Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation [PDF]
Brain endothelial cells constitute the major cellular element of the highly specialized blood–brain barrier (BBB) and thereby contribute to CNS homeostasis by restricting entry of circulating leukocytes and blood-borne molecules into the CNS.
Arie Reijerkerk +6 more
core +3 more sources
Targeting Brain Tissue Oxygenation in Traumatic Brain Injury [PDF]
The management of patients with traumatic brain injury has evolved in the last several years, due to the introduction of new, invasive monitoring devices. The ability to monitor parameters other than measurements related to pressures has generated substantial interest.
Ross P, Martini +2 more
openaire +2 more sources
Docosahexaenoic acid–mediated, targeted and sustained brain delivery of curcumin microemulsion
We disclose microemulsions (ME) of curcumin (CUR) with docosahexaenoic acid (DHA)-rich oil (CUR DHA ME) for targeted delivery to the brain. MEs of CUR (5 mg/mL) with and without DHA-rich oil (CUR Capmul ME) suitable for intravenous and intranasal ...
Rajshree L. Shinde, Padma V. Devarajan
doaj +1 more source
New players in the preventive treatment of migraine. [PDF]
Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed ...
Mitsikostas, Dimos D, Rapoport, Alan M
core +3 more sources
Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans [PDF]
Transcranial focused ultrasound (tFUS) is an emerging method for non-invasive neuromodulation akin to transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS).
Allen, John J. B. +6 more
core +1 more source
Fatma M Elsharkawy,1 Maha M Amin,2 Hesham A Shamsel-Din,3 Walaa Ibrahim,3 Ahmed B Ibrahim,3 Sinar Sayed2 1Regulatory Affairs Department, Al Andalous for Pharmaceutical Industries, Giza, Egypt; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty
M Elsharkawy F +5 more
doaj
Targeted radiotherapy of brain tumours [PDF]
The utility of external beam radiotherapy for the treatment of malignant brain tumours is compromised by the need to avoid excessive radiation damage to normal CNS tissues. This review describes the current status of targeted radiotherapy, an alternative strategy for brain tumour treatment that offers the exciting prospect of increasing the specificity
openaire +2 more sources
Clinical Insights Into Hypercalcemia of Malignancy in Childhood
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley +1 more source
Targeted Therapies in Brain Metastases [PDF]
Brain metastases are a major clinical problem in patients with advanced breast cancer, lung cancer, melanoma, and renal cell carcinoma. Initial treatment for patients with brain metastases typically includes radiotherapy, either whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), or both.
openaire +2 more sources
Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence. [PDF]
Targeting mitochondrial ion homeostasis using Kaempferol, a mitochondrial Ca2+ uniporter channel activator, improves energy metabolism and behavior soon after a traumatic brain injury (TBI) in developing rats.
Chitturi, Jyothsna +5 more
core +1 more source

