Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain
Biomedicines, 2021 The treatment of central nervous system (CNS) pathologies is severely hampered by the presence of tightly regulated CNS barriers that restrict drug delivery to the brain.
Marie J. Pauwels +2 more
doaj +1 more source
Brain Targeting Nanomedicines: Pitfalls and Promise. [PDF]
Int J NanomedicineBrain diseases are the most devastating problem among the world's increasingly aging population, and the number of patients with neurological diseases is expected to increase in the future. Although methods for delivering drugs to the brain have advanced significantly, none of these approaches provide satisfactory results for the treatment of brain ...
Kakinen A +4 more
europepmc +5 more sources
Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. [PDF]
, 2017 Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain.
Bazinet, Richard P +11 more
core +1 more source
Post-ischaemic immunological response in the brain: targeting microglia in ischaemic stroke therapy [PDF]
, 2020 Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke.
Chen, Ruoli +4 more
core +3 more sources
Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic-Ischemic Brain Damage in Neonatal Rats. [PDF]
, 2015 c-Jun N-terminal kinase (JNK) plays a key role in the regulation of neuronal apoptosis. Previous studies have revealed that forkhead transcription factor (FOXO3a) is a critical effector of JNK-mediated tumor suppression.
Li, Deyuan +8 more
core +5 more sources
Pharmaceutics, 2023 Orally administered antipsychotic drugs are the first-line treatment for psychotic disorders, such as schizophrenia and bipolar disorder. Nevertheless, adverse drug reactions jeopardize clinical outcomes, resulting in patient non-compliance.
Maria Daniela Ferreira +4 more
doaj +1 more source
Brain Targeting of Antidepressant and Anxiolytic Drugs
Engineering Proceedings, 2022 Depression and anxiety are high incidence and debilitating psychiatric disorders, usually treated by antidepressant or anxiolytic drug administration, respectively.
Jéssica Antunes +3 more
doaj +1 more source
The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice. [PDF]
, 2018 Zinc (Zn2+) is a pleiotropic modulator of the neuronal and brain activity. The disruption of intraneuronal Zn2+ levels triggers neurotoxic processes and affects neuronal functioning.
Bomba, Manuela +13 more
core +3 more sources
Bioengineering & Translational Medicine, 2022 Alzheimer's disease (AD) is an aging‐related neurodegenerative disease. The main pathological features of AD are β‐amyloid protein (Aβ) deposition and tau protein hyperphosphorylation. Currently, there are no effective drugs for the etiological treatment
Ruiyi Zhou +8 more
doaj +1 more source
Brain changes associated with cognitive and emotional factors in chronic pain : a systematic review [PDF]
, 2017 An emerging technique in chronic pain research is MRI, which has led to the understanding that chronic pain patients display brain structure and function alterations.
Alarcon +67 more
core +2 more sources