Results 11 to 20 of about 31,838 (257)
Recent Developments In Brain-Targeted Drug Delivery Systems via Intranasal Route [PDF]
Farmacja Polska, 2023 Diseases of the human nervous system such as neurological infections, Parkinson's, Alzheimer's, and other neurodegenerative diseases are severe pathological diseases and become a public health problem.
Ahmad Ainurofiq +5 more
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Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of anesthesia. [PDF]
PLoS ONE, 2012 Intranasal instillation is a widely used procedure for pneumonic delivery of drugs, vaccine candidates, or infectious agents into the respiratory tract of research mice.
Mark A Miller +7 more
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Frontiers in Pharmacology, 2022 Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics
Manisha Pandey +4 more
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Strategies for intranasal delivery of vaccines [PDF]
Drug Delivery and Translational Research, 2012 The vast majority of human pathogens colonize and invade at the mucosal surfaces. Preventing infection at these sites via mucosally active vaccines is a promising and rational approach for vaccine development. However, it is only recently that the stimulation of local immunity at the mucosal surfaces has become a primary objective in addition to ...
Zaman, Mehfuz +2 more
openaire +5 more sources
Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery
Pharmaceutics, 2023 Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles produced from cholesterol and phospholipids. Recently, liposomes have been widely administered intranasally for systemic and brain delivery. From the nasal cavity, liposome-
Van-An Duong +2 more
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Frontiers in Pharmacology, 2022 The intranasal route has emerged as a promising strategy that can direct delivery of drugs into the systemic circulation because the high-vascularized nasal cavity, among other advantages, avoids the hepatic first-pass metabolism.
Jeehye Maeng, Kyunglim Lee
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Pharmaceutics, 2023 Intranasal delivery of drugs offers several potential benefits related to ease of delivery, rapid onset, and patient experience, which may be of particular relevance to patients with central nervous system (CNS) conditions who experience acute events ...
Stuart Madden +2 more
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Design and Application in Delivery System of Intranasal Antidepressants
Frontiers in Bioengineering and Biotechnology, 2020 One of the major reasons why depressed patients fail their treatment course is the existence of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central nervous system (CNS).
Jingying Xu +4 more
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Zaporožskij Medicinskij Žurnal, 2021 Development of novel medications for delivery of active ingredients with systemic absorption and high bioavailability is an actual challenge for modern pharmaceutical and medical science.
B. S. Burlaka, I. F. Bielenichev
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Intranasal Delivery of Morphine
The Journal of Pharmacology and Experimental Therapeutics, 2002 Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a highly increased absorption with a 5 ...
L, Illum +7 more
openaire +2 more sources