Results 11 to 20 of about 119,783 (316)
Intranasal (IN) COVID-19 vaccines - a breakthrough [PDF]
, 2023 Emerging variants of COVID-19 have threatened the effectiveness of intramuscular (IM) vaccines since that are made to target only the spike protein.
Ramandeep Singh Gambhir +11 more
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Intranasal dexmedetomidine and intranasal ketamine association allows shorter induction time for pediatric sedation compared to intranasal dexmedetomidine and oral midazolam [PDF]
, 2022 Background: Non-painful diagnostic procedures require an inactive state for a prolonged time, so that sedation is often needed in younger children to perform the procedures.
Trombetta, Andrea +15 more
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Journal of Neuroendocrinology, 2021 Abstract The intranasal (IN) route enables the delivery of insulin to the central nervous system in the relative absence of systemic uptake and related peripheral side effects. Intranasally administered insulin is assumed to travel along olfactory and adjacent pathways and has been shown to rapidly accumulate in cerebrospinal fluid ...
openaire +3 more sources
Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]
, 2012 Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Shivangi Jaiswal +3 more
core +1 more source
Different Methods and Formulations of Drugs and Vaccines for Nasal Administration
Pharmaceutics, 2022 Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has
Junhu Tai +5 more
doaj +1 more source
Delayed Disease in Cynomolgus Macaques Exposed to Ebola Virus by an Intranasal Route
Frontiers in Immunology, 2021 Ebola virus remains a significant public health concern due to high morbidity and mortality rates during recurrent outbreaks in endemic areas. Therefore, the development of countermeasures against Ebola virus remains a high priority, and requires the ...
Sara C. Johnston +6 more
doaj +1 more source
Cells, 2022 The central nervous system (CNS) has, among all organ systems in the human body, the highest failure rate of traditional small-molecule drug development, ranging from 80–100% depending on the area of disease research.
Meenakshi Bose +3 more
doaj +1 more source
Recent progress in the intranasal PLGA-based drug delivery for neurodegenerative diseases treatment [PDF]
Iranian Journal of Basic Medical Sciences, 2023 One of the most challenging problems of the current treatments of neurodegenerative diseases is related to the permeation and access of most therapeutic agents to the central nervous system (CNS), prevented by the blood-brain barrier (BBB).
Nasim Aghaei Delche +6 more
doaj +1 more source
Lipid Nanocarriers Overlaid with Chitosan for Brain Delivery of Berberine via the Nasal Route
Pharmaceuticals, 2022 This research aimed to design, optimize, and evaluate berberine-laden nanostructured lipid carriers overlaid with chitosan (BER-CTS-NLCs) for efficient brain delivery via the intranasal route.
Hadel A. Abo El-Enin +7 more
doaj +1 more source
Journal of Mazandaran University of Medical Sciences, 2021 Background and purpose: Pain control is a major issue after surgery and the most widely used drug is morphine. There are several methods for administration of morphine.
Nasrin Ghaffari +2 more
doaj