Results 21 to 30 of about 59,442 (261)

Pre-clinical study of protective potency of candidate recombinant live pertussis vaccine for intranasal administration

open access: yesЖурнал микробиологии, эпидемиологии и иммунобиологии, 2019
The aim of present research is studying of protective potency of candidate recombinant live pertussis vaccine (RLPV) for intranasal administration.Materials and methods.
L. N. Sinyashina   +4 more
doaj   +1 more source

Intranasal calcitonin gene-related peptide administration impairs fear memory retention in mice through the PKD/p-HDAC5/Npas4 pathway

open access: yesScientific Reports, 2022
The calcitonin gene-related peptide (CGRP) suppresses fear memory retention in mice. Although intracerebroventricular administration of CGRP alters the fear memory processes, making it a promising therapeutic strategy for post-traumatic stress disorder ...
Narumi Hashikawa-Hobara   +3 more
doaj   +1 more source

Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms

open access: yesDrug Design, Development and Therapy, 2022
Jinghui Wang,1 Yuhua Zhang,2 Meifeng Zhang,1 Si Sun,1 Yang Zhong,1 Lei Han,1 Yitong Xu,1 Dong Wan,3 Junhui Zhang,4 Huifeng Zhu1 1College of Pharmaceutical Sciences & College of Chinese Medicine, Southwest University, Chongqing, 400715, People’s Republic ...
Wang J   +9 more
doaj  

Marketing research on intranasal medicines of domestic market

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Modern development of biopharmaceutical research in world science and practice promotes the use of new dosage forms or administration routes of active substances in the human body.
B. S. Burlaka   +2 more
doaj   +1 more source

Intranasal administration of dantrolene increased brain concentration and duration.

open access: yesPLoS ONE, 2020
Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang   +7 more
doaj   +1 more source

Electrocardiogram Assessment in Chough (Pyrrhocorax pyrrhocorax) Following Intranasal Administration of Anesthetics [PDF]

open access: yesIranian Journal of Veterinary Surgery, 2017
Objective- The objective of the present study was to define electrocardiographic data following intranasal administration of diazepam, midazolam and xylazine with or without Ketamine in Chough.Design- To determine the heart effects of anesthetics in ...
Majid Taati, Abbas Raisi
doaj   +1 more source

Study of embryotoxic effects of intranasally administred desloratadine on laboratory animals. [PDF]

open access: yesMedičnì Perspektivi, 2017
The study was conducted to detect possible changes in embryogenesis and negative effects of third generation antihistamine – desloratadine – after intranasal administration of 1.3 mg/m3 and 13.0 mg/m3 of the substance to laboratory animals during their ...
Т. А. Alekhina   +2 more
doaj   +2 more sources

Clinical and pharmacokinetics overview of intranasal administration of fentanyl

open access: yesHeliyon, 2023
Due to the presence of large surfaces and high blood supply, drug delivery through the nasal route of administration is the appropriate route to administrate drugs with rapid onsets of action. Bypassing first-pass metabolism can increase drug bioavailability.
Samaneh Nakhaee   +2 more
openaire   +3 more sources

The pharmacokinetics of intranasal droperidol in volunteers characterised via population modelling

open access: yesSAGE Open Medicine, 2018
Background: Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol.
Isabelle Cooper   +3 more
doaj   +1 more source

Development and evaluation of vinpocetine inclusion complex for brain targeting

open access: yesAsian Journal of Pharmaceutical Sciences, 2015
The objective of this paper is to prepare vinpocetine (VIN) inclusion complex and evaluate its brain targeting effect after intranasal administration. In the present study, VIN inclusion complex was prepared in order to increase its solubility. Stability
Jiaojiao Ding, Jinfeng Li, Shirui Mao
doaj   +1 more source

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