Nanogels as novel drug nanocarriers for CNS drug delivery
Frontiers in Molecular Biosciences, 2023 Nanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases.
V. Manimaran +14 more
doaj +1 more source
Brain–computer interface game applications for combined neurofeedback and biofeedback treatment for children on the autism spectrum [PDF]
, 2014 Individuals with Autism Spectrum Disorder (ASD) show deficits in social and communicative skills, including imitation, empathy, and shared attention, as well as restricted interests and repetitive patterns of behaviors.
Friedrich, Elisabeth V. C. +5 more
core +4 more sources
Dual-targeting for brain-specific drug delivery: synthesis and biological evaluation
Drug Delivery, 2018 Ibuprofen is one of the most potent non-steroid anti-inflammatory drugs (NSAIDs) and plays an important role in the treatment of neurodegenerative diseases.
Qiming Yue +9 more
doaj +1 more source
Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders
Frontiers in Aging Neuroscience, 2023 Neurodegenerative diseases (NDs) have a slow onset and are usually detected late during disease. NDs are often difficult to cure due to the presence of the blood–brain barrier (BBB), which makes it difficult to find effective treatments and drugs ...
Renjie Pan +9 more
doaj +1 more source
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module. [PDF]
, 2019 Blood vessels in the CNS form a specialized and critical structure, the blood-brain barrier (BBB). We present a resource to understand the molecular mechanisms that regulate BBB function in health and dysfunction during disease.
Aydin, Sidar +16 more
core +1 more source
Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]
, 2017 There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas +7 more
core +2 more sources
Targeting Brain-Eating Amoebae Infections [PDF]
ACS Chemical Neuroscience, 2017 Brain infections due to Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri often lead to death. Despite differences in the preferential sites of infection in the brain, the mode of delivery of drugs is often intravenous. Here, we discuss targeted therapeutic approach to affect parasite viability without affecting the host cells, with an ...
Naveed Ahmed, Khan +2 more
openaire +2 more sources
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Targeting Dystroglycan in the Brain [PDF]
Neuron, 2003 The dystrophin-glycoprotein complex is a multisubunit complex that connects the extracellular matrix components to the cytoskeletal matrix of muscle fiber cells and is required for muscle integrity. Mutations in this complex are associated with muscular dystrophy.
Montanaro, F., Carbonetto, S.
openaire +2 more sources
Progress in Procalcitonin Detection Based on Immunoassay
ResearchProcalcitonin (PCT) serves as a crucial biomarker utilized in diverse clinical contexts, including sepsis diagnosis and emergency departments. Its applications extend to identifying pathogens, assessing infection severity, guiding drug administration ...
Jiayue Huang +3 more
doaj +1 more source