Results 21 to 30 of about 57,259 (320)
Design and Application in Delivery System of Intranasal Antidepressants
Frontiers in Bioengineering and Biotechnology, 2020 One of the major reasons why depressed patients fail their treatment course is the existence of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central nervous system (CNS).
Jingying Xu +4 more
doaj +1 more source
Strategies for intranasal delivery of vaccines [PDF]
Drug Delivery and Translational Research, 2012 The vast majority of human pathogens colonize and invade at the mucosal surfaces. Preventing infection at these sites via mucosally active vaccines is a promising and rational approach for vaccine development. However, it is only recently that the stimulation of local immunity at the mucosal surfaces has become a primary objective in addition to ...
Zaman, Mehfuz +2 more
openaire +3 more sources
Zaporožskij Medicinskij Žurnal, 2021 Development of novel medications for delivery of active ingredients with systemic absorption and high bioavailability is an actual challenge for modern pharmaceutical and medical science.
B. S. Burlaka, I. F. Bielenichev
doaj +1 more source
Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]
, 2012 Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Danish Ahmed +3 more
core +2 more sources
Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery
Pharmaceutics, 2023 Nanomedicine is currently focused on the design and development of nanocarriers that enhance drug delivery to the brain to address unmet clinical needs for treating neuropsychiatric disorders and neurological diseases.
Rebecca Maher +5 more
doaj +1 more source
Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]
, 2003 The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William +5 more
core +3 more sources
Intranasal Delivery of Morphine
The Journal of Pharmacology and Experimental Therapeutics, 2002 Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a highly increased absorption with a 5 ...
L, Illum +7 more
openaire +2 more sources
Nasal Drug Delivery Systems: An Overview [PDF]
, 2015 Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R. +3 more
core +1 more source
Pharmaceutics, 2021 The fate of intranasal aerosolized radiolabeled polymeric micellar nanoparticles (LPNPs) was tracked with positron emission tomography/computer tomography (PET/CT) imaging in a rat model to measure nose-to-brain delivery.
Michael C. Veronesi +7 more
doaj +1 more source
Drug Delivery, 2019 Inherited retinopathies typically lead to photoreceptor loss and severe visual impairments in the subjects. Intranasal administration is an efficient approach to deliver therapeutic agents to the targeted tissue.
Ye Tao +7 more
doaj +1 more source