Results 61 to 70 of about 965,485 (298)

Targeting microglia in brain disorders

Science, 2019
The heterogeneity of brain immune cells could be exploited ...
Priller, Josef, Prinz, Marco
openaire   +5 more sources

An Insight to Brain Targeting Utilizing Polymeric Nanoparticles: Effective Treatment Modalities for Neurological Disorders and Brain Tumor

Frontiers in Bioengineering and Biotechnology, 2022
The delivery of therapeutic molecules to the brain remains an unsolved problem to the researchers due to the existence of the blood–brain barrier (BBB), which halts the entry of unwanted substances to the brain.
Annu, Ali Sartaj, Zufika Qamar, Shadab Md, Shadab Md, Nabil A. Alhakamy, Nabil A. Alhakamy, Sanjula Baboota, Javed Ali   +8 more
doaj   +1 more source

A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons. [PDF]

, 2019
Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications.
Dong, Jie-Xian, Dumitras, Camelia, Gong, Belvin, Kirmiz, Michael, Lee, Yongam, Moreno, Claudia M, Murray, Karl D, Palacio, Stephanie, Sando, Richard, Santana, L Fernando, Südhof, Thomas C, Trimmer, James S   +11 more
core  

Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting [PDF]

, 2000
PURPOSE: To prepare polymeric vesicles and niosomes bearing glucose or transferrin ligands for drug targeting. METHODS: A glucose-palmitoyl glycol chitosan (PGC) conjugate was synthesised and glucose-PGC polymeric vesicles prepared by sonication of ...
Couet, W., Dufès, Christine, Gray, A.I., Olivier, J.C., Schätzlein, A.G., Tetley, L., Uchegbu, I.F., Watson, D.G.   +7 more
core   +1 more source

Brain Targeting of Citicoline Sodium via Hyaluronic Acid-Decorated Novel Nano-Transbilosomes for Mitigation of Alzheimer’s Disease in a Rat Model: Formulation, Optimization, in vitro and in vivo Assessment

International Journal of Nanomedicine, 2022
Kariman M AbouElhassan,1,2 Hatem A Sarhan,1 Amal K Hussein,1 Ashraf Taye,3 Yasmin M Ahmed,4 Mohamed A Safwat5 1Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt; 2Faculty of Pharmacy, South Valley University, Qena ...
AbouElhassan KM, Sarhan HA, Hussein AK, Taye A, Ahmed YM, Safwat MA   +5 more
doaj  

Nanoemulsions for “Nose-to-Brain” Drug Delivery

Pharmaceutics, 2019
The blood⁻brain barrier (BBB) plays a fundamental role in protecting the brain from toxic substances and therefore also controls and restricts the entry of therapeutic agents. The nasal administration of drugs using the nose-to-brain pathway allows
Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovanna Rassu, Paolo Giunchedi   +6 more
doaj   +1 more source

Nasal Delivery of Cinnarizine Thermo- and Ion-Sensitive In Situ Hydrogels for Treatment of Microwave-Induced Brain Injury

Gels, 2022
(1) Background: When the body is exposed to microwave radiation, the brain is more susceptible to damage than other organs. However, few effective drugs are available for the treatment of microwave-induced brain injury (MIBI) because most drugs are ...
Yuanyuan Zhang, Qian Li, Jinglu Hu, Chunqing Wang, Delian Wan, Qi Li, Qingwei Jiang, Lina Du, Yiguang Jin   +8 more
doaj   +1 more source

Toxicology and efficacy of tumor-targeting Salmonella typhimurium A1-R compared to VNP 20009 in a syngeneic mouse tumor model in immunocompetent mice. [PDF]

, 2017
Salmonella typhimurium A1-R (S. typhimurium A1-R) attenuated by leu and arg auxotrophy has been shown to target multiple types of cancer in mouse models.
Cao, Wenluo, Dry, Sarah M, Eilber, Fritz C, Hoffman, Robert M, Kiyuna, Tasuku, Li, Shukuan, Li, Yunfeng, Ma, Huaiyu, Murakami, Takashi, Nelson, Scott D, Singh, Arun S, Toneri, Makoto, Wang, Xiaoen, Zhang, Nan, Zhang, Yong, Zhao, Ming   +15 more
core   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Targeted Brain Biopsy [PDF]

Neurosurgery, 1993
Dennis Y. Wen, Walter A. Hall, David A. Miller, Edward L. Seljeskog, Robert E. Maxwell   +4 more
  +4 more sources