Results 41 to 50 of about 157,530 (311)

A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries [PDF]

, 2020
Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche
A Buffo, A Kamezaki, A Torroglosa, AC Newton, AC Rice, AX Wu-Zhang, BT Susarla, C Kilkenny, C Romero-Grimaldi, CP Blobel, DC Lee, DR Marks, E Flores-Giubi, EK Adrian Jr., ES Anton, F Doetsch, F Garcia-Bernal, FH Gage, GJ Francis, HG Kuhn, HT Ghashghaei, I Comte, J Fallon, J Liu, J Wang, JB Cavanagh, JC McGrath, JM Verdi, K Blennow, K Jin, L Avila, LG Rabaneda, LG Rabaneda, M Carrasco, M Dang, M Dang, M Fatt, M Murillo-Carretero, N Geribaldi-Doldan, N Geribaldi-Doldan, ND Zhao, O Gonzalez-Perez, PK Dash, RG Thorne, S Chirumamilla, S Dominguez-Garcia, SW Sunnarborg, V Tropepe, Y Kim   +48 more
core   +2 more sources

Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice

Viruses, 2020
An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2.
Andrea N. Loes, Lauren E. Gentles, Allison J. Greaney, Katharine H. D. Crawford, Jesse D. Bloom   +4 more
doaj   +1 more source

Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves. [PDF]

, 2018
Transgene introgression is a major concern associated with transgenic plant-based vaccines. Agroinfiltration can be used to selectively transform nonreproductive organs and avoid introgression.
Gallo, Richard L, Huang, Chun-Ming, Liu, Pei-Feng, Simmons, Christopher W, Ulrich, Robert G, VanderGheynst, Jean S, Wang, Yanhan   +6 more
core   +3 more sources

Oxytocin and social pretreatment have similar effects on processing of negative emotional faces in healthy adult males [PDF]

, 2013
Oxytocin has been shown to affect several aspects of human social cognition, including facial emotion processing. There is also evidence that social stimuli (such as eye-contact) can effectively modulate endogenous oxytocin levels.
Hernádi, Anna, Kemerle, Kinga, Topál, József, Vargáné Kis, Anna   +3 more
core   +1 more source

Targeting Intracranial Tumours with a Combination of RNA and Chemotherapy

Pharmaceutics
Glioblastoma multiforme (GBM) is a fast-growing and aggressive brain tumour, which remains largely resistant to treatment; the prognosis for patients is poor, with a median survival time of about 12–18 months, post diagnosis.
Abdulhamid S. Fatani, Andreas G. Schätzlein, Ijeoma F. Uchegbu   +2 more
doaj   +1 more source

Safety and immunogenicity of an intranasal sendai virus-based vaccine for human parainfluenza virus type I and respiratory syncytial virus (SeVRSV) in adults

Human Vaccines & Immunotherapeutics, 2021
SeVRSV is a replication-competent Sendai virus (SeV)-based vaccine carrying the respiratory syncytial virus (RSV) fusion protein (F) gene. Unmanipulated, non-recombinant SeV is a murine parainfluenza virus type 1 (PIV-1) and serves as a Jennerian vaccine
Felicia Scaggs Huang, David I. Bernstein, Karen S. Slobod, Allen Portner, Toru Takimoto, Charles J. Russell, Michael Meagher, Bart G. Jones, Robert E. Sealy, Christopher Coleclough, Kristen Branum, Michelle Dickey, Kristen Buschle, Monica McNeal, Mat Makowski, Aya Nakamura, Julia L. Hurwitz   +16 more
doaj   +1 more source

Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model [PDF]

, 2016
Cryptosporidium is a major cause of severe diarrhea, especially in malnourished children. Using a murine model of C. parvum oocyst challenge that recapitulates clinical features of severe cryptosporidiosis during malnutrition, we interrogated the effect ...
A Blikslager, A Sheoran, AC White, AF Allam, AG Buret, AJ Benitez, AM Marchiando, Ana M. Lara, B Pantenburg, BA Leav, BD Kirkpatrick, BP Coutinho, BS Sheridan, C Maillot, C Wang, Carrie A. Cowardin, Cirle A. Warren, CR Weber, D Mondal, David T. Bolick, DG Agnew, DI Campbell, DT Bolick, DT Bolick, EA Maier, Edna I. Zaenker, EM Brown, F Heller, Francisco Jose Noronha, G Gorfu, G Widmer, GA Preidis, Glynis L. Kolling, Gregory A. Buck, HC Wang, HN Ehigiator, IC Castro, J Liu, James K. Roche, JB Parr, JE Galen, Jerrold R. Turner, JK Roche, JK Tumwine, John H. Moore, Joseph M. Vinetz, JR Mead, JR Turner, JW Priest, JY Chai, K Mølbak, KL Kotloff, KM D'Auria, L Lantier, L Lantier, LA Bartelt, LA Bartelt, LB Costa, LB Costa, Luther A. Bartelt, M Abe, M Barrier, M Deng, M Eguchi, M Jalovecká, M Kváč, M Taniuchi, MA Laxer, MA McArthur, MG Netea, MH Van Regenmortel, MJH Rytter, NR Klatt, OG Azevedo, P Medeiros, PA Manque, PA Manque, PC Okhuysen, PS Korpe, PS Korpe, R Haque, R Wahid, RD Newman, RE Black, Richard L. Guerrant, RP Lazarus, S Bhuiyan, S Lacroix-Lamandé, S Lacroix-Lamandé, S Sagodira, SC Nalle, SM Guk, SM Planchon, SP O'Hara, SP Spencer, SS Ajjampur, T Gebhardt, T Hoang, T Kinugasa, VA Cama, W Checkley, W Checkley, W Checkley, W Chen, YG Zhang, YH Su   +105 more
core   +5 more sources

Atomized Intranasal Sedation Efficacy in Children Undergoing Dental Treatment: A Comparative Randomized Clinical Study

Advances in Human Biology
Introduction: Dental fear and anxiety, especially in children, are the most common reason for avoiding dental treatment. Paediatric dental sedation as a means of pharmacologic behaviour management is gaining momentum to manage young difficult children ...
Megha Patel, Kalpesh Vaishnav, Chintan Patel, Miral Mehta, Santosh Kumar   +4 more
doaj   +1 more source

Effect of Intranasal Remifentanil versus Lidocaine on Facilitation of Laryngeal Mask Airway Insertion and Cardiovascular Response: A Double-blind Clinical Trial Study [PDF]

Bulletin of Emergency and Trauma
Objective: This study aimed to assess and compare the effects of intranasal administration of lidocaine andremifentanil on the condition of LMA insertion and cardiovascular response.Methods: From March 2019 to March 2020, this double-blind randomized ...
Hamidreza Shetabi, hossein Mahjoubipour, mona bahmani   +2 more
doaj   +1 more source

Intranasal Ketamine for Depression in Adults: A Systematic Review and Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials

Frontiers in Psychology, 2021
BackgroundThere is growing interest in glutamatergic agents as a treatment for depression, especially intranasal ketamine, which has become a hot topic in recent years.
Dongjiao An, Changwei Wei, Jing Wang, Anshi Wu   +3 more
doaj   +1 more source