Results 11 to 20 of about 157,530 (311)
Journal of Neuroendocrinology, 2021 Abstract The intranasal (IN) route enables the delivery of insulin to the central nervous system in the relative absence of systemic uptake and related peripheral side effects. Intranasally administered insulin is assumed to travel along olfactory and adjacent pathways and has been shown to rapidly accumulate in cerebrospinal fluid ...
openaire +3 more sources
Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1 [PDF]
, 2011 Background: H5N1 influenza vaccines, including live intranasal, appear to be relatively less immunogenic compared to seasonal analogs. The main influenza virus surface glycoprotein hemagglutinin (HA) of highly pathogenic avian influenza viruses (HPAIV ...
Batishchev, Oleg V. +22 more
core +13 more sources
Using intranasal corticosteroids [PDF]
Canadian Medical Association Journal, 2021 About 5% of Canadians are affected by sinonasal inflammation.[1][1] There is broad expert consensus supporting the effectiveness of intranasal corticosteroids for treating allergic and nonallergic rhinitis, acute rhinosinusitis and chronic rhinosinusitis with and without nasal polyposis.[2][2],[3 ...
Fowler, James, Sowerby, Leigh J
openaire +2 more sources
A Compensatory Liability Regime to Promote the Exchange of Microbial Genetic Resources for Research and Benefit Sharing [PDF]
, 2011 Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules ...
Andersen, Hanne +10 more
core +2 more sources
Pharmaceutics, 2022 Intranasal administration has gained an increasing interest for brain drug delivery since it allows direct transport through neuronal pathways, which can be quite advantageous for central nervous system disorders, such as depression and anxiety ...
Margarida Alberto +3 more
doaj +1 more source
Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]
, 2012 Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Danish Ahmed +3 more
core +2 more sources
Tropical Medicine and Infectious Disease, 2022 Melatonin (MLT) is now emerging as one of the universally accepted immunostimulators with broad applications in medicine. It is a biological manipulator of the immune system, including mucosal ones. MLT was encapsulated in solid lipid nanoparticles (SLNs)
Doaa E. Said +5 more
doaj +1 more source
Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]
, 2003 The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William +5 more
core +3 more sources
Retrospective Study of Midazolam Protocol for Prehospital Behavioral Emergencies [PDF]
, 2020 Introduction: Agitated patients in the prehospital setting pose challenges for both patient care and emergency medical services (EMS) provider safety. Midazolam is frequently used to control agitation in the emergency department setting; however, limited
Huebinger, Ryan M. +7 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 We evaluated the immunogenicity and protective ability of a chimpanzee replication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in golden Syrian hamsters.
Shen Wang +20 more
doaj +1 more source