Results 11 to 20 of about 965,485 (298)
Progress and perspectives on targeting nanoparticles for brain drug delivery
Acta Pharmaceutica Sinica B, 2016 Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain, it is a challenge to treat central nervous system disorders pharmacologically. The development of nanotechnology provides potential to overcome this problem.
Huile Gao
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Pharmaceutics, 2022 At present, brain diseases affect one in six people worldwide, and they include a wide range of neurological diseases from Alzheimer’s and Parkinson’s diseases to epilepsy, brain injuries, brain cancer, neuroinfections and strokes [...]
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Pharmaceutics, 2022 This research aimed to boost granisetron (GS) delivery to the brain via the intranasal route to better manage chemotherapy-induced emesis. Glycerol monooleate (GMO), Poloxamer 407 (P 407) and Tween 80 (T 80) were used to formulate GS-loaded cubosomes (GS-
Essam M. Eissa +8 more
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Pharmaceutics, 2023 Alzheimer’s disease, a progressive neurodegenerative condition, is characterized by a gradual decline in cognitive functions. Current treatment approaches primarily involve the administration of medications through oral, parenteral, and transdermal ...
Sayali Dighe +4 more
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Pharmaceutics, 2020 Nose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood−brain barrier (BBB) and the ...
Paolo Giunchedi +2 more
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Pharmaceutics, 2021 Neurodegenerative diseases (NDs) represent a heterogeneous group of aging-related disorders featured by progressive impairment of motor and/or cognitive functions, often accompanied by psychiatric disorders.
Claudia Riccardi +4 more
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Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells [PDF]
, 2020 Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable.
Bultynck, Geert +10 more
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Targeted Therapies in Rare Brain Tumours [PDF]
International Journal of Molecular Sciences, 2021 Rare central nervous system (CNS) tumours represent a unique challenge. Given the difficulty of conducting dedicated clinical trials, there is a lack of therapies for these tumours supported by high quality evidence, and knowledge regarding the impact of standard treatments (i.e., surgery, radiotherapy or chemotherapy) is commonly based on ...
Bruno F. +4 more
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Three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT). [PDF]
, 2017 Optical methods capable of manipulating neural activity with cellular resolution and millisecond precision in three dimensions will accelerate the pace of neuroscience research. Existing approaches for targeting individual neurons, however, fall short of
Adesnik, Hillel +5 more
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Targeted therapy in brain metastasis [PDF]
Current Opinion in Oncology, 2012 To review the state of the art and new developments in the field of targeted agents for brain metastases.The huge amount of information on new molecular compounds and the advances in understanding the molecular pathways that mediate brain colonization have led to an increase of interest in preclinical and clinical investigations in the field of brain ...
SOFFIETTI, Riccardo +2 more
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