Results 11 to 20 of about 1,950,111 (204)

Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications [PDF]

Pharmaceutics, 2023
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Jesus Vicente de Julián-Ortiz, Amparo Nácher, Raquel Taléns-Visconti   +2 more
exaly   +4 more sources

Intranasal creatine administration increases brain creatine level and improves Barnes maze performance in rats

Brain Research Bulletin, 2023
While skeletal muscle creatine levels can be enhanced by exogenous creatine supplementation, the elevation of brain creatine levels with oral creatine administration remains a challenge due to a lack of effective transportation of creatine through the ...
Kaiqing Chen, Xiaoping Hu
doaj   +2 more sources

Bioavailability of butorphanol after intranasal administration to horses. [PDF]

Bulgarian Journal of Veterinary Medicine, 2020
The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or ...
V. Ferreira, M. I. Velloso , M. F. Landoni   +2 more
doaj   +2 more sources

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]

, 2003
The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Dufès, Christine, Couet, William, Olivier, Jean-Christophe, Gaillard, Frédéric, Gaillard, Afsaneh, Muller, Jean-Marc   +5 more
core   +3 more sources

Utility of a Novel Micro-Spraying Device for Intranasal Administration of Drug Solutions to Mice

Pharmaceutics, 2023
Intranasal administration has attracted attention as a means of delivering drugs because it bypasses the blood–brain barrier. However, conventional intranasal administration of drug solutions to mice using the micropipette method (MP method) is ...
Naoto Suzuki, Hiroaki Tanigawa, Taiki Nagatomo, Hiroko Miyagishi, Takanori Kanazawa, Toyofumi Suzuki, Yasuhiro Kosuge   +6 more
doaj   +1 more source

Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers

Pain Research and Management, 2021
Background. For more than 60 years, the synthetic opioid fentanyl has been widely used in anaesthesia and analgesia. While the intravenous formulation is primarily used for general anaesthesia and intensive care settings, the drug’s high lipophilic ...
S. Nardi-Hiebl, J. W. Ndieyira, Y. Al Enzi, W. Al Akkad, T. Koch, G. Geldner, C. Reyher, L. H. J. Eberhart   +7 more
doaj   +1 more source

Intranasal administration of collagenase develops cerebral microbleeds and vascular dementia in mice: In vivo pilot study

Brain Hemorrhages, 2023
Objective: To establish a new animal model of lobar cerebral microbleeds (CMBs), we examined whether intranasal administration of collagenase induced CMBs in young mice which did not have hypertensive pathologic features. Methods: We used thirty-two male
Kenyu Hayashi, Prativa Sherchan, John H. Zhang, Yu Hasegawa   +3 more
doaj   +1 more source

Intranasal Administration of Drugs [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2008
To investigate how nasally applied substances distribute in the nose depending on the form of application.Observer-blinded study.University hospital research unit.Fifteen healthy volunteers aged 22 to 32 years.Forms of application included (1) nasal drops applied with a pipette, (2) nasal spray, and (3) a system producing squirts.
Mandy, Scheibe, Christopher, Bethge, Martin, Witt, Thomas, Hummel   +3 more
openaire   +2 more sources

Intranasal Vaccination With Recombinant Antigen-FLIPr Fusion Protein Alone Induces Long-Lasting Systemic Antibody Responses and Broad T Cell Responses

Frontiers in Immunology, 2021
A simple formulation is urgently needed for mucosal vaccine development. We employed formyl peptide receptor-like 1 inhibitory protein (FLIPr), an FcγR antagonist secreted by Staphylococcus aureus, as a vector to target ovalbumin (OVA) to dendritic cells
Ming-Shu Hsieh, Chia-Wei Hsu, Ling-Ling Tu, Kit Man Chai, Li-Lu Yu, Chiao-Chieh Wu, Mei-Yu Chen, Chen-Yi Chiang, Shih-Jen Liu, Shih-Jen Liu, Shih-Jen Liu, Ching-Len Liao, Hsin-Wei Chen, Hsin-Wei Chen, Hsin-Wei Chen   +14 more
doaj   +1 more source

Intranasal Administration of N-acetyl-L-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

Pharmaceutics, 2022
Intranasal administration is a promising route for direct drug delivery to the brain; its combination with nanocarriers enhances delivery. We have previously shown that intranasal administration combined with PEG-PCL-Tat (a nanocarrier) efficiently ...
Takumi Kurano, Takanori Kanazawa, Shingo Iioka, Hiromu Kondo, Yasuhiro Kosuge, Toyofumi Suzuki   +5 more
doaj   +1 more source