Results 21 to 30 of about 31,838 (257)

Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders

Molecules, 2020
Although the global prevalence of neurological disorders such as Parkinson’s disease, Alzheimer’s disease, glioblastoma, epilepsy, and multiple sclerosis is steadily increasing, effective delivery of drug molecules in therapeutic quantities to the ...
Salman Ul Islam, Adeeb Shehzad, Muhammad Bilal Ahmed, Young Sup Lee   +3 more
doaj   +1 more source

Intranasal delivery of imaging agents to the brain. [PDF]

Theranostics
The potential of intranasal administered imaging agents to altogether bypass the blood-brain barrier offers a promising non-invasive approach for delivery directly to the brain. This review provides a comprehensive analysis of the advancements and challenges of delivering neuroimaging agents to the brain by way of the intranasal route, focusing on the ...
Almahmoud A, Parekh HS, Paterson BM, Tupally KR, Vegh V.   +4 more
europepmc   +5 more sources

Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery [PDF]

Frontiers in Chemistry, 2020
في السنوات الأخيرة، أثبتت المواد الهجينة النانوية المتقدمة التي تمت معالجتها كمستحضرات صيدلانية أنها مفيدة للغاية. التريبتان، مثل السوماتريبتان داخل الأنف المتاح تجاريًا (SMT)، هي أدوية تستخدم في علاج أعراض الصداع النصفي المؤلمة. ومع ذلك، فإن فعالية SMT محدودة بسبب أليفتها العالية للماء وضعف التصاق الغشاء المخاطي.
Lígia Nunes de Morais Ribeiro, Gustavo Henrique Rodrigues da Silva, Verônica Muniz Couto, Simone R. Castro, Márcia Cristina Breitkreitz, Carolina Martínez, Daniela E. Igartúa, María Jimena Prieto, Eneida de Paula   +8 more
openaire   +4 more sources

Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery

Pharmaceutics, 2023
Nanomedicine is currently focused on the design and development of nanocarriers that enhance drug delivery to the brain to address unmet clinical needs for treating neuropsychiatric disorders and neurological diseases.
Rebecca Maher, Almudena Moreno-Borrallo, Dhruvi Jindal, Binh T. Mai, Eduardo Ruiz-Hernandez, Andrew Harkin   +5 more
doaj   +1 more source

In situ Intranasal Delivery Systems: Application Prospects and Main Pharmaceutical Aspects of Development (Review)

Разработка и регистрация лекарственных средств, 2021
Introduction. Intranasal delivery of in situ gel-forming systems is a complex but promising direction. Due to the high cost of developing a new chemical object or genetically engineered modification of biological molecules, pharmaceutical companies are ...
E. O. Bakhrushina, N. B. Demina, M. M. Shumkova, P. S. Rodyuk, D. S. Shulikina, I. I. Krasnyuk   +5 more
doaj   +1 more source

Intranasal delivery of Thyroid hormones in MCT8 deficiency [PDF]

PLOS ONE, 2020
Loss of function mutations in the gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to severe neurodevelopmental defects in humans associated with a specific thyroid hormone phenotype manifesting high serum 3,5,3'-triiodothyronine (T3) and low thyroxine (T4) levels.
Carmen Grijota-Martínez, Soledad Bárez-López, Eva Ausó, Samuel Refetoff, William H. Frey, Ana Guadaño-Ferraz   +5 more
openaire   +9 more sources

Intranasal administration of erythropoietin rescues the photoreceptors in degenerative retina: a noninvasive method to deliver drugs to the eye

Drug Delivery, 2019
Inherited retinopathies typically lead to photoreceptor loss and severe visual impairments in the subjects. Intranasal administration is an efficient approach to deliver therapeutic agents to the targeted tissue.
Ye Tao, Chong Li, Anhui Yao, Yingxin Qu, Limin Qin, Zuojun Xiong, Jianbin Zhang, Weiwen Wang   +7 more
doaj   +1 more source

Aerosolized In Vivo 3D Localization of Nose-to-Brain Nanocarrier Delivery Using Multimodality Neuroimaging in a Rat Model—Protocol Development

Pharmaceutics, 2021
The fate of intranasal aerosolized radiolabeled polymeric micellar nanoparticles (LPNPs) was tracked with positron emission tomography/computer tomography (PET/CT) imaging in a rat model to measure nose-to-brain delivery.
Michael C. Veronesi, Brian D. Graner, Shih-Hsun Cheng, Marta Zamora, Hamideh Zarrinmayeh, Chin-Tu Chen, Sudip K. Das, Michael W. Vannier   +7 more
doaj   +1 more source

Intranasal delivery of cells to the brain

European Journal of Cell Biology, 2009
The safety and efficacy of cell-based therapies for neurodegenerative diseases depends on the mode of cell administration. We hypothesized that intranasally administered cells could bypass the blood-brain barrier by migrating from the nasal mucosa through the cribriform plate along the olfactory neural pathway into the brain and cerebrospinal fluid ...
Lusine, Danielyan, Richard, Schäfer, Andreas, von Ameln-Mayerhofer, Marine, Buadze, Julia, Geisler, Tim, Klopfer, Ute, Burkhardt, Barbara, Proksch, Stephan, Verleysdonk, Miriam, Ayturan, Gayane H, Buniatian, Christoph H, Gleiter, William H, Frey   +12 more
openaire   +2 more sources

Synthesis of an insulin-loaded mucoadhesive nanoparticle designed for intranasal administration: focus on new diffusion media

Frontiers in Pharmacology, 2023
Intranasal administration is a drug delivery approach to provide a non-invasive pharmacological response in the central nervous system with relatively small peripheral side effects. To improve the residence time of intranasal drug delivery systems in the
Tahereh Jamshidnejad-Tosaramandani, Tahereh Jamshidnejad-Tosaramandani, Tahereh Jamshidnejad-Tosaramandani, Soheila Kashanian, Soheila Kashanian, Isaac Karimi, Helgi B. Schiöth   +6 more
doaj   +1 more source