Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System [PDF]
Pharmaceutics, 2022 Neurological diseases continue to increase in prevalence worldwide. Combined with the lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a significant and growing burden on healthcare systems and societies.
Tyler P Crowe, Walter H Hsu
exaly +3 more sources
Recent Developments In Brain-Targeted Drug Delivery Systems via Intranasal Route [PDF]
Farmacja Polska, 2023 Diseases of the human nervous system such as neurological infections, Parkinson's, Alzheimer's, and other neurodegenerative diseases are severe pathological diseases and become a public health problem.
Ahmad Ainurofiq +5 more
doaj +2 more sources
Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery
Pharmaceutics, 2023 Nanomedicine is currently focused on the design and development of nanocarriers that enhance drug delivery to the brain to address unmet clinical needs for treating neuropsychiatric disorders and neurological diseases.
Rebecca Maher +5 more
doaj +2 more sources
Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System [PDF]
Pharmaceutics, 2022 The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB.
Oxana Semyachkina-Glushkovskaya +17 more
doaj +2 more sources
Intranasal Therapy in Palliative Care
PharmaceuticsIn recent years, the use of the intranasal route has been actively explored as a possible drug delivery method in the palliative patient population. There are reports demonstrating the effectiveness of nasally administered medications that are routinely ...
Anna Ingielewicz, Robert K. Szymczak
doaj +2 more sources
Intranasal administration in modulating depressive-like behavior and reconstructing treatment paradigms through neuroinflammation and neurotrophic pathways [PDF]
Journal of NanobiotechnologyIntranasal administration, as a non-invasive brain-targeted delivery strategy, offers a promising approach for the treatment of central nervous system disorders, particularly depression.
Juan An +4 more
doaj +2 more sources
Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery [PDF]
Current Medicinal Chemistry, 2019 There is always a need for alternative and efficient methods of drug delivery. The nasal cavity can be considered as a non-invasive and efficient route of administration. It has been used for local, systemic, brain targeting, and vaccination delivery.
Areen Alshweiat +2 more
exaly +4 more sources
Pharmaceutics, 2023 Rotigotine (RTG) is a non-ergoline dopamine agonist and an approved drug for treating Parkinson’s disease. However, its clinical use is limited due to various problems, viz. poor oral bioavailability (
Paramita Saha +4 more
doaj +2 more sources
Imaging of intranasal drug delivery to the brain. [PDF]
Am J Nucl Med Mol Imaging, 2020 Intranasal (IN) delivery is a rapidly developing area for therapies with great potential for the treatment of central nervous system (CNS) diseases. Moreover, in vivo imaging is becoming an important part of therapy assessment, both clinically in humans and translationally in animals.
Veronesi MC +5 more
europepmc +2 more sources
Pharmacokinetic Modeling of the “Nose-to-Brain” Pathway as Demonstrated by Intranasal Administration of Cannabidiol-Loaded Nanoparticles [PDF]
PharmaceuticalsBackground/Objectives: Cannabidiol is a non-psychoactive substance that possesses properties suitable for the treatment of several disorders related to the central nervous system.
Ilya Eydelman +2 more
doaj +2 more sources