Results 1 to 10 of about 965,485 (298)

Brain-targeted drug delivery - nanovesicles directed to specific brain cells by brain-targeting ligands [PDF]

Journal of Nanobiotechnology
Neurodegenerative diseases are characterized by extensive loss of function or death of brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging, with a low success rate this far.
Ricardo Moreira, Clévio Nóbrega, Luís Pereira de Almeida, Liliana Mendonça   +3 more
doaj   +6 more sources

A Novel Brain-Targeting Nanoparticle Loaded with Biatractylolide and Its Protective Effect on Alzheimer’s Disease [PDF]

Pharmaceuticals
Background: To enhance the bioavailability and neuroprotective efficacy of biatractylolide against Alzheimer’s disease by developing a novel Tween-80-modified pullulan–chenodeoxycholic acid nanoparticle as a delivery vehicle.
Qianmei Hu, Candi Liu, Jiawang Tan, Jixiang Wang, Hao Yang, Yi Liu, Haochu Mao, Zixuan Jiang, Xing Feng, Xiaojun Tao   +9 more
doaj   +2 more sources

Evaluation of Brain Targeting and Antipsychotic Activity of Nasally Administrated Ziprasidone Lipid–Polymer Hybrid Nanocarriers [PDF]

Pharmaceuticals, 2023
The feasibility of using lipid–polymer hybrid (LPH) nanocarriers as a potential platform for the intranasal delivery of ziprasidone (ZP), a second-generation antipsychotic, was explored.
Hadel A. Abo El-Enin, Alaa S. Tulbah, Hany W. Darwish, Rania Salama, Ibrahim A. Naguib, Heba A. Yassin, Hend Mohamed Abdel-Bar   +6 more
doaj   +2 more sources

Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: I. Optimization, Characterization, Brain Localization, and Cytotoxic Studies [PDF]

Pharmaceutics, 2023
Numerous neurological disorders have a pathophysiology that involves an increase in free radical production in the brain. Quercetin (QER) is a nutraceutical compound that shields the brain against oxidative stress-induced neurodegeneration.
Mohammed H. Elkomy, Randa Mohammed Zaki, Omar A. Alsaidan, Mohammed Elmowafy, Ameeduzzafar Zafar, Khaled Shalaby, Mohamed A. Abdelgawad, Fatma I. Abo El-Ela, Mostafa E. Rateb, Ibrahim A. Naguib, Hussein M. Eid   +10 more
doaj   +2 more sources

PTX-loaded, polysorbate 80-functionalized brain-targeting pullulan nanoparticles for drug delivery [PDF]

Frontiers in Pharmacology
Brain-targeted drug delivery remains a major challenge in pharmaceutical research. In this study, four types of polysorbate 80 and cholesterol-modified pullulan polymers (CHPP) were synthesized and self-assembled into nanoparticles (CHPP NPs) for brain ...
Huabing Yuan, Huabing Yuan, Lu Han, Lu Han, Hao Deng, Yue Tan, Yi Yang, Yi Liu, Jiaxin Ying, Mengqi Fang, Hui Wei, Zhihe Tao   +11 more
doaj   +2 more sources

Development and Evaluation of Nanosuspension Loaded Nanogel of Nortriptyline HCl for Brain Delivery

Engineering Proceedings, 2023
Nanogel systems loaded with nanosuspension area promising approach tonose-to-brain delivery in order to reduce the dose and dosing frequency and also improve the bioavailability of the drug.
Akash J. Amkar, Bhushan R. Rane, Ashish S. Jain   +2 more
doaj   +1 more source

Optical tissue clearing and machine learning can precisely characterize extravasation and blood vessel architecture in brain tumors

Communications Biology, 2021
Kostrikov et al. report a deficiency of transcardial perfusion in brain tumor vasculature, which leads to exaggeration of drug extravasation measurements.
Serhii Kostrikov, Kasper B. Johnsen, Thomas H. Braunstein, Johann M. Gudbergsson, Frederikke P. Fliedner, Elisabeth A. A. Obara, Petra Hamerlik, Anders E. Hansen, Andreas Kjaer, Casper Hempel, Thomas L. Andresen   +10 more
doaj   +1 more source

Brain-Targeted Intranasal Delivery of Zotepine Microemulsion: Pharmacokinetics and Pharmacodynamics

Pharmaceutics, 2022
The purpose of our study was to improve the solubility, bioavailability, and efficacy of zotepine (ZTP) by brain-targeted intranasal delivery of microemulsion (ME) and its physicochemical properties, the pharmacokinetic and pharmacodynamic parameters ...
Sravanthi Reddy Pailla, Sunitha Sampathi, Vijayabhaskarreddy Junnuthula, Sravya Maddukuri, Sujatha Dodoala, Sathish Dyawanapelly   +5 more
doaj   +1 more source

Lipid Nanocarriers Overlaid with Chitosan for Brain Delivery of Berberine via the Nasal Route

Pharmaceuticals, 2022
This research aimed to design, optimize, and evaluate berberine-laden nanostructured lipid carriers overlaid with chitosan (BER-CTS-NLCs) for efficient brain delivery via the intranasal route.
Hadel A. Abo El-Enin, Mohammed H. Elkomy, Ibrahim A. Naguib, Marwa F. Ahmed, Omar A. Alsaidan, Izzeddin Alsalahat, Mohammed M. Ghoneim, Hussein M. Eid   +7 more
doaj   +1 more source

Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting

Gels, 2023
Dolutegravir’s therapeutic effectiveness in the management of neuroAIDS is mainly limited by its failure to cross the blood–brain barrier. However, lipid-based nanovesicles such as nanoemulsions have demonstrated their potential for the brain targeting ...
Anroop B. Nair, Sunita Chaudhary, Shery Jacob, Dhwani Patel, Pottathil Shinu, Hiral Shah, Ankit Chaudhary, Bandar Aldhubiab, Rashed M. Almuqbil, Ahmed S. Alnaim, Fatemah Alqattan, Jigar Shah   +11 more
doaj   +1 more source