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Brain-targeted drug delivery - nanovesicles directed to specific brain cells by brain-targeting ligands [PDF]
Journal of NanobiotechnologyNeurodegenerative diseases are characterized by extensive loss of function or death of brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging, with a low success rate this far.
Ricardo Moreira +3 more
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PTX-loaded, polysorbate 80-functionalized brain-targeting pullulan nanoparticles for drug delivery [PDF]
Frontiers in PharmacologyBrain-targeted drug delivery remains a major challenge in pharmaceutical research. In this study, four types of polysorbate 80 and cholesterol-modified pullulan polymers (CHPP) were synthesized and self-assembled into nanoparticles (CHPP NPs) for brain ...
Huabing Yuan +11 more
doaj +2 more sources
A Novel Brain-Targeting Nanoparticle Loaded with Biatractylolide and Its Protective Effect on Alzheimer’s Disease [PDF]
PharmaceuticalsBackground: To enhance the bioavailability and neuroprotective efficacy of biatractylolide against Alzheimer’s disease by developing a novel Tween-80-modified pullulan–chenodeoxycholic acid nanoparticle as a delivery vehicle.
Qianmei Hu +9 more
doaj +2 more sources
Evaluation of Brain Targeting and Antipsychotic Activity of Nasally Administrated Ziprasidone Lipid–Polymer Hybrid Nanocarriers [PDF]
Pharmaceuticals, 2023 The feasibility of using lipid–polymer hybrid (LPH) nanocarriers as a potential platform for the intranasal delivery of ziprasidone (ZP), a second-generation antipsychotic, was explored.
Hadel A. Abo El-Enin +6 more
doaj +2 more sources
Progress and perspectives on targeting nanoparticles for brain drug delivery
Acta Pharmaceutica Sinica B, 2016 Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain, it is a challenge to treat central nervous system disorders pharmacologically. The development of nanotechnology provides potential to overcome this problem.
Huile Gao
doaj +3 more sources
Pharmaceutics, 2021 Neurodegenerative diseases (NDs) represent a heterogeneous group of aging-related disorders featured by progressive impairment of motor and/or cognitive functions, often accompanied by psychiatric disorders.
Claudia Riccardi +4 more
doaj +1 more source
Communications Biology, 2021 Kostrikov et al. report a deficiency of transcardial perfusion in brain tumor vasculature, which leads to exaggeration of drug extravasation measurements.
Serhii Kostrikov +10 more
doaj +1 more source
Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain
Biomedicines, 2021 The treatment of central nervous system (CNS) pathologies is severely hampered by the presence of tightly regulated CNS barriers that restrict drug delivery to the brain.
Marie J. Pauwels +2 more
doaj +1 more source
Pharmaceutics, 2023 Orally administered antipsychotic drugs are the first-line treatment for psychotic disorders, such as schizophrenia and bipolar disorder. Nevertheless, adverse drug reactions jeopardize clinical outcomes, resulting in patient non-compliance.
Maria Daniela Ferreira +4 more
doaj +1 more source
Brain Targeting of Antidepressant and Anxiolytic Drugs
Engineering Proceedings, 2022 Depression and anxiety are high incidence and debilitating psychiatric disorders, usually treated by antidepressant or anxiolytic drug administration, respectively.
Jéssica Antunes +3 more
doaj +1 more source