Results 41 to 50 of about 22,711 (279)
Pharmaceutics, 2022 Efforts in discovering new and effective neurotherapeutics are made daily, although most fail to reach clinical trials. The main reason is their poor bioavailability, related to poor aqueous solubility, limited permeability through biological membranes ...
Sara Meirinho +4 more
doaj +1 more source
Pharmaceutics, 2018 The blood-brain barrier and the blood-cerebrospinal fluid barrier are major obstacles in central nervous system (CNS) drug delivery, since they block most molecules from entering the brain.
Stella Gänger, Katharina Schindowski
doaj +1 more source
Intranasal drug delivery in pediatric emergency departments: brief review and future outlook [PDF]
Pediatric Emergency Medicine Journal, 2023 This review aims to provide an overview and update of current literature on the use of intranasal (IN) drug delivery in pediatric emergency medicine (PEM), in terms of the anatomy, physiology, pharmacokinetics, limitations, drug delivery methods ...
Christopher Hugh McClean +4 more
doaj +1 more source
Radiolabeled Risperidone microSPECT/CT Imaging for Intranasal Implant Studies Development
Pharmaceutics, 2023 The use of intranasal implantable drug delivery systems has many potential advantages for the treatment of different diseases, as they can provide sustained drug delivery, improving patient compliance.
Jon Ander Simón +9 more
doaj +1 more source
, 2021 Carrier peptides, termed protein transduction domains (PTDs), serve as provide promising vehicles for intranasal delivery of macromolecular drugs. A mutant PTD derived from human translationally controlled tumor protein (TCTP-PTD 13, MIIFRALISHKK) was ...
이경림, 권영주
core +2 more sources
Pharmaceuticals, 2022 A liposphere system for intranasal delivery of quetiapine fumarate (QTF) was created to assess the potential for enhanced drug delivery. We investigated the effects of particle size, entrapment effectiveness, poly dispersibility index, and pluronic ...
Randa Mohammed Zaki +8 more
doaj +1 more source
Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients
, 2022 As a mental disease in modern society, depression shows an increasing occurrence, with low cure rate and high recurrence rate. It has become the most disabling disease in the world.
Zhang, Danshen +13 more
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Inhaled Insulin: Intrapulmonary or Intranasal?
, 2012 Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Shivangi Jaiswal +3 more
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Computational, In Vitro, and In Vivo Models for Nose-to-Brain Drug Delivery Studies
, 2023 Direct nose-to-brain drug delivery offers the opportunity to treat central nervous system disorders more effectively due to the possibility of drug molecules reaching the brain without passing through the blood–brain barrier.
Radka Boyuklieva +2 more
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Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery
, 2014 Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics.
Conway, Barbara R +3 more
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