Results 21 to 30 of about 551,653 (258)

Intranasal Delivery of Granisetron to the Brain via Nanostructured Cubosomes-Based In Situ Gel for Improved Management of Chemotherapy-Induced Emesis

Pharmaceutics, 2022
This research aimed to boost granisetron (GS) delivery to the brain via the intranasal route to better manage chemotherapy-induced emesis. Glycerol monooleate (GMO), Poloxamer 407 (P 407) and Tween 80 (T 80) were used to formulate GS-loaded cubosomes (GS-
Essam M. Eissa, Mohammed H. Elkomy, Hussein M. Eid, Adel A. Ali, Mohammed A. S. Abourehab, Amal M. Alsubaiyel, Ibrahim A. Naguib, Izzeddin Alsalahat, Amira H. Hassan   +8 more
doaj   +1 more source

Noninvasive gene targeting to the brain [PDF]

Proceedings of the National Academy of Sciences, 2000
Gene therapy of the brain is hindered by the presence of the blood–brain barrier (BBB), which prevents the brain uptake of bloodborne gene formulations. Exogenous genes have been expressed in the brain after invasive routes of administration, such as craniotomy or intracarotid arterial infusion of noxious agents causing BBB disruption.
N, Shi, W M, Pardridge
openaire   +2 more sources

Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management

Pharmaceutics, 2023
Alzheimer’s disease, a progressive neurodegenerative condition, is characterized by a gradual decline in cognitive functions. Current treatment approaches primarily involve the administration of medications through oral, parenteral, and transdermal ...
Sayali Dighe, Sunil Jog, Munira Momin, Sujata Sawarkar, Abdelwahab Omri   +4 more
doaj   +1 more source

Brain Targeting of Citicoline Sodium via Hyaluronic Acid-Decorated Novel Nano-Transbilosomes for Mitigation of Alzheimer’s Disease in a Rat Model: Formulation, Optimization, in vitro and in vivo Assessment

International Journal of Nanomedicine, 2022
Kariman M AbouElhassan,1,2 Hatem A Sarhan,1 Amal K Hussein,1 Ashraf Taye,3 Yasmin M Ahmed,4 Mohamed A Safwat5 1Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt; 2Faculty of Pharmacy, South Valley University, Qena ...
AbouElhassan KM, Sarhan HA, Hussein AK, Taye A, Ahmed YM, Safwat MA   +5 more
doaj  

Nanoemulsions for “Nose-to-Brain” Drug Delivery

Pharmaceutics, 2019
The blood⁻brain barrier (BBB) plays a fundamental role in protecting the brain from toxic substances and therefore also controls and restricts the entry of therapeutic agents. The nasal administration of drugs using the nose-to-brain pathway allows
Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovanna Rassu, Paolo Giunchedi   +6 more
doaj   +1 more source

Leptin targets in the mouse brain [PDF]

Journal of Comparative Neurology, 2009
AbstractThe central actions of leptin are essential for homeostatic control of adipose tissue mass, glucose metabolism, and many autonomic and neuroendocrine systems. In the brain, leptin acts on numerous different cell types via the long‐form leptin receptor (LepRb) to elicit its effects.
Michael M, Scott, Jennifer L, Lachey, Scott M, Sternson, Charlotte E, Lee, Carol F, Elias, Jeffrey M, Friedman, Joel K, Elmquist   +6 more
openaire   +2 more sources

Nose-to-Brain Delivery

Pharmaceutics, 2020
Nose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood−brain barrier (BBB) and the ...
Paolo Giunchedi, Elisabetta Gavini, Maria Cristina Bonferoni   +2 more
doaj   +1 more source

Uptake in the Central Nervous System of Geraniol Oil Encapsulated in Chitosan Oleate Following Nasal and Oral Administration

Pharmaceutics, 2019
The pharmacological activities of geraniol include anticancer and neuroprotective properties. However, its insolubility in water easily induces separation from aqueous formulations, causing administration difficulties.
Maria Cristina Bonferoni, Luca Ferraro, Barbara Pavan, Sarah Beggiato, Elena Cavalieri, Paolo Giunchedi, Alessandro Dalpiaz   +6 more
doaj   +1 more source

Brain Targeting Nanomedicines: Pitfalls and Promise. [PDF]

Int J Nanomedicine
Brain diseases are the most devastating problem among the world's increasingly aging population, and the number of patients with neurological diseases is expected to increase in the future. Although methods for delivering drugs to the brain have advanced significantly, none of these approaches provide satisfactory results for the treatment of brain ...
Kakinen A, Jiang Y, Davis TP, Teesalu T, Saarma M.   +4 more
europepmc   +8 more sources

Progress in Procalcitonin Detection Based on Immunoassay

Research
Procalcitonin (PCT) serves as a crucial biomarker utilized in diverse clinical contexts, including sepsis diagnosis and emergency departments. Its applications extend to identifying pathogens, assessing infection severity, guiding drug administration ...
Jiayue Huang, Yan Zu, Lexiang Zhang, Wenguo Cui   +3 more
doaj   +1 more source