Results 31 to 40 of about 22,711 (279)

Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider

Asian Journal of Pharmaceutical Sciences, 2023
The number of people with Alzheimer's disease (AD) is increasing annually, with the nidus mainly concentrated in the cortex and hippocampus. Despite of numerous efforts, effective treatment of AD is still facing great challenges due to the blood brain ...
Xin Shen, Zhixiang Cui, Yidan Wei, Yingnan Huo, Duo Yu, Xin Zhang, Shirui Mao   +6 more
doaj   +1 more source

Design and Application in Delivery System of Intranasal Antidepressants

Frontiers in Bioengineering and Biotechnology, 2020
One of the major reasons why depressed patients fail their treatment course is the existence of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central nervous system (CNS).
Jingying Xu, Jingying Xu, Jiangang Tao, Jiangang Tao, Jidong Wang   +4 more
doaj   +1 more source

Emulsomes: new lipidic carriers for drug delivery with special mention to brain drug transport

Future Journal of Pharmaceutical Sciences, 2023
Background Emulsomes are a type of lipid-based nanoparticle that consists of a solid lipid core surrounded by a phospholipid bilayer and have shown promise as drug delivery systems for a variety of applications. The major advantageous aspect of employing
Shivam Singh, Kunal Khurana, Shikha Baghel Chauhan, Indu Singh   +3 more
doaj   +1 more source

Optimizing Absorption for Intranasal Delivery of Drugs Targeting the Central Nervous System Using Alkylsaccharide Permeation Enhancers

Pharmaceutics, 2023
Intranasal delivery of drugs offers several potential benefits related to ease of delivery, rapid onset, and patient experience, which may be of particular relevance to patients with central nervous system (CNS) conditions who experience acute events ...
Stuart Madden, Enrique Carrazana, Adrian L. Rabinowicz   +2 more
doaj   +1 more source

Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting

Gels, 2023
Dolutegravir’s therapeutic effectiveness in the management of neuroAIDS is mainly limited by its failure to cross the blood–brain barrier. However, lipid-based nanovesicles such as nanoemulsions have demonstrated their potential for the brain targeting ...
Anroop B. Nair, Sunita Chaudhary, Shery Jacob, Dhwani Patel, Pottathil Shinu, Hiral Shah, Ankit Chaudhary, Bandar Aldhubiab, Rashed M. Almuqbil, Ahmed S. Alnaim, Fatemah Alqattan, Jigar Shah   +11 more
doaj   +1 more source

Rapid and Widespread Distribution of Intranasal Small Extracellular Vesicles Derived from Mesenchymal Stem Cells throughout the Brain Potentially via the Perivascular Pathway

Pharmaceutics, 2023
Intranasal administration is a promising strategy to enhance the delivery of the sEVsomes-based drug delivery system to the central nervous system (CNS).
Weiwei Shen, Tongyao You, Wenqing Xu, Yanan Xie, Yingzhe Wang, Mei Cui   +5 more
doaj   +1 more source

Transmucosal nasal drug delivery : systemic bioavailability of nasally applied midazolam [PDF]

, 2008
Transmucosal nasal drug delivery is a drug delivery option for challenging clinical situations where common drug administrations (e.g., intravenous, intramuscular, or oral) are inapplicable.
Suter-Zimmermann, Katja
core   +1 more source

Intranasal Administration of N-acetyl-L-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

Pharmaceutics, 2022
Intranasal administration is a promising route for direct drug delivery to the brain; its combination with nanocarriers enhances delivery. We have previously shown that intranasal administration combined with PEG-PCL-Tat (a nanocarrier) efficiently ...
Takumi Kurano, Takanori Kanazawa, Shingo Iioka, Hiromu Kondo, Yasuhiro Kosuge, Toyofumi Suzuki   +5 more
doaj   +1 more source

Intranasal drug delivery by spray and drops

Journal of Pharmacy and Pharmacology, 1985
Abstract A solution of 99m Tc-labelled human serum albumin was administered into the nose as a spray and as one or three drops. The patterns of deposition and the rates of clearance in normal subjects were monitored by gamma scintigraphy. The spray was deposited mainly in the atrium, and cleared slowly into the pharynx.
J G, Hardy, S W, Lee, C G, Wilson
openaire   +2 more sources

Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications

, 2023
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Jesus Vicente de Julián-Ortiz, Raquel Taléns-Visconti, Nácher Alonso, Amparo, Amparo Nácher, Taléns Visconti, Raquel, Vila Busó, Ofelia, Ofelia Vila-Busó, Octavio Diez-Sales, Julián Ortiz, Jesús Vicente de, Díez Sales, Octavio   +9 more
core   +1 more source