Results 11 to 20 of about 551,653 (258)
Bioengineering & Translational Medicine, 2022 Alzheimer's disease (AD) is an aging‐related neurodegenerative disease. The main pathological features of AD are β‐amyloid protein (Aβ) deposition and tau protein hyperphosphorylation. Currently, there are no effective drugs for the etiological treatment
Ruiyi Zhou +8 more
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Targeting Dystroglycan in the Brain [PDF]
Neuron, 2003 The dystrophin-glycoprotein complex is a multisubunit complex that connects the extracellular matrix components to the cytoskeletal matrix of muscle fiber cells and is required for muscle integrity. Mutations in this complex are associated with muscular dystrophy.
Montanaro, F., Carbonetto, S.
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Nanogels as novel drug nanocarriers for CNS drug delivery
Frontiers in Molecular Biosciences, 2023 Nanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases.
V. Manimaran +14 more
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Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders
Frontiers in Aging Neuroscience, 2023 Neurodegenerative diseases (NDs) have a slow onset and are usually detected late during disease. NDs are often difficult to cure due to the presence of the blood–brain barrier (BBB), which makes it difficult to find effective treatments and drugs ...
Renjie Pan +9 more
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Pharmaceutics, 2023 Numerous neurological disorders have a pathophysiology that involves an increase in free radical production in the brain. Quercetin (QER) is a nutraceutical compound that shields the brain against oxidative stress-induced neurodegeneration.
Mohammed H. Elkomy +10 more
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Brain-based target expansion [PDF]
Proceedings of the 27th annual ACM symposium on User interface software and technology, 2014 The bubble cursor is a promising cursor expansion technique, improving a user's movement time and accuracy in pointing tasks. We introduce a brain-based target expansion system, which improves the efficacy of bubble cursor by increasing the expansion of high importance targets at the optimal time based on brain measurements correlated to a particular ...
Daniel Afergan +6 more
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Development and Evaluation of Nanosuspension Loaded Nanogel of Nortriptyline HCl for Brain Delivery
Engineering Proceedings, 2023 Nanogel systems loaded with nanosuspension area promising approach tonose-to-brain delivery in order to reduce the dose and dosing frequency and also improve the bioavailability of the drug.
Akash J. Amkar +2 more
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Brain-Targeted Intranasal Delivery of Zotepine Microemulsion: Pharmacokinetics and Pharmacodynamics
Pharmaceutics, 2022 The purpose of our study was to improve the solubility, bioavailability, and efficacy of zotepine (ZTP) by brain-targeted intranasal delivery of microemulsion (ME) and its physicochemical properties, the pharmacokinetic and pharmacodynamic parameters ...
Sravanthi Reddy Pailla +5 more
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Lipid Nanocarriers Overlaid with Chitosan for Brain Delivery of Berberine via the Nasal Route
Pharmaceuticals, 2022 This research aimed to design, optimize, and evaluate berberine-laden nanostructured lipid carriers overlaid with chitosan (BER-CTS-NLCs) for efficient brain delivery via the intranasal route.
Hadel A. Abo El-Enin +7 more
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Gels, 2023 Dolutegravir’s therapeutic effectiveness in the management of neuroAIDS is mainly limited by its failure to cross the blood–brain barrier. However, lipid-based nanovesicles such as nanoemulsions have demonstrated their potential for the brain targeting ...
Anroop B. Nair +11 more
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