Results 11 to 20 of about 57,259 (320)

Differential Biodistribution of Adenoviral-Vectored Vaccine Following Intranasal and Endotracheal Deliveries Leads to Different Immune Outcomes

Frontiers in Immunology, 2022
Infectious diseases of the respiratory tract are one of the top causes of global morbidity and mortality with lower respiratory tract infections being the fourth leading cause of death.
Vidthiya Jeyanathan, Vidthiya Jeyanathan, Sam Afkhami, Sam Afkhami, Michael R. D’Agostino, Michael R. D’Agostino, Anna Zganiacz, Anna Zganiacz, Xueya Feng, Xueya Feng, Matthew S. Miller, Matthew S. Miller, Mangalakumari Jeyanathan, Mangalakumari Jeyanathan, Michael R. Thompson, Zhou Xing, Zhou Xing   +16 more
doaj   +1 more source

Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System

Pharmaceutics, 2022
The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB.
Oxana Semyachkina-Glushkovskaya, Alexander Shirokov, Inna Blokhina, Valeria Telnova, Elena Vodovozova, Anna Alekseeva, Ivan Boldyrev, Ivan Fedosov, Alexander Dubrovsky, Alexandr Khorovodov, Andrey Terskov, Arina Evsukova, Daria Elovenko, Viktoria Adushkina, Maria Tzoy, Ilana Agranovich, Jürgen Kurths, Edik Rafailov   +17 more
doaj   +1 more source

The hidden obstacles to intranasal insulin delivery: A narrative review

Journal of Diabetology, 2023
A large number of people are suffering with one or the other type of diabetes around the globe. Insulin has proven to be beneficial for the treatment of both types of diabetes.
Ujjawal Rawat, Ambika Choudhary, Piyush Mittal, Anurag Verma   +3 more
doaj   +1 more source

Recent Developments In Brain-Targeted Drug Delivery Systems via Intranasal Route [PDF]

Farmacja Polska, 2023
Diseases of the human nervous system such as neurological infections, Parkinson's, Alzheimer's, and other neurodegenerative diseases are severe pathological diseases and become a public health problem.
Ahmad Ainurofiq, Aji Prasetya, Bingah Ginanjar Rahayu, Muhammad Syayiq Al Qadri, Myrat Kovusov, Ophira Evangelista Putri Laksono   +5 more
doaj   +1 more source

Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of anesthesia. [PDF]

PLoS ONE, 2012
Intranasal instillation is a widely used procedure for pneumonic delivery of drugs, vaccine candidates, or infectious agents into the respiratory tract of research mice.
Mark A Miller, Jennifer M Stabenow, Jyothi Parvathareddy, Andrew J Wodowski, Thomas P Fabrizio, Xiaowen R Bina, Lillian Zalduondo, James E Bina   +7 more
doaj   +1 more source

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System

Frontiers in Pharmacology, 2022
Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics
Manisha Pandey, Neha Jain, Jovita Kanoujia, Zahid Hussain, Bapi Gorain   +4 more
doaj   +1 more source

Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery

Pharmaceutics, 2023
Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles produced from cholesterol and phospholipids. Recently, liposomes have been widely administered intranasally for systemic and brain delivery. From the nasal cavity, liposome-
Van-An Duong, Thi-Thao-Linh Nguyen, Han-Joo Maeng   +2 more
doaj   +1 more source

Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery [PDF]

Frontiers in Chemistry, 2020
في السنوات الأخيرة، أثبتت المواد الهجينة النانوية المتقدمة التي تمت معالجتها كمستحضرات صيدلانية أنها مفيدة للغاية. التريبتان، مثل السوماتريبتان داخل الأنف المتاح تجاريًا (SMT)، هي أدوية تستخدم في علاج أعراض الصداع النصفي المؤلمة. ومع ذلك، فإن فعالية SMT محدودة بسبب أليفتها العالية للماء وضعف التصاق الغشاء المخاطي.
Lígia Nunes de Morais Ribeiro, Gustavo Henrique Rodrigues da Silva, Verônica Muniz Couto, Simone R. Castro, Márcia Cristina Breitkreitz, Carolina Martínez, Daniela E. Igartúa, María Jimena Prieto, Eneida de Paula   +8 more
openaire   +4 more sources

Systemic and brain delivery of antidiabetic peptides through nasal administration using cell-penetrating peptides

Frontiers in Pharmacology, 2022
The intranasal route has emerged as a promising strategy that can direct delivery of drugs into the systemic circulation because the high-vascularized nasal cavity, among other advantages, avoids the hepatic first-pass metabolism.
Jeehye Maeng, Kyunglim Lee
doaj   +1 more source

Optimizing Absorption for Intranasal Delivery of Drugs Targeting the Central Nervous System Using Alkylsaccharide Permeation Enhancers

Pharmaceutics, 2023
Intranasal delivery of drugs offers several potential benefits related to ease of delivery, rapid onset, and patient experience, which may be of particular relevance to patients with central nervous system (CNS) conditions who experience acute events ...
Stuart Madden, Enrique Carrazana, Adrian L. Rabinowicz   +2 more
doaj   +1 more source