Bioavailability of butorphanol after intranasal administration to horses. [PDF]
Bulgarian Journal of Veterinary Medicine, 2020 The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or ...
V. Ferreira +2 more
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Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study [PDF]
PLoS ONE, 2015 The use of intranasal oxytocin (OT) in research has become increasingly important over the past decade. Although researchers have acknowledged a need for further investigation of the physiological effects of intranasal administration, few studies have ...
Katie Daughters +2 more
exaly +3 more sources
Pharmacokinetic Modeling of the “Nose-to-Brain” Pathway as Demonstrated by Intranasal Administration of Cannabidiol-Loaded Nanoparticles [PDF]
PharmaceuticalsBackground/Objectives: Cannabidiol is a non-psychoactive substance that possesses properties suitable for the treatment of several disorders related to the central nervous system.
Ilya Eydelman +2 more
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Brain Research Bulletin, 2023 While skeletal muscle creatine levels can be enhanced by exogenous creatine supplementation, the elevation of brain creatine levels with oral creatine administration remains a challenge due to a lack of effective transportation of creatine through the ...
Kaiqing Chen, Xiaoping Hu
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Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications
Pharmaceutics, 2023 Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Raquel Taléns-Visconti +4 more
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Intranasal administration of dantrolene increased brain concentration and duration.
PLoS ONE, 2020 Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang +7 more
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Cardiac Safety of Intranasal Chlorpheniramine: An Exposure-Based Risk Assessment [PDF]
PharmaceuticalsBackground: H1-antihistamines are widely used for allergic and upper respiratory conditions; however, several agents included in this class have been associated with cardiac electrophysiological adverse effects, including QT interval prolongation and ...
César Alas-Pineda +3 more
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Журнал микробиологии, эпидемиологии и иммунобиологии, 2019 The aim of present research is studying of protective potency of candidate recombinant live pertussis vaccine (RLPV) for intranasal administration.Materials and methods.
L. N. Sinyashina +4 more
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Nose-to-brain delivery of donepezil within a small dose improves bioavailability and efficacy for Alzheimer’s disease treatment [PDF]
Asian Journal of Pharmaceutical SciencesOral administration of donepezil (Don) is the first-line medication for Alzheimer’s disease (AD); however, the dysphagia of elderly patients and severe gastrointestinal side effects substantially restrict administration compliance.
Gang Wang +5 more
doaj +2 more sources
Utility of a Novel Micro-Spraying Device for Intranasal Administration of Drug Solutions to Mice
Pharmaceutics, 2023 Intranasal administration has attracted attention as a means of delivering drugs because it bypasses the blood–brain barrier. However, conventional intranasal administration of drug solutions to mice using the micropipette method (MP method) is ...
Naoto Suzuki +6 more
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