Results 1 to 10 of about 107,310 (319)

Effect of Administration Route on the Pharmacokinetics of Cobalamin in Elderly Patients: A Randomized Controlled Trial

Current Therapeutic Research, 2014
Background: The gold standard for cobalamin deficiency treatment is administration of cobalamin by intramuscular injection. The injection is painful and inconvenient, particularly for elderly persons.
Monique P.H. Tillemans, PharmD, Eline M.V.J. Donders, MD, Sjoerd L. Verweij, PharmD, Ruud T.M. Van der Hoeven, PharmD, Kees J. Kalisvaart, MD, PhD   +4 more
doaj   +1 more source

Intranasal epinephrine in dogs: Pharmacokinetic and heart rate effects

Pharmacology Research & Perspectives, 2020
Epinephrine is the standard of care for the treatment of severe allergy and anaphylaxis. Epinephrine is most often administered through the intramuscular (IM) route via autoinjector.
Kenneth L. Dretchen, Zack Mesa, Matthew Robben, Desmond Slade, Scott Hill, Claire Croutch, Kyle Kappeler, Michael Mesa   +7 more
doaj   +1 more source

Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABAA Receptor Signaling Pathway

Frontiers in Pharmacology, 2018
Cortistatin-14 (CST-14), a recently discovered cyclic neuropeptide, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus. However, the
JinHong Jiang, YaLi Peng, XueYa Liang, Shu Li, Xin Chang, LongFei Li, Min Chang   +6 more
doaj   +1 more source

Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics

, 2017
Ahmed M Fatouh,1 Ahmed H Elshafeey,1,2 Ahmed Abdelbary1 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt; 2School of Pharmacy, University of Waterloo, Waterloo, ON, Canada Purpose: Agomelatine is
Ahmed Fatouh, Fatouh AM, Abdelbary A, Elshafeey AH, Ahmed Abdelbary, Ahmed Elshafeey   +5 more
core   +1 more source

Intranasal Insulin Boosts Gustatory Sensitivity

, 2022
Intranasal insulin has been the subject of attention not only with respect to enhancing memory processes, but also for its anorexic effects, as well as its effects on olfactory sensitivity.
Yang, H., Bruenner, Y.F., Freiherr, J., Rodriguez-Raecke, R.   +3 more
core   +1 more source

Evaluation of Taterapox Virus in Small Animals

Viruses, 2017
Taterapox virus (TATV), which was isolated from an African gerbil (Tatera kempi) in 1975, is the most closely related virus to variola; however, only the original report has examined its virology.
Scott Parker, Ryan Crump, Hollyce Hartzler, R. Mark Buller   +3 more
doaj   +1 more source

Calcitonin Intranasal ??? Unigene

Drugs in R & D, 2004
An intranasal spray formulation of recombinant salmon calcitonin [salcatonin] is in development with Unigene Laboratories as therapy for postmenopausal osteoporosis. Calcitonin is an endogenous polypeptide hormone that regulates calcium and bone metabolism.
openaire   +2 more sources

Optimization of an Intranasal Route for the Delivery of Human Neural Stem Cells to Treat a Neonatal Hypoxic-Ischemic Brain Injury Rat Model

Neuropsychiatric Disease and Treatment, 2022
Siliang Lu,1,2 Ke Li,1,2 Yinxiang Yang,2 Qian Wang,2 Yu Yu,1,2 Zhaoyan Wang,2 Zuo Luan1 1The First Clinical Medical College, Guangxi Medical University, Nanning, 530021, Guangxi, People’s Republic of China; 2Laboratory of Pediatrics, The Sixth ...
Lu S, Li K, Yang Y, Wang Q, Yu Y, Wang Z, Luan Z   +6 more
doaj  

Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men

Frontiers in Endocrinology, 2017
Arginine vasopressin (AVP) and related peptides have diverse effects on social behaviors in vertebrates, sometimes promoting affiliative interactions and sometimes aggressive or antisocial responses.
Daniel Price, Debra Burris, Anna Cloutier, Carol B. Thompson, James K. Rilling, James K. Rilling, James K. Rilling, James K. Rilling, Richmond R. Thompson   +8 more
doaj   +1 more source

The analgesic effect of combined treatment with intranasal S-ketamine and intranasal midazolam compared with morphine patient-controlled analgesia in spinal surgery patients: a pilot study

, 2015
Christine Riediger,1,* Manuel Haschke,2,* Christoph Bitter,3 Thomas Fabbro,4 Stefan Schaeren,5 Albert Urwyler,1 Wilhelm Ruppen1 1Department for Anesthesia, Surgical Intensive Care, Prehospital Emergency Medicine and Pain Therapy, 2Clinical Pharmacology ...
Riediger C, Ruppen W, Bitter C, Fabbro T, Urwyler A, Schaeren S, Haschke M   +6 more
core