Unlocking the nose-to-brain route for central nervous system therapies

International Journal of Pharmaceutics: X
Intranasal drug delivery is rapidly gaining momentum as a game-changing approach for central nervous system (CNS) therapies, owing to its ability to bypass the blood-brain barrier (BBB) via olfactory and trigeminal pathways. It also enables systemic drug
Ban Alwali, Thaigarajan Parumasivam, Moawia M. Al-Tabakha   +2 more
doaj   +1 more source

Intranasal Delivery of Antiviral siRNA [PDF]

, 2011
Intranasal administration of synthetic siRNA is an effective modality of RNAi delivery for the prevention and therapy of respiratory diseases, including pulmonary infections. Vehicles used for nasal siRNA delivery include established as well as novel reagents, many of which have been recently optimized.
openaire   +2 more sources

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source