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Recent Developments In Brain-Targeted Drug Delivery Systems via Intranasal Route [PDF]
Farmacja Polska, 2023 Diseases of the human nervous system such as neurological infections, Parkinson's, Alzheimer's, and other neurodegenerative diseases are severe pathological diseases and become a public health problem.
Ahmad Ainurofiq +5 more
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Pharmaceutics, 2021 A well-developed lymphatic network is located under the nasal mucosa, and a few drugs that permeate the nasal mucosa are absorbed into the lymphatic capillaries. Lymph from the nasal cavity flows to the cervical lymph nodes (CLNs).
Tomoyuki Furubayashi +4 more
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Pharmaceutics, 2023 Depression is a serious mental disorder and the most prevalent cause of disability and suicide worldwide. Quercetin (QER) demonstrated antidepressant effects in rats exhibiting anxiety and depressive-like behaviors.
Mohammed H. Elkomy +10 more
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Pharmaceutics, 2023 Numerous neurological disorders have a pathophysiology that involves an increase in free radical production in the brain. Quercetin (QER) is a nutraceutical compound that shields the brain against oxidative stress-induced neurodegeneration.
Mohammed H. Elkomy +10 more
doaj +1 more source
Utility of Downstream Biomarkers to Assess and Optimize Intranasal Delivery of Oxytocin
Pharmaceutics, 2022 Oxytocin (OT), a mammalian neurohormone associated with social cognition and behavior, can be administered in its synthetic form intranasally (IN) and impact brain chemistry and behavior.
Megan DuBois +5 more
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Effect of two surfactants on in vitro permeation of butorphanol through horse nasal mucosa
Uniciencia, 2021 The aim of the present study was to evaluate the effect of two surfactants on in vitro permeation of butorphanol through equine nasal mucosa. Franz diffusion cells and equine nasal mucosa were used. Three formulations were developed based on citric acid,
María Inés Velloso +2 more
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Gels, 2023 The present study aimed to prepare, characterize, and evaluate a thermo-responsive sol–gel for intranasal delivery of lamotrigine (LTG), which was designed for sustained drug delivery to treat epilepsy.
Maria Riaz +8 more
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Pharmaceuticals, 2023 Psychiatric and neurodegenerative disorders are amongst the most prevalent and debilitating diseases, but current treatments either have low success rates, greatly due to the low permeability of the blood–brain barrier, and/or are connected to severe ...
Patrícia C. Pires +2 more
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Engineering Proceedings, 2023 The anti-inflammatory drug ketoprofen has shown promising results in the field of drug repurposing for the treatment of brain cancer, but currently developed formulations are for invasive administration (intravenous) and have very limited drug strength ...
Patrícia C. Pires +3 more
doaj +1 more source
TLR2 signaling is required for the innate, but not adaptive response to LVS clpB
Frontiers in Immunology, 2014 Toll-like receptor 2 (TLR2) is the best characterized pattern-recognition receptor for the highly pathogenic intracellular bacterium, Francisella tularensis.
Lydia Marie Roberts +3 more
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