Chitosan Nanoparticles for Intranasal Drug Delivery [PDF]
PharmaceuticsThis manuscript explores the use of nanostructured chitosan for intranasal drug delivery, targeting improved therapeutic outcomes in neurodegenerative diseases, psychiatric care, pain management, vaccination, and diabetes treatment.
Hossein Omidian +3 more
doaj +7 more sources
Intranasal drug delivery: opportunities and toxicologic challenges during drug development. [PDF]
Drug Deliv Transl Res, 2022 Abstract Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has increased. This review article summarises information on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery
Keller LA, Merkel O, Popp A.
europepmc +5 more sources
Editorial: Intranasal Drug Delivery: Challenges and Opportunities [PDF]
Frontiers in Pharmacology, 2022 Ana Fortuna +4 more
doaj +8 more sources
Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery [PDF]
Molecules, 2015 The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and ...
Prabagar Balakrishnan +6 more
doaj +5 more sources
Intranasal drug delivery: Unlocking the nose-to-brain route for central nervous system therapies [PDF]
International Journal of Pharmaceutics: XIntranasal drug delivery is rapidly gaining momentum as a game-changing approach for central nervous system (CNS) therapies, owing to its ability to bypass the blood-brain barrier (BBB) via olfactory and trigeminal pathways. It also enables systemic drug
Ban Alwali +2 more
doaj +2 more sources
Biomedical applications of artificial exosomes for intranasal drug delivery. [PDF]
Front Bioeng Biotechnol, 2023 Intranasal administration offers a feasible, non-invasive method of delivering therapeutic drugs to the brain, allowing therapeutic pharmaceuticals to be administered directly to the central nervous system by bypassing the blood-brain barrier. Furthermore, exosomes are naturally occurring cell-derived nanovesicles that can serve as carriers for a ...
Zhao J +5 more
europepmc +4 more sources
Nanoemulsions and Microemulsions for Intranasal Drug Delivery: A Bibliometric Analysis and Emerging Trends (2004–2024) [PDF]
PharmaceuticsBackground/Objectives: Nanoemulsions and microemulsions are promising drug delivery systems capable of enhancing the solubility, stability, and bioavailability of active pharmaceutical ingredients, particularly for central nervous system (CNS) disorders.
Ariane Krause Padilha Lorenzett +3 more
doaj +2 more sources
Factors affecting nasal drug delivery and design strategies for intranasal drug delivery. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2023 Intranasal drug delivery system is a non-invasive drug delivery route with the advantages of no first-pass effect, rapid effect and brain targeting. It is a feasible alternative to drug delivery via injection, and a potential drug delivery route for the central nervous system.
Hu X, Yue X, Wu C, Zhang X.
europepmc +3 more sources
Intranasal Drug Delivery Technology in the Treatment of Central Nervous System Diseases: Challenges, Advances, and Future Research Directions [PDF]
PharmaceuticsAs population aging becomes an increasingly critical global issue, the incidence of central nervous system (CNS) diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke, has risen sharply. However, the blood–brain barrier (BBB)
Xunxun Wu +8 more
doaj +2 more sources
A new brain drug delivery strategy: focused ultrasound-enhanced intranasal drug delivery. [PDF]
PLoS ONE, 2014 Central nervous system (CNS) diseases are difficult to treat because of the blood-brain barrier (BBB), which prevents most drugs from entering into the brain.
Hong Chen +5 more
doaj +5 more sources